Effect of HMGCR Variant Alleles on Low-Density Lipoprotein Cholesterol-Lowering Response to Atorvastatin in Healthy Korean Subjects

The investigators quantified the relationship between the genetic polymorphism of HMGCR (3-hydroxy-3-methylglutaryl coenzyme A reductase) and the low-density lipoprotein cholesterol (LDL-C)–lowering effects of atorvastatin in a prospective clinical study. Twenty-four healthy participants were groupe...

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Bibliographic Details
Published in:	Journal of clinical pharmacology Vol. 52; no. 3; pp. 339 - 346
Main Authors:	Chung, Jae Yong, Cho, Sung Kweon, Oh, Eun Sil, Lee, Dong Hwan, Lim, Lay Ahyoung, Jang, Seong Bok, Lee, Yoon Jung, Park, Kyungsoo, Park, Min Soo
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01.03.2012 SAGE Publications Wiley Subscription Services, Inc
Subjects:	Adult Asian Continental Ancestry Group - genetics Atorvastatin Atorvastatin Calcium Cholesterol Cholesterol, LDL - blood cholesterol-lowering drugs Creatinine Female Gene polymorphism Genotype Heptanoic Acids - pharmacology HMG-CoA reductase Humans Hydroxymethylglutaryl CoA Reductases - genetics Hydroxymethylglutaryl CoA Reductases - metabolism Hydroxymethylglutaryl-CoA reductase Hypolipidemic Agents - pharmacology Lipids Lipoproteins Low density lipoprotein Male pharmacogenetics Pharmacokinetics Polymorphism, Genetic Pyrroles - pharmacology Serum levels Triglycerides Young Adult lipids HMG-CoA reductase cholesterol-lowering drugs atorvastatin pharmacogenetics
ISSN:	0091-2700, 1552-4604, 1552-4604
Online Access:	Get full text
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