Pleckstrin-2 promotes the progression of colorectal cancer via YTHDF2-mediated TYMS mRNA stability

High expression of nucleotide synthetic enzyme thymidylate synthase (TYMS) is responsible for the resistance to fluorouracil (FU) treatment and worse survival in colorectal cancer (CRC). Herein, we revealed that pleckstrin-2 (PLEK2) cooperated with YTHDF2 to enhance TYMS mRNA stability in CRC via an...

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Vydáno v:	Cellular and molecular life sciences : CMLS Ročník 82; číslo 1; s. 284 - 15
Hlavní autoři:	Zhou, Qian, Li, Yanxia, Li, Xiaomei, Zhang, Shujing, Wang, Ying, Li, Zhuoran, Wang, Xia, Li, Yuan, Li, Jingxin, Lu, Chunhua, Shen, Yuemao, Zhao, Baobing
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Cham Springer International Publishing 19.07.2025 Springer Nature B.V Springer
Témata:	5-Fluorouracil Animals Biochemistry Biomedical and Life Sciences Biomedicine Cancer Cell adhesion & migration Cell Biology Cell cycle Cell growth Cell Line, Tumor Cell migration Cell Movement - genetics Cell proliferation Cell Proliferation - genetics Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Disease Progression DNA biosynthesis Enzymes Experiments Gene expression Gene Expression Regulation, Neoplastic Humans Life Sciences M6A modification Medical prognosis Membrane Proteins - genetics Membrane Proteins - metabolism Metastasis Mice mRNA stability Nucleotides Original Original Article p53 Protein Pleckstrin Pleckstrin-2 Proteins RNA Stability - genetics RNA, Messenger - genetics RNA, Messenger - metabolism RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Senescence Signal Transduction Stability Therapeutic targets Thymidylate synthase Thymidylate Synthase - genetics Thymidylate Synthase - metabolism Tumor Suppressor Protein p53 - metabolism Tumorigenesis Tumors TYMS YTHDF2 A modification YTHDF2 TYMS M Pleckstrin-2 Colorectal cancer M6A modification
ISSN:	1420-9071, 1420-682X, 1420-9071
On-line přístup:	Získat plný text
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