Cell-Free (RNA) and Cell-Associated (DNA) HIV-1 and Postnatal Transmission through Breastfeeding

Transmission through breastfeeding remains important for mother-to-child transmission (MTCT) in resource-limited settings. We quantify the relationship between cell-free (RNA) and cell-associated (DNA) shedding of HIV-1 virus in breastmilk and the risk of postnatal HIV-1 transmission in the first 6...

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Bibliographic Details
Published in:	PloS one Vol. 7; no. 12; p. e51493
Main Authors:	Ndirangu, James, Viljoen, Johannes, Bland, Ruth M., Danaviah, Siva, Thorne, Claire, Van de Perre, Philippe, Newell, Marie-Louise
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 28.12.2012 Public Library of Science (PLoS)
Subjects:	Acquired immune deficiency syndrome Adult AIDS Antiretroviral agents Antiretroviral drugs Antiretroviral therapy Biology Breast feeding Breast Feeding - adverse effects Breast milk Breastfeeding & lactation Case-Control Studies CD4 antigen Deoxyribonucleic acid Disease transmission DNA DNA, Viral - analysis Drugs Female Health risks HIV HIV Infections - transmission HIV Infections - virology HIV-1 - genetics HIV-1 - isolation & purification HIV-1 - physiology Human immunodeficiency virus Humans Infant Infant, Newborn Infectious Disease Transmission, Vertical - statistics & numerical data Lactation Medicine Milk, Human - virology Postpartum Postpartum Period Regression analysis Ribonucleic acid Risk Factors RNA RNA, Viral - analysis Shedding Time Factors Viruses Young Adult France Africa
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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