Pleckstrin-2 promotes the progression of colorectal cancer via YTHDF2-mediated TYMS mRNA stability

High expression of nucleotide synthetic enzyme thymidylate synthase (TYMS) is responsible for the resistance to fluorouracil (FU) treatment and worse survival in colorectal cancer (CRC). Herein, we revealed that pleckstrin-2 (PLEK2) cooperated with YTHDF2 to enhance TYMS mRNA stability in CRC via an...

Full description

Saved in:

Bibliographic Details
Published in:	Cellular and molecular life sciences : CMLS Vol. 82; no. 1; pp. 284 - 15
Main Authors:	Zhou, Qian, Li, Yanxia, Li, Xiaomei, Zhang, Shujing, Wang, Ying, Li, Zhuoran, Wang, Xia, Li, Yuan, Li, Jingxin, Lu, Chunhua, Shen, Yuemao, Zhao, Baobing
Format:	Journal Article
Language:	English
Published:	Cham Springer International Publishing 19.07.2025 Springer Nature B.V Springer
Subjects:	5-Fluorouracil Animals Biochemistry Biomedical and Life Sciences Biomedicine Cancer Cell adhesion & migration Cell Biology Cell cycle Cell growth Cell Line, Tumor Cell migration Cell Movement - genetics Cell proliferation Cell Proliferation - genetics Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Disease Progression DNA biosynthesis Enzymes Experiments Gene expression Gene Expression Regulation, Neoplastic Humans Life Sciences M6A modification Medical prognosis Membrane Proteins - genetics Membrane Proteins - metabolism Metastasis Mice mRNA stability Nucleotides Original Original Article p53 Protein Pleckstrin Pleckstrin-2 Proteins RNA Stability - genetics RNA, Messenger - genetics RNA, Messenger - metabolism RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Senescence Signal Transduction Stability Therapeutic targets Thymidylate synthase Thymidylate Synthase - genetics Thymidylate Synthase - metabolism Tumor Suppressor Protein p53 - metabolism Tumorigenesis Tumors TYMS YTHDF2 A modification YTHDF2 TYMS M Pleckstrin-2 Colorectal cancer M6A modification
ISSN:	1420-9071, 1420-682X, 1420-9071
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!