A novel bioreactor and culture method drives high yields of platelets from stem cells

BACKGROUND Platelet (PLT) transfusion is the primary treatment for thrombocytopenia. PLTs are obtained exclusively from volunteer donors, and the PLT product has only a 5‐day shelf life, which can limit supply and result in PLT shortages. PLTs derived from stem cells could help to fill this clinical...

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Bibliographic Details

Published in:	Transfusion (Philadelphia, Pa.) Vol. 56; no. 1; pp. 170 - 178
Main Authors:	Avanzi, Mauro P., Oluwadara, Oluwasijibomi E., Cushing, Melissa M., Mitchell, Maxwell L., Fischer, Stephen, Mitchell, W. Beau
Format:	Journal Article
Language:	English
Published:	United States Blackwell Publishing Ltd 01.01.2016 Wiley Subscription Services, Inc
Subjects:	Bioreactors Blood Platelets - physiology Cell Culture Techniques - instrumentation Cell Culture Techniques - methods Cell Differentiation Cells, Cultured Culture Media, Serum-Free Fetal Blood - cytology Flow Cytometry Hematopoietic Stem Cells - physiology Humans Megakaryocytes - physiology Platelet Transfusion Stem cells
ISSN:	0041-1132, 1537-2995, 1537-2995
Online Access:	Get full text
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