Inflammation and Renal Function after a Four-Year Follow-Up in Subjects with Unimpaired Glomerular Filtration Rate: Results from the Observational, Population-Based CARLA Cohort

There is evidence that chronic inflammation is associated with the progression/development of chronic renal failure; however, relations in subjects with preserved renal function remain insufficiently understood. To examine the association of inflammation with the development of renal failure in a co...

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Vydáno v:	PloS one Ročník 9; číslo 9; s. e108427
Hlavní autoři:	Medenwald, Daniel, Girndt, Matthias, Loppnow, Harald, Kluttig, Alexander, Nuding, Sebastian, Tiller, Daniel, Thiery, Joachim J., Greiser, Karin H., Haerting, Johannes, Werdan, Karl
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Public Library of Science 26.09.2014 Public Library of Science (PLoS)
Témata:	Aged Aged, 80 and over Bias C-reactive protein C-Reactive Protein - metabolism Cardiovascular disease Creatinine Creatinine - blood Cross-Sectional Studies Diabetes Epidemiology Epidermal growth factor receptors Failure Family medical history Female Follow-Up Studies Gender differences Geriatrics Glomerular filtration rate Glomerular Filtration Rate - physiology Heart Humans Hypertension Inflammation Inflammation - blood Inflammation - physiopathology Informatics Interleukin 6 Internal medicine Kidney - physiopathology Kidney diseases Laboratories Longitudinal Studies Male Medical research Medicine Medicine and Health Sciences Middle Aged Missing data Older people Population Regression analysis Regression models Renal failure Renal function Renal Insufficiency, Chronic - blood Renal Insufficiency, Chronic - diagnosis Renal Insufficiency, Chronic - physiopathology Rodents Studies TNF inhibitors Tumor necrosis factor Tumor necrosis factor-TNF Tumors Values Womens health Germany
ISSN:	1932-6203, 1932-6203
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Shrnutí:	There is evidence that chronic inflammation is associated with the progression/development of chronic renal failure; however, relations in subjects with preserved renal function remain insufficiently understood. To examine the association of inflammation with the development of renal failure in a cohort of the elderly general population. After excluding subjects with reduced estimated glomerular filtration rate (eGFR<60 mL/min/1.73 m2) and missing data, the cohort incorporated 785 men and 659 women (aged 45-83 years). Follow-up was performed four years after baseline. Covariate adjusted linear and logistic regression models were used to assess the association of plasma/serum concentrations of soluble tumour necrosis factor receptor 1 (sTNF-R1), C-reactive protein (CRP), and interleukin 6 (IL-6) with change in eGFR/creatinine. The areas under the curve (AUCs) from receiver operating characteristics (ROCs) were estimated. In adjusted models sTNF-R1 was distinctively associated with a decline in eGFR in men (0.6 mL/min/1.73 m2 per 100 pg/mL sTNF-R1; 95% CI: 0.4-0.8), but not in women. A similar association could not be found for CRP or IL-6. Estimates of sTNF-R1 in the cross-sectional analyses were similar between sexes, while CRP and IL-6 were not relevantly associated with eGFR/creatinine. In the elderly male general population with preserved renal function sTNF-R1 predicts the development of renal failure.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Undefined-3 Conceived and designed the experiments: DT AK JH KW KHG JT SN. Performed the experiments: HL JT. Analyzed the data: DM MG. Contributed reagents/materials/analysis tools: DM MG AK DT JH KW HL. Contributed to the writing of the manuscript: DM MG AK DT JH KW. Organized the study: AK DT JH KW SN KHG JT. Competing Interests: The authors have declared that no competing interests exist.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0108427