The Gut Microbiome Contributes to a Substantial Proportion of the Variation in Blood Lipids

Evidence suggests that the gut microbiome is involved in the development of cardiovascular disease, with the host-microbe interaction regulating immune and metabolic pathways. However, there was no firm evidence for associations between microbiota and metabolic risk factors for cardiovascular diseas...

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Veröffentlicht in:Circulation research Jg. 117; H. 9; S. 817
Hauptverfasser: Fu, Jingyuan, Bonder, Marc Jan, Cenit, María Carmen, Tigchelaar, Ettje F, Maatman, Astrid, Dekens, Jackie A M, Brandsma, Eelke, Marczynska, Joanna, Imhann, Floris, Weersma, Rinse K, Franke, Lude, Poon, Tiffany W, Xavier, Ramnik J, Gevers, Dirk, Hofker, Marten H, Wijmenga, Cisca, Zhernakova, Alexandra
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 09.10.2015
Schlagworte:
Adolescent
Adult
Aged
Aged, 80 and over
Algorithms
Bacteria - classification
Bacteria - genetics
Body Mass Index
Cardiovascular Diseases - blood
Cardiovascular Diseases - genetics
Cardiovascular Diseases - microbiology
Cholesterol - blood
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Cohort Studies
Female
Gastrointestinal Microbiome - genetics
Gastrointestinal Microbiome - physiology
Host-Pathogen Interactions
Humans
Lipids - blood
Male
Middle Aged
Polymorphism, Single Nucleotide
Risk Assessment - methods
Risk Assessment - statistics & numerical data
Risk Factors
RNA, Ribosomal, 16S - genetics
Triglycerides - blood
Young Adult
HDL
lipids
metabolism
cardiovascular diseases
body mass index
lipoproteins
ISSN:1524-4571, 1524-4571
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Zusammenfassung:Evidence suggests that the gut microbiome is involved in the development of cardiovascular disease, with the host-microbe interaction regulating immune and metabolic pathways. However, there was no firm evidence for associations between microbiota and metabolic risk factors for cardiovascular disease from large-scale studies in humans. In particular, there was no strong evidence for association between cardiovascular disease and aberrant blood lipid levels. To identify intestinal bacteria taxa, whose proportions correlate with body mass index and lipid levels, and to determine whether lipid variance can be explained by microbiota relative to age, sex, and host genetics. We studied 893 subjects from the Life-Lines-DEEP population cohort. After correcting for age and sex, we identified 34 bacterial taxa associated with body mass index and blood lipids; most are novel associations. Cross-validation analysis revealed that microbiota explain 4.5% of the variance in body mass index, 6% in triglycerides, and 4% in high-density lipoproteins, independent of age, sex, and genetic risk factors. A novel risk model, including the gut microbiome explained ≤ 25.9% of high-density lipoprotein variance, significantly outperforming the risk model without microbiome. Strikingly, the microbiome had little effect on low-density lipoproteins or total cholesterol. Our studies suggest that the gut microbiome may play an important role in the variation in body mass index and blood lipid levels, independent of age, sex, and host genetics. Our findings support the potential of therapies altering the gut microbiome to control body mass, triglycerides, and high-density lipoproteins.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1524-4571
1524-4571
DOI:10.1161/CIRCRESAHA.115.306807