Distinct aging profiles of CD8+ T cells in blood versus gastrointestinal mucosal compartments

A hallmark of human immunosenescence is the accumulation of late-differentiated memory CD8+ T cells with features of replicative senescence, such as inability to proliferate, absence of CD28 expression, shortened telomeres, loss of telomerase activity, enhanced activation, and increased secretion of...

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Bibliographic Details
Published in:	PloS one Vol. 12; no. 8; p. e0182498
Main Authors:	Dock, Jeffrey, Ramirez, Christina M., Hultin, Lance, Hausner, Mary Ann, Hultin, Patricia, Elliott, Julie, Yang, Otto O., Anton, Peter A., Jamieson, Beth D., Effros, Rita B.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 23.08.2017 Public Library of Science (PLoS)
Subjects:	Acquired immune deficiency syndrome Adaptive systems Age Aging AIDS Antigens Bioaccumulation Biology and life sciences Blood Blood cells CD25 antigen CD28 antigen CD3 antigen CD38 antigen CD45RA antigen CD57 antigen CD8 antigen CD8-Positive T-Lymphocytes - cytology Cell activation Cell Proliferation Cellular Senescence Chronic illnesses Colon Compartments Computer memory Cytokines Cytomegalovirus Differentiation Digestive system Digestive tract Flow Cytometry Gastrointestinal tract Geriatrics Gut-associated lymphoid tissues Health care Health risks Hematology Histocompatibility antigen HLA HIV Homeostasis Human immunodeficiency virus Humans Immune status Immune system Immunological memory In vitro methods and tests Infections Infectious diseases Inflammation Intestinal Mucosa - cytology Laboratories Lymphocytes Lymphocytes T Medicine Medicine and health sciences Morbidity Mortality Mortality risk Mucosa Older people Oncology Public health Senescence Studies Telomerase Tissues Los Angeles California United States > US
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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