Improving the Measurement of Semantic Similarity between Gene Ontology Terms and Gene Products: Insights from an Edge- and IC-Based Hybrid Method

Explicit comparisons based on the semantic similarity of Gene Ontology terms provide a quantitative way to measure the functional similarity between gene products and are widely applied in large-scale genomic research via integration with other models. Previously, we presented an edge-based method,...

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Veröffentlicht in:	PloS one Jg. 8; H. 5; S. e66745
Hauptverfasser:	Wu, Xiaomei, Pang, Erli, Lin, Kui, Pei, Zhen-Ming
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 31.05.2013 Public Library of Science (PLoS)
Schlagworte:	Algorithms Animal models Animals Annotations Biodiversity Bioinformatics Biology C (programming language) Computational Biology - methods Computer Simulation Confidence intervals Conservation Correlation analysis Databases, Genetic Gene expression Gene Ontology Genomes Genomics - methods Humans Internet Laboratories Life sciences Maximum strategies Methods Mice Molecular Sequence Annotation - methods Ontology Programming languages Protein interaction Protein Interaction Maps Proteins ROC Curve Semantics Similarity Similarity measures Beijing China China
ISSN:	1932-6203, 1932-6203
Online-Zugang:	Volltext
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