Inflammation and Renal Function after a Four-Year Follow-Up in Subjects with Unimpaired Glomerular Filtration Rate: Results from the Observational, Population-Based CARLA Cohort

There is evidence that chronic inflammation is associated with the progression/development of chronic renal failure; however, relations in subjects with preserved renal function remain insufficiently understood. To examine the association of inflammation with the development of renal failure in a co...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	PloS one Ročník 9; číslo 9; s. e108427
Hlavní autori:	Medenwald, Daniel, Girndt, Matthias, Loppnow, Harald, Kluttig, Alexander, Nuding, Sebastian, Tiller, Daniel, Thiery, Joachim J., Greiser, Karin H., Haerting, Johannes, Werdan, Karl
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Public Library of Science 26.09.2014 Public Library of Science (PLoS)
Predmet:	Aged Aged, 80 and over Bias C-reactive protein C-Reactive Protein - metabolism Cardiovascular disease Creatinine Creatinine - blood Cross-Sectional Studies Diabetes Epidemiology Epidermal growth factor receptors Failure Family medical history Female Follow-Up Studies Gender differences Geriatrics Glomerular filtration rate Glomerular Filtration Rate - physiology Heart Humans Hypertension Inflammation Inflammation - blood Inflammation - physiopathology Informatics Interleukin 6 Internal medicine Kidney - physiopathology Kidney diseases Laboratories Longitudinal Studies Male Medical research Medicine Medicine and Health Sciences Middle Aged Missing data Older people Population Regression analysis Regression models Renal failure Renal function Renal Insufficiency, Chronic - blood Renal Insufficiency, Chronic - diagnosis Renal Insufficiency, Chronic - physiopathology Rodents Studies TNF inhibitors Tumor necrosis factor Tumor necrosis factor-TNF Tumors Values Womens health Germany
ISSN:	1932-6203, 1932-6203
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Abstract	There is evidence that chronic inflammation is associated with the progression/development of chronic renal failure; however, relations in subjects with preserved renal function remain insufficiently understood. To examine the association of inflammation with the development of renal failure in a cohort of the elderly general population. After excluding subjects with reduced estimated glomerular filtration rate (eGFR<60 mL/min/1.73 m2) and missing data, the cohort incorporated 785 men and 659 women (aged 45-83 years). Follow-up was performed four years after baseline. Covariate adjusted linear and logistic regression models were used to assess the association of plasma/serum concentrations of soluble tumour necrosis factor receptor 1 (sTNF-R1), C-reactive protein (CRP), and interleukin 6 (IL-6) with change in eGFR/creatinine. The areas under the curve (AUCs) from receiver operating characteristics (ROCs) were estimated. In adjusted models sTNF-R1 was distinctively associated with a decline in eGFR in men (0.6 mL/min/1.73 m2 per 100 pg/mL sTNF-R1; 95% CI: 0.4-0.8), but not in women. A similar association could not be found for CRP or IL-6. Estimates of sTNF-R1 in the cross-sectional analyses were similar between sexes, while CRP and IL-6 were not relevantly associated with eGFR/creatinine. In the elderly male general population with preserved renal function sTNF-R1 predicts the development of renal failure.
AbstractList	There is evidence that chronic inflammation is associated with the progression/development of chronic renal failure; however, relations in subjects with preserved renal function remain insufficiently understood. To examine the association of inflammation with the development of renal failure in a cohort of the elderly general population. After excluding subjects with reduced estimated glomerular filtration rate (eGFR<60 mL/min/1.73 m2) and missing data, the cohort incorporated 785 men and 659 women (aged 45-83 years). Follow-up was performed four years after baseline. Covariate adjusted linear and logistic regression models were used to assess the association of plasma/serum concentrations of soluble tumour necrosis factor receptor 1 (sTNF-R1), C-reactive protein (CRP), and interleukin 6 (IL-6) with change in eGFR/creatinine. The areas under the curve (AUCs) from receiver operating characteristics (ROCs) were estimated. In adjusted models sTNF-R1 was distinctively associated with a decline in eGFR in men (0.6 mL/min/1.73 m2 per 100 pg/mL sTNF-R1; 95% CI: 0.4-0.8), but not in women. A similar association could not be found for CRP or IL-6. Estimates of sTNF-R1 in the cross-sectional analyses were similar between sexes, while CRP and IL-6 were not relevantly associated with eGFR/creatinine. In the elderly male general population with preserved renal function sTNF-R1 predicts the development of renal failure. Background There is evidence that chronic inflammation is associated with the progression/development of chronic renal failure; however, relations in subjects with preserved renal function remain insufficiently understood. Objective To examine the association of inflammation with the development of renal failure in a cohort of the elderly general population. Methods After excluding subjects with reduced estimated glomerular filtration rate (eGFR<60 mL/min/1.73 m2) and missing data, the cohort incorporated 785 men and 659 women (aged 45–83 years). Follow-up was performed four years after baseline. Covariate adjusted linear and logistic regression models were used to assess the association of plasma/serum concentrations of soluble tumour necrosis factor receptor 1 (sTNF-R1), C-reactive protein (CRP), and interleukin 6 (IL-6) with change in eGFR/creatinine. The areas under the curve (AUCs) from receiver operating characteristics (ROCs) were estimated. Results In adjusted models sTNF-R1 was distinctively associated with a decline in eGFR in men (0.6 mL/min/1.73 m2 per 100 pg/mL sTNF-R1; 95% CI: 0.4–0.8), but not in women. A similar association could not be found for CRP or IL-6. Estimates of sTNF-R1 in the cross-sectional analyses were similar between sexes, while CRP and IL-6 were not relevantly associated with eGFR/creatinine. Conclusion In the elderly male general population with preserved renal function sTNF-R1 predicts the development of renal failure. Background There is evidence that chronic inflammation is associated with the progression/development of chronic renal failure; however, relations in subjects with preserved renal function remain insufficiently understood. Objective To examine the association of inflammation with the development of renal failure in a cohort of the elderly general population. Methods After excluding subjects with reduced estimated glomerular filtration rate (eGFR<60 mL/min/1.73 m 2 ) and missing data, the cohort incorporated 785 men and 659 women (aged 45–83 years). Follow-up was performed four years after baseline. Covariate adjusted linear and logistic regression models were used to assess the association of plasma/serum concentrations of soluble tumour necrosis factor receptor 1 (sTNF-R1), C-reactive protein (CRP), and interleukin 6 (IL-6) with change in eGFR/creatinine. The areas under the curve (AUCs) from receiver operating characteristics (ROCs) were estimated. Results In adjusted models sTNF-R1 was distinctively associated with a decline in eGFR in men (0.6 mL/min/1.73 m 2 per 100 pg/mL sTNF-R1; 95% CI: 0.4–0.8), but not in women. A similar association could not be found for CRP or IL-6. Estimates of sTNF-R1 in the cross-sectional analyses were similar between sexes, while CRP and IL-6 were not relevantly associated with eGFR/creatinine. Conclusion In the elderly male general population with preserved renal function sTNF-R1 predicts the development of renal failure. There is evidence that chronic inflammation is associated with the progression/development of chronic renal failure; however, relations in subjects with preserved renal function remain insufficiently understood.To examine the association of inflammation with the development of renal failure in a cohort of the elderly general population.After excluding subjects with reduced estimated glomerular filtration rate (eGFR<60 mL/min/1.73 m2) and missing data, the cohort incorporated 785 men and 659 women (aged 45-83 years). Follow-up was performed four years after baseline. Covariate adjusted linear and logistic regression models were used to assess the association of plasma/serum concentrations of soluble tumour necrosis factor receptor 1 (sTNF-R1), C-reactive protein (CRP), and interleukin 6 (IL-6) with change in eGFR/creatinine. The areas under the curve (AUCs) from receiver operating characteristics (ROCs) were estimated.In adjusted models sTNF-R1 was distinctively associated with a decline in eGFR in men (0.6 mL/min/1.73 m2 per 100 pg/mL sTNF-R1; 95% CI: 0.4-0.8), but not in women. A similar association could not be found for CRP or IL-6. Estimates of sTNF-R1 in the cross-sectional analyses were similar between sexes, while CRP and IL-6 were not relevantly associated with eGFR/creatinine.In the elderly male general population with preserved renal function sTNF-R1 predicts the development of renal failure. There is evidence that chronic inflammation is associated with the progression/development of chronic renal failure; however, relations in subjects with preserved renal function remain insufficiently understood.BACKGROUNDThere is evidence that chronic inflammation is associated with the progression/development of chronic renal failure; however, relations in subjects with preserved renal function remain insufficiently understood.To examine the association of inflammation with the development of renal failure in a cohort of the elderly general population.OBJECTIVETo examine the association of inflammation with the development of renal failure in a cohort of the elderly general population.After excluding subjects with reduced estimated glomerular filtration rate (eGFR<60 mL/min/1.73 m2) and missing data, the cohort incorporated 785 men and 659 women (aged 45-83 years). Follow-up was performed four years after baseline. Covariate adjusted linear and logistic regression models were used to assess the association of plasma/serum concentrations of soluble tumour necrosis factor receptor 1 (sTNF-R1), C-reactive protein (CRP), and interleukin 6 (IL-6) with change in eGFR/creatinine. The areas under the curve (AUCs) from receiver operating characteristics (ROCs) were estimated.METHODSAfter excluding subjects with reduced estimated glomerular filtration rate (eGFR<60 mL/min/1.73 m2) and missing data, the cohort incorporated 785 men and 659 women (aged 45-83 years). Follow-up was performed four years after baseline. Covariate adjusted linear and logistic regression models were used to assess the association of plasma/serum concentrations of soluble tumour necrosis factor receptor 1 (sTNF-R1), C-reactive protein (CRP), and interleukin 6 (IL-6) with change in eGFR/creatinine. The areas under the curve (AUCs) from receiver operating characteristics (ROCs) were estimated.In adjusted models sTNF-R1 was distinctively associated with a decline in eGFR in men (0.6 mL/min/1.73 m2 per 100 pg/mL sTNF-R1; 95% CI: 0.4-0.8), but not in women. A similar association could not be found for CRP or IL-6. Estimates of sTNF-R1 in the cross-sectional analyses were similar between sexes, while CRP and IL-6 were not relevantly associated with eGFR/creatinine.RESULTSIn adjusted models sTNF-R1 was distinctively associated with a decline in eGFR in men (0.6 mL/min/1.73 m2 per 100 pg/mL sTNF-R1; 95% CI: 0.4-0.8), but not in women. A similar association could not be found for CRP or IL-6. Estimates of sTNF-R1 in the cross-sectional analyses were similar between sexes, while CRP and IL-6 were not relevantly associated with eGFR/creatinine.In the elderly male general population with preserved renal function sTNF-R1 predicts the development of renal failure.CONCLUSIONIn the elderly male general population with preserved renal function sTNF-R1 predicts the development of renal failure.
Author	Medenwald, Daniel Greiser, Karin H. Thiery, Joachim J. Haerting, Johannes Kluttig, Alexander Werdan, Karl Tiller, Daniel Girndt, Matthias Nuding, Sebastian Loppnow, Harald
AuthorAffiliation	Shanghai Institute of Hypertension, China 5 German Cancer Research Centre, Division of Cancer Epidemiology, Heidelberg, Germany 2 Department of Internal Medicine II, Martin-Luther-University Halle-Wittenberg, Halle/Saale, Germany 4 Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Leipzig, Germany 3 Department of Internal Medicine III, Martin-Luther-University Halle-Wittenberg, Halle/Saale, Germany 1 Institute of Medical Epidemiology, Biostatistics and Informatics, Martin-Luther-University Halle-Wittenberg, Halle/Saale, Germany
AuthorAffiliation_xml	– name: 3 Department of Internal Medicine III, Martin-Luther-University Halle-Wittenberg, Halle/Saale, Germany – name: Shanghai Institute of Hypertension, China – name: 4 Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Leipzig, Germany – name: 1 Institute of Medical Epidemiology, Biostatistics and Informatics, Martin-Luther-University Halle-Wittenberg, Halle/Saale, Germany – name: 5 German Cancer Research Centre, Division of Cancer Epidemiology, Heidelberg, Germany – name: 2 Department of Internal Medicine II, Martin-Luther-University Halle-Wittenberg, Halle/Saale, Germany
Author_xml	– sequence: 1 givenname: Daniel surname: Medenwald fullname: Medenwald, Daniel – sequence: 2 givenname: Matthias surname: Girndt fullname: Girndt, Matthias – sequence: 3 givenname: Harald surname: Loppnow fullname: Loppnow, Harald – sequence: 4 givenname: Alexander surname: Kluttig fullname: Kluttig, Alexander – sequence: 5 givenname: Sebastian surname: Nuding fullname: Nuding, Sebastian – sequence: 6 givenname: Daniel surname: Tiller fullname: Tiller, Daniel – sequence: 7 givenname: Joachim J. surname: Thiery fullname: Thiery, Joachim J. – sequence: 8 givenname: Karin H. surname: Greiser fullname: Greiser, Karin H. – sequence: 9 givenname: Johannes surname: Haerting fullname: Haerting, Johannes – sequence: 10 givenname: Karl surname: Werdan fullname: Werdan, Karl
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/25259714$$D View this record in MEDLINE/PubMed
BookMark	eNp9Uk1v1DAQjVAR_YB_gMASFw5k8UfiZHtAWlZsWWmlooUeOFlOMul65djBdlrxs_iHOLvbqq0QJ4_H7715M57T5MhYA0nymuAJYQX5uLWDM1JP-pieYILLjBbPkhMyZTTlFLOjB_Fxcur9FuOclZy_SI5pTvNpQbKT5M_StFp2nQzKGiRNg9YQVdFiMPU-1QZwSKJFLJf-BOlipLW9Ta96pAz6PlRbqINHtyps0JVRXS-VgwZdaNuBG_RIUDq4fYG1DHAeS_hBR07rbIfCBtBl5cHd7CBSf0DfbB-J4y39LH0Um8_Wqxma24114WXyvJXaw6vDeZZcLb78mH9NV5cXy_lsldY55SGtJWSMEckJQIEZoVUmi5LKMqvyssQltC2UhJKmncosl1RyVmPSxAnFObYkZ2fJ271ur60Xh2l7QXKe8ymmeBoRyz2isXIreqc66X4LK5XYJay7FtIFVWsQNANGODBOi2irJFVWMT5tSTTJSV0UUevTodpQddDUYOLI9CPRxy9GbcS1vREZKUqSj2beHwSc_TWAD6JTvgatpQE77HzzkpKsHDt79wT67-7ePHR0b-VudyIg2wNqZ7130N5DCBbjit7JinFFxWFFI-38Ca1WYffZsS-l_0_-C2i68W8
CitedBy_id	crossref_primary_10_3390_nu12061639 crossref_primary_10_1186_s12882_017_0608_4 crossref_primary_10_1371_journal_pone_0238421 crossref_primary_10_1016_j_amjmed_2022_12_001 crossref_primary_10_1097_HPC_0000000000000296 crossref_primary_10_2215_CJN_09280916 crossref_primary_10_2337_dc17_1919 crossref_primary_10_1002_ccd_28060 crossref_primary_10_1007_s10654_021_00824_7 crossref_primary_10_1111_jgs_15268 crossref_primary_10_1093_ndt_gfab294
Cites_doi	10.1161/01.HYP.0000198545.01860.90 10.1186/1471-2369-9-9 10.1155/2010/182958 10.1161/01.CIR.93.4.704 10.1111/j.1755-5922.2010.00218.x 10.1186/1471-2261-5-33 10.1007/s10654-009-9317-z 10.1038/ki.2011.283 10.1093/ndt/gfl469 10.5402/2012/501894 10.1007/s00125-009-1597-z 10.1016/j.cyto.2011.09.013 10.1007/s40618-014-0118-1 10.2215/CJN.03500412 10.1016/j.diabres.2011.01.008 10.1007/s10741-010-9180-8 10.1159/000335934 10.1159/000340033 10.1097/MNH.0b013e32834ba210 10.1016/S0022-5347(06)00490-3 10.1152/ajprenal.00557.2012
ContentType	Journal Article
Copyright	2014 Medenwald et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2014 Medenwald et al 2014 Medenwald et al
Copyright_xml	– notice: 2014 Medenwald et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2014 Medenwald et al 2014 Medenwald et al
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QG 7QL 7QO 7RV 7SN 7SS 7T5 7TG 7TM 7U9 7X2 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M7N M7P M7S NAPCQ P5Z P62 P64 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PTHSS PYCSY RC3 7X8 5PM DOA
DOI	10.1371/journal.pone.0108427
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts ProQuest Nursing and Allied Health Journals - PSU access expires 11/30/25. Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Meteorological & Geoastrophysical Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Materials Science & Engineering Collection (subscription) ProQuest Central (Alumni) ProQuest One Sustainability (subscription) ProQuest Central UK/Ireland Advanced Technologies & Computer Science Collection Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection ProQuest Central Technology Collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Materials Science Collection ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection Biological Sciences Agricultural Science Database Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database (subscription) Nursing & Allied Health Premium AAdvanced Technologies & Aerospace Database (subscription) ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database (subscripiton) Materials Science Collection ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China Engineering Collection Environmental Science Collection Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database Publicly Available Content Database ProQuest Central Student ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Materials Science Collection ProQuest Public Health ProQuest Nursing & Allied Health Source ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	MEDLINE Agricultural Science Database MEDLINE - Academic
Database_xml	– sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Sciences (General) Medicine
DocumentTitleAlternate	Inflammation and Change in Renal Function
EISSN	1932-6203
ExternalDocumentID	1565690209 oai_doaj_org_article_24e316e3627e4381b4b369f1ae461c77 PMC4178159 3444418121 25259714 10_1371_journal_pone_0108427
Genre	Research Support, Non-U.S. Gov't Journal Article Observational Study
GeographicLocations	Germany
GeographicLocations_xml	– name: Germany
GroupedDBID	--- 123 29O 2WC 53G 5VS 7RV 7X2 7X7 7XC 88E 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ AAUCC AAWOE AAYXX ABDBF ABIVO ABJCF ABUWG ACCTH ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV ADRAZ AEAQA AENEX AEUYN AFFHD AFKRA AFPKN AFRAH AHMBA ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ARAPS ATCPS BAWUL BBNVY BCNDV BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI BWKFM CCPQU CITATION CS3 D1I D1J D1K DIK DU5 E3Z EAP EAS EBD EMOBN ESX EX3 F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IEA IGS IHR IHW INH INR IOV IPY ISE ISR ITC K6- KB. KQ8 L6V LK5 LK8 M0K M1P M48 M7P M7R M7S M~E NAPCQ O5R O5S OK1 OVT P2P P62 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PTHSS PYCSY RNS RPM SV3 TR2 UKHRP WOQ WOW ~02 ~KM ALIPV BBORY CGR CUY CVF ECM EIF IPNFZ NPM PV9 RIG RZL 3V. 7QG 7QL 7QO 7SN 7SS 7T5 7TG 7TM 7U9 7XB 8FD 8FK AZQEC C1K DWQXO ESTFP FR3 GNUQQ H94 K9. KL. M7N P64 PKEHL PQEST PQUKI PRINS RC3 7X8 PUEGO 5PM AAPBV ABPTK
ID	FETCH-LOGICAL-c526t-cae4331a61ee70312b4a782a84b58808effe8121df9a45a2a63c01d538427f153
IEDL.DBID	P5Z
ISICitedReferencesCount	13
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000342685600072&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1932-6203
IngestDate	Sun Sep 03 00:14:26 EDT 2023 Fri Oct 03 12:37:08 EDT 2025 Tue Nov 04 01:59:56 EST 2025 Thu Oct 02 05:52:55 EDT 2025 Tue Oct 07 07:32:16 EDT 2025 Thu Apr 03 07:09:51 EDT 2025 Sat Nov 29 06:42:19 EST 2025 Tue Nov 18 21:29:09 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	9
Language	English
License	This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. Creative Commons Attribution License
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c526t-cae4331a61ee70312b4a782a84b58808effe8121df9a45a2a63c01d538427f153
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Undefined-3 Conceived and designed the experiments: DT AK JH KW KHG JT SN. Performed the experiments: HL JT. Analyzed the data: DM MG. Contributed reagents/materials/analysis tools: DM MG AK DT JH KW HL. Contributed to the writing of the manuscript: DM MG AK DT JH KW. Organized the study: AK DT JH KW SN KHG JT. Competing Interests: The authors have declared that no competing interests exist.
OpenAccessLink	https://www.proquest.com/docview/1565690209?pq-origsite=%requestingapplication%
PMID	25259714
PQID	1565690209
PQPubID	1436336
ParticipantIDs	plos_journals_1565690209 doaj_primary_oai_doaj_org_article_24e316e3627e4381b4b369f1ae461c77 pubmedcentral_primary_oai_pubmedcentral_nih_gov_4178159 proquest_miscellaneous_1566821485 proquest_journals_1565690209 pubmed_primary_25259714 crossref_primary_10_1371_journal_pone_0108427 crossref_citationtrail_10_1371_journal_pone_0108427
PublicationCentury	2000
PublicationDate	2014-09-26
PublicationDateYYYYMMDD	2014-09-26
PublicationDate_xml	– month: 09 year: 2014 text: 2014-09-26 day: 26
PublicationDecade	2010
PublicationPlace	United States
PublicationPlace_xml	– name: United States – name: San Francisco – name: San Francisco, USA
PublicationTitle	PloS one
PublicationTitleAlternate	PLoS One
PublicationYear	2014
Publisher	Public Library of Science Public Library of Science (PLoS)
Publisher_xml	– name: Public Library of Science – name: Public Library of Science (PLoS)
References	C Keller (ref4) 2008; (1) J Lin (ref8) 2010; (2) ref31 KH Greiser (ref12) 2005; 5 PD Metcalfe (ref30) 2008; (2) M Pruijm (ref3) 2012; (3) AV Cheuiche (ref16) 2013; (15) G Torre-Amione (ref18) 1996; (4) M Aomatsu (ref32) 2013; (1) I Miyazawa (ref7) 2011; (2) CR Keller (ref5) 2006; (3) PP Rickham (ref14) 1964; (5402) PD Metcalfe (ref28) 2006; (1) LA Cooker (ref24) 2007; (1) VD Ramseyer (ref20) 2013; (10) AS Levey (ref10) 2009; (9) KH Greiser (ref13) 2009; (3) J Gupta (ref1) 2012; (12) JF Navarro (ref2) 2006; (12) AA Elmarakby (ref22) 2012; (1) P Kleinbongard (ref19) 2011; (1) ref26 AA Elmarakby (ref25) 2006; (3) AS Levey (ref11) 1999; (6) FJ Therrien (ref23) 2012; (2) M Madero (ref15) 2011; (6) A Shankar (ref9) 2011; (11) N Carpena (ref6) 2012; 2012 TV Clendenen (ref21) 2011; (3) C Lorz (ref27) 2008; (5) MM Glymour (ref17) 2005; (3) JK Pai (ref29) 2004; (25) 19199053 - Eur J Epidemiol. 2009;24(3):123-42 23747959 - Clin Biochem. 2013 Oct;46(15):1423-9 18287563 - J Am Soc Nephrol. 2008 May;19(5):904-14 15602020 - N Engl J Med. 2004 Dec 16;351(25):2599-610 17183246 - Kidney Int. 2007 Feb;71(3):239-44 24140406 - Biochem Biophys Res Commun. 2013 Nov 8;441(1):220-5 23024164 - Clin J Am Soc Nephrol. 2012 Dec;7(12):1938-46 18073317 - Am J Physiol Endocrinol Metab. 2008 Feb;294(2):E435-43 21866089 - Kidney Int. 2011 Dec;80(11):1231-8 8640999 - Circulation. 1996 Feb 15;93(4):704-11 20718759 - Cardiovasc Ther. 2012 Feb;30(1):49-59 22398717 - Am J Nephrol. 2012;35(3):288-94 10075613 - Ann Intern Med. 1999 Mar 16;130(6):461-70 19414839 - Ann Intern Med. 2009 May 5;150(9):604-12 15987729 - Am J Epidemiol. 2005 Aug 1;162(3):267-78 20953353 - Mediators Inflamm. 2010;2010. pii: 182958. doi: 10.1155/2010/182958 21288590 - Diabetes Res Clin Pract. 2011 May;92(2):174-80 21941179 - Curr Opin Nephrol Hypertens. 2011 Nov;20(6):622-30 22015105 - Cytokine. 2011 Dec;56(3):769-78 24947177 - J Endocrinol Invest. 2014 Sep;37(9):861-9 16283930 - BMC Cardiovasc Disord. 2005;5:33 19921505 - Diabetologia. 2010 Feb;53(2):263-7 23515717 - Am J Physiol Renal Physiol. 2013 May 15;304(10):F1231-42 20571888 - Heart Fail Rev. 2011 Jan;16(1):49-69 17376761 - Am J Physiol Renal Physiol. 2007 Jul;293(1):F157-65 16753358 - J Urol. 2006 Jul;176(1):15-21 16415373 - Hypertension. 2006 Mar;47(3):557-62 18681974 - BMC Nephrol. 2008;9:9 23008783 - ISRN Cardiol. 2012;2012:501894 14150898 - Br Med J. 1964 Jul 18;2(5402):177 22813949 - Am J Nephrol. 2012;36(2):151-61 16935891 - Nephrol Dial Transplant. 2006 Dec;21(12):3428-34
References_xml	– volume: (3) start-page: 557 year: 2006 ident: ref25 article-title: Tumor necrosis factor alpha blockade increases renal Cyp2c23 expression and slows the progression of renal damage in salt-sensitive hypertension publication-title: Hypertension 47 doi: 10.1161/01.HYP.0000198545.01860.90 – volume: (1) start-page: 9 year: 2008 ident: ref4 article-title: Association of kidney function with inflammatory and procoagulant markers in a diverse cohort: a cross-sectional analysis from the Multi-Ethnic Study of Atherosclerosis (MESA) publication-title: BMC Nephrol 9 doi: 10.1186/1471-2369-9-9 – volume: (3) start-page: 239 year: 2006 ident: ref5 article-title: Kidney function and markers of inflammation in elderly persons without chronic kidney disease: The health, aging, and body composition study publication-title: Kidney Int 71 – volume: (1) start-page: 220 year: 2013 ident: ref32 article-title: Gender difference in tumor necrosis factor-α production in human neutrophils stimulated by lipopolysaccharide and interferon-γ. Biochem. Biophys. Res. Commun publication-title: 441 – volume: (3) start-page: 267 year: 2005 ident: ref17 article-title: When is baseline adjustment useful in analyses of change? An example with education and cognitive change. Am. J. Epidemiol publication-title: 162 – ident: ref26 doi: 10.1155/2010/182958 – volume: (5) start-page: 904 year: 2008 ident: ref27 article-title: The death ligand TRAIL in diabetic nephropathy. J. Am. Soc. Nephrol publication-title: 19 – volume: (4) start-page: 704 year: 1996 ident: ref18 article-title: Tumor Necrosis Factor- and Tumor Necrosis Factor Receptors in the Failing Human Heart publication-title: Circulation 93 doi: 10.1161/01.CIR.93.4.704 – volume: (1) start-page: 49 year: 2012 ident: ref22 article-title: Relationship between Oxidative Stress and Inflammatory Cytokines in Diabetic Nephropathy publication-title: Cardiovascular Therapeutics 30 doi: 10.1111/j.1755-5922.2010.00218.x – volume: 5 start-page: 33 year: 2005 ident: ref12 article-title: Cardiovascular disease, risk factors and heart rate variability in the elderly general population: design and objectives of the CARdiovascular disease, Living and Ageing in Halle (CARLA) Study publication-title: BMC Cardiovasc Disord doi: 10.1186/1471-2261-5-33 – volume: (15) start-page: 1423 year: 2013 ident: ref16 article-title: Comparison between IDMS-traceable Jaffe and enzymatic creatinine assays for estimation of glomerular filtration rate by the CKD-EPI equation in healthy and diabetic subjects. Clin. Biochem publication-title: 46 – volume: (3) start-page: 123 year: 2009 ident: ref13 article-title: Cardiovascular diseases, risk factors and short-term heart rate variability in an elderly general population: the CARLA study 2002–2006 publication-title: Eur J Epidemiol 24 doi: 10.1007/s10654-009-9317-z – volume: (11) start-page: 1231 year: 2011 ident: ref9 article-title: Markers of inflammation predict the long-term risk of developing chronic kidney disease: a population-based cohort study publication-title: Kidney Int 80 doi: 10.1038/ki.2011.283 – volume: (12) start-page: 3428 year: 2006 ident: ref2 article-title: Urinary tumour necrosis factor- excretion independently correlates with clinical markers of glomerular and tubulointerstitial injury in type 2 diabetic patients publication-title: Nephrology Dialysis Transplantation 21 doi: 10.1093/ndt/gfl469 – volume: (9) start-page: 604 year: 2009 ident: ref10 article-title: A new equation to estimate glomerular filtration rate. Ann. Intern. Med publication-title: 150 – volume: 2012 start-page: 501894 year: 2012 ident: ref6 article-title: MMP-2 and sTNF-R1 Variability in Patients with Essential Hypertension: 1-Year Follow-Up Study publication-title: ISRN Cardiol doi: 10.5402/2012/501894 – volume: (2) start-page: 263 year: 2010 ident: ref8 article-title: Lipid and inflammatory biomarkers and kidney function decline in type 2 diabetes publication-title: Diabetologia 53 doi: 10.1007/s00125-009-1597-z – volume: (3) start-page: 769 year: 2011 ident: ref21 article-title: Factors associated with inflammation markers, a cross-sectional analysis publication-title: Cytokine 56 doi: 10.1016/j.cyto.2011.09.013 – volume: (1) start-page: F157 year: 2007 ident: ref24 article-title: TNF-, but not IFN-, regulates CCN2 (CTGF), collagen type I, and proliferation in mesangial cells: possible roles in the progression of renal fibrosis publication-title: AJP: Renal Physiology 293 – ident: ref31 doi: 10.1007/s40618-014-0118-1 – volume: (12) start-page: 1938 year: 2012 ident: ref1 article-title: Association between Albuminuria, Kidney Function, and Inflammatory Biomarker Profile in CKD in CRIC publication-title: Clinical Journal of the American Society of Nephrology 7 doi: 10.2215/CJN.03500412 – volume: (5402) start-page: 177 year: 1964 ident: ref14 article-title: Human experimentation. Code of Ethics of the World Medical Association. Declaration of Helsinki publication-title: Br Med J 2 – volume: (2) start-page: 174 year: 2011 ident: ref7 article-title: Association between serum soluble TNFα receptors and renal dysfunction in type 2 diabetic patients without proteinuria publication-title: Diabetes Research and Clinical Practice 92 doi: 10.1016/j.diabres.2011.01.008 – volume: (1) start-page: 49 year: 2011 ident: ref19 article-title: TNFα in myocardial ischemia/reperfusion, remodeling and heart failure publication-title: Heart Fail Rev 16 doi: 10.1007/s10741-010-9180-8 – volume: (3) start-page: 288 year: 2012 ident: ref3 article-title: Not All Inflammatory Markers Are Linked to Kidney Function: Results from a Population-Based Study publication-title: Am J Nephrol 35 doi: 10.1159/000335934 – volume: (2) start-page: 151 year: 2012 ident: ref23 article-title: Neutralization of Tumor Necrosis Factor-Alpha Reduces Renal Fibrosis and Hypertension in Rats with Renal Failure publication-title: Am J Nephrol 36 doi: 10.1159/000340033 – volume: (6) start-page: 622 year: 2011 ident: ref15 article-title: Creatinine-based formulae for estimating glomerular filtration rate publication-title: Current Opinion in Nephrology and Hypertension 20 doi: 10.1097/MNH.0b013e32834ba210 – volume: (1) start-page: 15 year: 2006 ident: ref28 article-title: Sex Differences and the Role of Sex Steroids in Renal Injury publication-title: The Journal of Urology 176 doi: 10.1016/S0022-5347(06)00490-3 – volume: (10) start-page: F1231 year: 2013 ident: ref20 article-title: Tumor necrosis factor-α: regulation of renal function and blood pressure. Am publication-title: J. Physiol. Renal Physiol. 304 doi: 10.1152/ajprenal.00557.2012 – volume: (25) start-page: 2599 year: 2004 ident: ref29 article-title: Inflammatory Markers and the Risk of Coronary Heart Disease in Men and Women publication-title: N Engl J Med 351 – volume: (2) start-page: E435 year: 2008 ident: ref30 article-title: Testosterone exacerbates obstructive renal injury by stimulating TNF-alpha production and increasing proapoptotic and profibrotic signaling. Am. J. Physiol. Endocrinol. Metab publication-title: 294 – volume: (6) start-page: 461 year: 1999 ident: ref11 article-title: A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann. Intern. Med publication-title: 130 – reference: 15602020 - N Engl J Med. 2004 Dec 16;351(25):2599-610 – reference: 20718759 - Cardiovasc Ther. 2012 Feb;30(1):49-59 – reference: 21941179 - Curr Opin Nephrol Hypertens. 2011 Nov;20(6):622-30 – reference: 15987729 - Am J Epidemiol. 2005 Aug 1;162(3):267-78 – reference: 23008783 - ISRN Cardiol. 2012;2012:501894 – reference: 18287563 - J Am Soc Nephrol. 2008 May;19(5):904-14 – reference: 22813949 - Am J Nephrol. 2012;36(2):151-61 – reference: 24140406 - Biochem Biophys Res Commun. 2013 Nov 8;441(1):220-5 – reference: 16935891 - Nephrol Dial Transplant. 2006 Dec;21(12):3428-34 – reference: 20571888 - Heart Fail Rev. 2011 Jan;16(1):49-69 – reference: 21866089 - Kidney Int. 2011 Dec;80(11):1231-8 – reference: 24947177 - J Endocrinol Invest. 2014 Sep;37(9):861-9 – reference: 18073317 - Am J Physiol Endocrinol Metab. 2008 Feb;294(2):E435-43 – reference: 23747959 - Clin Biochem. 2013 Oct;46(15):1423-9 – reference: 16283930 - BMC Cardiovasc Disord. 2005;5:33 – reference: 14150898 - Br Med J. 1964 Jul 18;2(5402):177 – reference: 19921505 - Diabetologia. 2010 Feb;53(2):263-7 – reference: 22398717 - Am J Nephrol. 2012;35(3):288-94 – reference: 19414839 - Ann Intern Med. 2009 May 5;150(9):604-12 – reference: 18681974 - BMC Nephrol. 2008;9:9 – reference: 16753358 - J Urol. 2006 Jul;176(1):15-21 – reference: 23024164 - Clin J Am Soc Nephrol. 2012 Dec;7(12):1938-46 – reference: 23515717 - Am J Physiol Renal Physiol. 2013 May 15;304(10):F1231-42 – reference: 22015105 - Cytokine. 2011 Dec;56(3):769-78 – reference: 21288590 - Diabetes Res Clin Pract. 2011 May;92(2):174-80 – reference: 17183246 - Kidney Int. 2007 Feb;71(3):239-44 – reference: 20953353 - Mediators Inflamm. 2010;2010. pii: 182958. doi: 10.1155/2010/182958 – reference: 17376761 - Am J Physiol Renal Physiol. 2007 Jul;293(1):F157-65 – reference: 19199053 - Eur J Epidemiol. 2009;24(3):123-42 – reference: 8640999 - Circulation. 1996 Feb 15;93(4):704-11 – reference: 16415373 - Hypertension. 2006 Mar;47(3):557-62 – reference: 10075613 - Ann Intern Med. 1999 Mar 16;130(6):461-70
SSID	ssj0053866
Score	2.2107966
Snippet	There is evidence that chronic inflammation is associated with the progression/development of chronic renal failure; however, relations in subjects with... Background There is evidence that chronic inflammation is associated with the progression/development of chronic renal failure; however, relations in subjects... Background There is evidence that chronic inflammation is associated with the progression/development of chronic renal failure; however, relations in subjects...
SourceID	plos doaj pubmedcentral proquest pubmed crossref
SourceType	Open Website Open Access Repository Aggregation Database Index Database Enrichment Source
StartPage	e108427
SubjectTerms	Aged Aged, 80 and over Bias C-reactive protein C-Reactive Protein - metabolism Cardiovascular disease Creatinine Creatinine - blood Cross-Sectional Studies Diabetes Epidemiology Epidermal growth factor receptors Failure Family medical history Female Follow-Up Studies Gender differences Geriatrics Glomerular filtration rate Glomerular Filtration Rate - physiology Heart Humans Hypertension Inflammation Inflammation - blood Inflammation - physiopathology Informatics Interleukin 6 Internal medicine Kidney - physiopathology Kidney diseases Laboratories Longitudinal Studies Male Medical research Medicine Medicine and Health Sciences Middle Aged Missing data Older people Population Regression analysis Regression models Renal failure Renal function Renal Insufficiency, Chronic - blood Renal Insufficiency, Chronic - diagnosis Renal Insufficiency, Chronic - physiopathology Rodents Studies TNF inhibitors Tumor necrosis factor Tumor necrosis factor-TNF Tumors Values Womens health
SummonAdditionalLinks	– databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQxYELorwaKMhIHEAibZ34yW2pqECqKoRA6i1ybAdWCskq2VD1Z_EPmUm80S6q1Au3VWxvEs94_I0z8w0hr3kIwhjnQXkVTznPZVoGcFwlFyXTninrx6ol5-riQl9emi9bpb4wJmyiB54m7jjjIWcygJ1VAemoSl7m0lTMBi6ZU2MeOaCejTM12WBYxVLGRLlcseMol6NV24Qj8EA0xyoyWxvRyNeP_KZ129-ENf8Nmdzag84ekPsRPNLF9ND75E5oHpL9uDx7-iZySL99RP58biqQ9ZSXSG3jaRdwKG5j0yWsDU4treA_02tQd_hV1-1VOqzosqH9UOIBTU_xnJYODSZTgnH09Efd_godxq7SallHzl2KfBPv4Rb9UMMYTFmhACxpW85nvrZ-R1dzsbAUN09PTxdfzxcUa_R268fk-9nHb6ef0lidIXUik-vUgQTynFnJQkAS_KzkFuCG1bwUYBQ0xqMAemC-MpYLm1mZuxPmQTQw-RUY2idkrwF5HBDqtfaqAuSsmeX-pDLCi8wJZ2xprHc8IflGVIWL1OVYQaMuxu9xClyYSQAFCriIAk5IOo9aTdQdt_T_gFow90Xi7fECqGMR1bG4TR0TcoA6tLlBXzBEzAZAuUnI4Uavbm5-NTfDEsfvNrYJ7TD2kToDv1Uk5OmkhvNDZgL8V8VgitSOgu68xW5Ls_w50ohzpjSA2Wf_47Wfk3uAJDkG0mTykOytuyG8IHfd7_Wy716Oa_MvUSdDzw priority: 102 providerName: Directory of Open Access Journals – databaseName: Public Library of Science (PLoS) Journals Open Access dbid: FPL link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1bb9MwFLZgIMQLbOOywoaMxANIZJsdx5e9dRUBpDKqiknjKXJsR6sUkqpp4XfxDzlO3LBOmxBvUXyJc27-jn18jNAb5lyilLEgvIJFjMU8yh04rpwlOZGWCG3bW0vG4uxMXlyoyV9H8doOfizIUaDp4byu3CF4D5JRcRfdozHnPoQrnYzXlhd0l_NwPO62lhvTT5ul32c1LevmJoR5PVDyysyTPv7fMW-jRwFj4mEnFDvojqt20YMvYRd9F-0EhW7w25B1-t0T9PtzVYB0dCcZsa4snjrfSwoTX_fK3yaONU6h--g7KAg8lWX9Kzqf41mFwQL5JZ0G-5VdDFAW7AyYU4s_lvUPt_DRrjidlSFLL54Cxj2BTzSrEtr4Qy4YoCj-mverxLp8jyf99WLRKUy3Fo-G0_EQj-pL8BqeovP0w7fRpyjc5xCZhPJlZLTz57M0J875tPk0ZxoAipYsT8CMSB_BAniD2EJplmiqeWyOiQW2AvkKMM3P0FYFFN1D2EppRQFYWxLN7HGhEptQkxilc6WtYQMUr9mcmZDs3N-5UWbtDp4Ap6fjReZZlAUWDVDUt5p3yT7-Uf_US1Bf16fqbl-ALGRB8zPKXEy4A6AgnM-nlrM85qogQAxOjIBO9rz8rT_QZMRjbAUwXg3Q_lomby5-3ReDUfA7Pbpy9aqtwyUFTzcZoOedCPeDpAl4vIIAicSGcG_8xWZJNbtsE48zIiTA3xe3j_glegiIkvmAGsr30dZysXIH6L75uZw1i1ettv4BH6VCcg priority: 102 providerName: Public Library of Science
Title	Inflammation and Renal Function after a Four-Year Follow-Up in Subjects with Unimpaired Glomerular Filtration Rate: Results from the Observational, Population-Based CARLA Cohort
URI	https://www.ncbi.nlm.nih.gov/pubmed/25259714 https://www.proquest.com/docview/1565690209 https://www.proquest.com/docview/1566821485 https://pubmed.ncbi.nlm.nih.gov/PMC4178159 https://doaj.org/article/24e316e3627e4381b4b369f1ae461c77 http://dx.doi.org/10.1371/journal.pone.0108427
Volume	9
WOSCitedRecordID	wos000342685600072&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: DOA dateStart: 20060101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M~E dateStart: 20060101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Advanced Technologies & Aerospace Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: P5Z dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/hightechjournals providerName: ProQuest – providerCode: PRVPQU databaseName: Agricultural Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M0K dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/agriculturejournals providerName: ProQuest – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7P dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Engineering Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7S dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com providerName: ProQuest – providerCode: PRVPQU databaseName: Environmental Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PATMY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/environmentalscience providerName: ProQuest – providerCode: PRVPQU databaseName: Materials Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: KB. dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/materialsscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7RV dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: BENPR dateStart: 20061201 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Health & Medical Collection customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7X7 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database (subscription) customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 8C1 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PIMPY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVATS databaseName: Public Library of Science (PLoS) Journals Open Access customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: FPL dateStart: 20060101 isFulltext: true titleUrlDefault: http://www.plos.org/publications/ providerName: Public Library of Science
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwELfYhhAvwMbHCqMyEg8gka5OnDjhBbXVAtPaEhWGOl4iJ3ZZpZCUpoW_i_-Qu8QNK5rggZdTFH_k487n353tO0Kec63dIEgVCK_gFueOZyUaDFePuwnzFRNSVVlLhmI89qfTIDIOt9Jsq9zoxEpRqyJFH_kxQ-QRALgJ3iy-WZg1CldXTQqNHbKHURJwYEbu540mhrHseea4nCPYseFOZ1HkugN2iM8xl8yV6aiK2o9RTrOivA5x_rlx8spMFN7932-4R-4YDEp7tdDskxs6PyC3RmaV_YDsmwFf0hcmKvXL--TnaT4D6alPOlKZKzrR2EsIE2N9C7ONU0lD6N66gAEEV1lW_LDOF3SeU9BQ6PIpKXp-KUBd0EOgbhV9mxVf9RJ3w9JwnpkovnQCGPg1PKJcZ9AGD8FQgKr0fdJ4kWX2ikZN-jGrD9OxooPeZNijg-ISrIoH5Dw8-Th4Z5l8D1bq2t7KSqXG81vSY1pjWH074RIAjPR54oKa8XGHC-ARpmaB5K60peekXaaAzcDIGajuh2Q3B94eEqp8X4kZYHGfSa66s8BVrp26aSCTQKqUt4izYXucmmDomJMji6sVPgFGUc2LGIUlNsLSIlbTalEHA_lH_T5KVFMXQ3lXN4rll9hohtjm2mGeBiAhNMZbS3jieMGMwc_wWCqgk0OUx80Dyvi3FLXI0UbOri9-1hSD0sCVIJnrYl3V8XwbLGG3RR7VIt28pO2CRSwY_CKxJexbX7Fdks8vq8DknAkf4PHjv7_WE3IbUCfHTTe2d0R2V8u1fkpupt9X83LZJjti8gnpVFTUB-oPWJvs9U_G0aRdOU2AhtEQ6Fm_A3TUPUMqoop-aFdaAFpEp6Po4hdPtmDO
linkProvider	ProQuest
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3fb9MwELamgYAXYOPHCgOMBBJIZJsTx06QEOoKZdW6MlWbVJ6CEzusUkhKszLxTyHxH3KXOIGiCZ72wFsUO47jfL77zj7fEfKEG-OHYaIBvJI7nHvCiQ0YroL7MQs0k0pXWUuGcjQKJpPwcIV8b87CoFtlIxMrQa2LBNfItxkyjxDITfh69sXBrFG4u9qk0KhhsW--nYHJVr4avIH_-9R1-2-PenuOzSrgJL4rTp1EGTwlpAQzBoO3uzFXoCZVwGMfwBygHwVoPabTUHFfuUp4yQ7TIBi4K1OGWSJA5F8COS7RhUxOWgMPqghhj-d5km1bNGzNitxsgd2DDSypvypLAEZVzYryPIb7p6Pmb5qvf-N_G7Ob5Lrl2LRbT4o1smLydXLlwHoRrJM1K9BK-sxG3X5-i_wY5CnMjvokJ1W5pmODrfRB8de3MJs6VbQPzTsf4KvgKsuKM-d4Rqc5BQmMS1olxZVtClQe5CyoE03fZcVnM0dvX9qfZjZKMR0Dx38JrygXGTyDh3woUHH6Pm5XyVX2gh626dWcXaAbmva642GX9ooTsJpuk-MLGcU7ZDUHLG0QqoNAyxRsjYAprnfS0Ne-m_hJqOJQ6YR3iNfALEpssHfMOZJF1Q6mBKOv_hcRgjOy4OwQp31qVgc7-Uf9XURwWxdDlVc3ivmnyEq-yOXGY8IAUZIG48nFPPZEmDIYDMESCY1sIP6bF5TRL9R2yGaD6_OLH7fFIBRxp0vlplhUdUTggqXvd8jdegq1nXR9sPglgyGSS5Nr6SuWS_LpSRV4nTMZAP2_9_duPSJX944OhtFwMNq_T64Bw-boYOSKTbJ6Ol-YB-Ry8vV0Ws4fVtKDko8XPfV-AsIMr2c
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3db9MwELemgSZegI2PFQYYCSSQyDonjp0gIdR1BKqVUlWbNHgJTuywSiEpTcvEn8Urfx13-YKiCZ72wFuUOE7i_O7ud_b5jpBH3BjX92MN4JXc4twRVmTAcRXcjZinmVS6rFoylKORd3Lij9fIj2YvDIZVNjqxVNQ6j3GOvMuQefhAbvxuUodFjA-Cl7MvFlaQwpXWppxGBZFD8-0M3LfixeAA_vVj2w5eHfXfWHWFASt2bbGwYmVwx5ASzBhM5G5HXIHJVB6PXAC2hzEVYAGZTnzFXWUr4cR7TIOS4LZMGFaMAPV_SYKPiY7f2P3QWAFoIkS9Vc-RrFsjY3eWZ2YXfCDsYMUUlhUDMMNqmhfnsd0_gzZ_s4LBtf95_K6TqzX3pr1KWDbJmsm2yMbbOrpgi2zWiq6gT-ps3E9vkO-DLAGpqXZ4UpVpOjHYSwCEoDqFVdapogF0b72Hr4KjNM3PrOMZnWYUNDNOdRUUZ7wpUHzQv2BmNH2d5p_NHKOAaTBN6-zFdALc_zk8olimcA9u_qFA0em7qJ09V-kzOm7Lrln7QEM07fcmwx7t56fgTd0kxxcyirfIega42iZUe56WCfggHlNc7yW-q107dmNfRb7SMe8Qp4FcGNdJ4LEWSRqWK5sSnMHqX4QI1LAGaodY7V2zKgnKP9rvI5rbtpjCvDyRzz-FtUYMbW4cJgwQKGkwz1zEI0f4CYPBECyW0Mk2ykLzgCL8heAO2Wkwfv7lh-1lUJa4AqYyky_LNsKzGffcDrldiVP7krZrg3PNYIjkiqCtfMXqlWx6WiZk50x64Bbc-ftrPSAbIHHhcDA6vEuuAPHmGHdkix2yvpgvzT1yOf66mBbz-6UioeTjRUveT3DxuFo
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Inflammation+and+Renal+Function+after+a+Four-Year+Follow-Up+in+Subjects+with+Unimpaired+Glomerular+Filtration+Rate%3A+Results+from+the+Observational%2C+Population-Based+CARLA+Cohort&rft.jtitle=PloS+one&rft.au=Medenwald%2C+Daniel&rft.au=Girndt%2C+Matthias&rft.au=Loppnow%2C+Harald&rft.au=Kluttig%2C+Alexander&rft.date=2014-09-26&rft.pub=Public+Library+of+Science&rft.eissn=1932-6203&rft.volume=9&rft.issue=9&rft_id=info:doi/10.1371%2Fjournal.pone.0108427&rft_id=info%3Apmid%2F25259714&rft.externalDocID=PMC4178159
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon