Apelin Increases Cardiac Contractility via Protein Kinase Cε- and Extracellular Signal-Regulated Kinase-Dependent Mechanisms

Apelin, the endogenous ligand for the G protein-coupled apelin receptor, is an important regulator of the cardiovascular homoeostasis. We previously demonstrated that apelin is one of the most potent endogenous stimulators of cardiac contractility; however, its underlying signaling mechanisms remain...

Full description

Saved in:

Bibliographic Details
Published in:	PloS one Vol. 9; no. 4; p. e93473
Main Authors:	Perjés, Ábel, Skoumal, Réka, Tenhunen, Olli, Kónyi, Attila, Simon, Mihály, Horváth, Iván G., Kerkelä, Risto, Ruskoaho, Heikki, Szokodi, István
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 02.04.2014 Public Library of Science (PLoS)
Subjects:	Activation Animals Apelin Biology and life sciences Calcium Cardiomyocytes Cytosol Extracellular signal-regulated kinase Heart Heart attacks Heart diseases Heart failure Heart Ventricles - metabolism Heart Ventricles - physiopathology Inhibition Intercellular Signaling Peptides and Proteins - metabolism Kinases Light Male MAP Kinase Signaling System - physiology Medical schools Medicine and Health Sciences Muscle contraction Muscle Contraction - physiology Myocardial Contraction - physiology Myosin Myosin-light-chain kinase Myosin-Light-Chain Kinase - metabolism Peptides Pharmacology Phosphorylation Phosphorylation - physiology Protein kinase C Protein Kinase C-alpha - metabolism Protein Kinase C-epsilon - metabolism Proteins Rats Rats, Sprague-Dawley Research and Analysis Methods Rodents Signal Transduction - physiology Signaling Stimulators Toxicology Translocation Ventricle Hungary Finland
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!