CYLD Deubiquitinates RIP1 in the TNFα-Induced Necrosome to Facilitate Kinase Activation and Programmed Necrosis

Necroptosis/programmed necrosis is initiated by a macro-molecular protein complex termed the necrosome. Receptor interacting protein kinase 1 (RIPK1/RIP1) and RIP3 are key components of the necrosome. TNFα is a prototypic inducer of necrosome activation, and it is widely believed that deubiquitinati...

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Bibliographic Details
Published in:	PloS one Vol. 8; no. 10; p. e76841
Main Authors:	Moquin, David M., McQuade, Thomas, Chan, Francis Ka-Ming
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 02.10.2013 Public Library of Science (PLoS)
Subjects:	Activation Animals Apoptosis Assembly Cell death Cell Line, Tumor Cloning Cycloheximide Cycloheximide - pharmacology Cysteine Endopeptidases - genetics Cysteine Endopeptidases - metabolism Cytosol Deubiquitinating Enzyme CYLD DIABLO protein Drosophila Enzymes Gene Expression Regulation - drug effects Gene Knockdown Techniques GTPase-Activating Proteins - genetics GTPase-Activating Proteins - metabolism Homeostasis Humans Inflammation Insects Kinases Mice Molecular chains Necroptosis Necrosis Necrosis - genetics Necrosis - metabolism Oligopeptides - pharmacology Pathology Penicillin Phosphorylation Phosphorylation - drug effects Protein kinase Proteins Receptor-Interacting Protein Serine-Threonine Kinases Receptors, Tumor Necrosis Factor, Type I Signal Transduction - drug effects Signaling Tumor necrosis factor receptors Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism Tumor Necrosis Factor-alpha - pharmacology Tumor necrosis factor-TNF Tumor necrosis factor-α Ubiquitin Ubiquitin-protein ligase Ubiquitination Ubiquitination - drug effects United States > US Massachusetts
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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