Associations of NINJ2 Sequence Variants with Incident Ischemic Stroke in the Cohorts for Heart and Aging in Genomic Epidemiology (CHARGE) Consortium
Stroke, the leading neurologic cause of death and disability, has a substantial genetic component. We previously conducted a genome-wide association study (GWAS) in four prospective studies from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and demonstrated tha...
Uložené v:
| Vydané v: | PloS one Ročník 9; číslo 6; s. e99798 |
|---|---|
| Hlavní autori: | , , , , , , , , , , , , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
United States
Public Library of Science
24.06.2014
Public Library of Science (PLoS) |
| Predmet: | |
| ISSN: | 1932-6203, 1932-6203 |
| On-line prístup: | Získať plný text |
| Tagy: |
Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
|
| Abstract | Stroke, the leading neurologic cause of death and disability, has a substantial genetic component. We previously conducted a genome-wide association study (GWAS) in four prospective studies from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and demonstrated that sequence variants near the NINJ2 gene are associated with incident ischemic stroke. Here, we sought to fine-map functional variants in the region and evaluate the contribution of rare variants to ischemic stroke risk.
We sequenced 196 kb around NINJ2 on chromosome 12p13 among 3,986 European ancestry participants, including 475 ischemic stroke cases, from the Atherosclerosis Risk in Communities Study, Cardiovascular Health Study, and Framingham Heart Study. Meta-analyses of single-variant tests for 425 common variants (minor allele frequency [MAF] ≥ 1%) confirmed the original GWAS results and identified an independent intronic variant, rs34166160 (MAF = 0.012), most significantly associated with incident ischemic stroke (HR = 1.80, p = 0.0003). Aggregating 278 putatively-functional variants with MAF≤ 1% using count statistics, we observed a nominally statistically significant association, with the burden of rare NINJ2 variants contributing to decreased ischemic stroke incidence (HR = 0.81; p = 0.026).
Common and rare variants in the NINJ2 region were nominally associated with incident ischemic stroke among a subset of CHARGE participants. Allelic heterogeneity at this locus, caused by multiple rare, low frequency, and common variants with disparate effects on risk, may explain the difficulties in replicating the original GWAS results. Additional studies that take into account the complex allelic architecture at this locus are needed to confirm these findings. |
|---|---|
| AbstractList | Background
Stroke, the leading neurologic cause of death and disability, has a substantial genetic component. We previously conducted a genome-wide association study (GWAS) in four prospective studies from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and demonstrated that sequence variants near the NINJ2 gene are associated with incident ischemic stroke. Here, we sought to fine-map functional variants in the region and evaluate the contribution of rare variants to ischemic stroke risk.
Methods and Results
We sequenced 196 kb around NINJ2 on chromosome 12p13 among 3,986 European ancestry participants, including 475 ischemic stroke cases, from the Atherosclerosis Risk in Communities Study, Cardiovascular Health Study, and Framingham Heart Study. Meta-analyses of single-variant tests for 425 common variants (minor allele frequency [MAF] ≥ 1%) confirmed the original GWAS results and identified an independent intronic variant, rs34166160 (MAF = 0.012), most significantly associated with incident ischemic stroke (HR = 1.80, p = 0.0003). Aggregating 278 putatively-functional variants with MAF≤ 1% using count statistics, we observed a nominally statistically significant association, with the burden of rare NINJ2 variants contributing to decreased ischemic stroke incidence (HR = 0.81; p = 0.026).
Conclusion
Common and rare variants in the NINJ2 region were nominally associated with incident ischemic stroke among a subset of CHARGE participants. Allelic heterogeneity at this locus, caused by multiple rare, low frequency, and common variants with disparate effects on risk, may explain the difficulties in replicating the original GWAS results. Additional studies that take into account the complex allelic architecture at this locus are needed to confirm these findings. BackgroundStroke, the leading neurologic cause of death and disability, has a substantial genetic component. We previously conducted a genome-wide association study (GWAS) in four prospective studies from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and demonstrated that sequence variants near the NINJ2 gene are associated with incident ischemic stroke. Here, we sought to fine-map functional variants in the region and evaluate the contribution of rare variants to ischemic stroke risk.Methods and resultsWe sequenced 196 kb around NINJ2 on chromosome 12p13 among 3,986 European ancestry participants, including 475 ischemic stroke cases, from the Atherosclerosis Risk in Communities Study, Cardiovascular Health Study, and Framingham Heart Study. Meta-analyses of single-variant tests for 425 common variants (minor allele frequency [MAF] ≥ 1%) confirmed the original GWAS results and identified an independent intronic variant, rs34166160 (MAF = 0.012), most significantly associated with incident ischemic stroke (HR = 1.80, p = 0.0003). Aggregating 278 putatively-functional variants with MAF≤ 1% using count statistics, we observed a nominally statistically significant association, with the burden of rare NINJ2 variants contributing to decreased ischemic stroke incidence (HR = 0.81; p = 0.026).ConclusionCommon and rare variants in the NINJ2 region were nominally associated with incident ischemic stroke among a subset of CHARGE participants. Allelic heterogeneity at this locus, caused by multiple rare, low frequency, and common variants with disparate effects on risk, may explain the difficulties in replicating the original GWAS results. Additional studies that take into account the complex allelic architecture at this locus are needed to confirm these findings. Stroke, the leading neurologic cause of death and disability, has a substantial genetic component. We previously conducted a genome-wide association study (GWAS) in four prospective studies from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and demonstrated that sequence variants near the NINJ2 gene are associated with incident ischemic stroke. Here, we sought to fine-map functional variants in the region and evaluate the contribution of rare variants to ischemic stroke risk.BACKGROUNDStroke, the leading neurologic cause of death and disability, has a substantial genetic component. We previously conducted a genome-wide association study (GWAS) in four prospective studies from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and demonstrated that sequence variants near the NINJ2 gene are associated with incident ischemic stroke. Here, we sought to fine-map functional variants in the region and evaluate the contribution of rare variants to ischemic stroke risk.We sequenced 196 kb around NINJ2 on chromosome 12p13 among 3,986 European ancestry participants, including 475 ischemic stroke cases, from the Atherosclerosis Risk in Communities Study, Cardiovascular Health Study, and Framingham Heart Study. Meta-analyses of single-variant tests for 425 common variants (minor allele frequency [MAF] ≥ 1%) confirmed the original GWAS results and identified an independent intronic variant, rs34166160 (MAF = 0.012), most significantly associated with incident ischemic stroke (HR = 1.80, p = 0.0003). Aggregating 278 putatively-functional variants with MAF≤ 1% using count statistics, we observed a nominally statistically significant association, with the burden of rare NINJ2 variants contributing to decreased ischemic stroke incidence (HR = 0.81; p = 0.026).METHODS AND RESULTSWe sequenced 196 kb around NINJ2 on chromosome 12p13 among 3,986 European ancestry participants, including 475 ischemic stroke cases, from the Atherosclerosis Risk in Communities Study, Cardiovascular Health Study, and Framingham Heart Study. Meta-analyses of single-variant tests for 425 common variants (minor allele frequency [MAF] ≥ 1%) confirmed the original GWAS results and identified an independent intronic variant, rs34166160 (MAF = 0.012), most significantly associated with incident ischemic stroke (HR = 1.80, p = 0.0003). Aggregating 278 putatively-functional variants with MAF≤ 1% using count statistics, we observed a nominally statistically significant association, with the burden of rare NINJ2 variants contributing to decreased ischemic stroke incidence (HR = 0.81; p = 0.026).Common and rare variants in the NINJ2 region were nominally associated with incident ischemic stroke among a subset of CHARGE participants. Allelic heterogeneity at this locus, caused by multiple rare, low frequency, and common variants with disparate effects on risk, may explain the difficulties in replicating the original GWAS results. Additional studies that take into account the complex allelic architecture at this locus are needed to confirm these findings.CONCLUSIONCommon and rare variants in the NINJ2 region were nominally associated with incident ischemic stroke among a subset of CHARGE participants. Allelic heterogeneity at this locus, caused by multiple rare, low frequency, and common variants with disparate effects on risk, may explain the difficulties in replicating the original GWAS results. Additional studies that take into account the complex allelic architecture at this locus are needed to confirm these findings. Stroke, the leading neurologic cause of death and disability, has a substantial genetic component. We previously conducted a genome-wide association study (GWAS) in four prospective studies from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and demonstrated that sequence variants near the NINJ2 gene are associated with incident ischemic stroke. Here, we sought to fine-map functional variants in the region and evaluate the contribution of rare variants to ischemic stroke risk. We sequenced 196 kb around NINJ2 on chromosome 12p13 among 3,986 European ancestry participants, including 475 ischemic stroke cases, from the Atherosclerosis Risk in Communities Study, Cardiovascular Health Study, and Framingham Heart Study. Meta-analyses of single-variant tests for 425 common variants (minor allele frequency [MAF] ≥ 1%) confirmed the original GWAS results and identified an independent intronic variant, rs34166160 (MAF = 0.012), most significantly associated with incident ischemic stroke (HR = 1.80, p = 0.0003). Aggregating 278 putatively-functional variants with MAF≤ 1% using count statistics, we observed a nominally statistically significant association, with the burden of rare NINJ2 variants contributing to decreased ischemic stroke incidence (HR = 0.81; p = 0.026). Common and rare variants in the NINJ2 region were nominally associated with incident ischemic stroke among a subset of CHARGE participants. Allelic heterogeneity at this locus, caused by multiple rare, low frequency, and common variants with disparate effects on risk, may explain the difficulties in replicating the original GWAS results. Additional studies that take into account the complex allelic architecture at this locus are needed to confirm these findings. Background Stroke, the leading neurologic cause of death and disability, has a substantial genetic component. We previously conducted a genome-wide association study (GWAS) in four prospective studies from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and demonstrated that sequence variants near the NINJ2 gene are associated with incident ischemic stroke. Here, we sought to fine-map functional variants in the region and evaluate the contribution of rare variants to ischemic stroke risk. Methods and Results We sequenced 196 kb around NINJ2 on chromosome 12p13 among 3,986 European ancestry participants, including 475 ischemic stroke cases, from the Atherosclerosis Risk in Communities Study, Cardiovascular Health Study, and Framingham Heart Study. Meta-analyses of single-variant tests for 425 common variants (minor allele frequency [MAF] ≥ 1%) confirmed the original GWAS results and identified an independent intronic variant, rs34166160 (MAF = 0.012), most significantly associated with incident ischemic stroke (HR = 1.80, p = 0.0003). Aggregating 278 putatively-functional variants with MAF≤ 1% using count statistics, we observed a nominally statistically significant association, with the burden of rare NINJ2 variants contributing to decreased ischemic stroke incidence (HR = 0.81; p = 0.026). Conclusion Common and rare variants in the NINJ2 region were nominally associated with incident ischemic stroke among a subset of CHARGE participants. Allelic heterogeneity at this locus, caused by multiple rare, low frequency, and common variants with disparate effects on risk, may explain the difficulties in replicating the original GWAS results. Additional studies that take into account the complex allelic architecture at this locus are needed to confirm these findings. |
| Author | Hofman, Albert Psaty, Bruce M. DeStefano, Anita Gupta, Mayetri Verhaaren, Benjamin F. J. Boerwinkle, Eric Mosley, Thomas H. Fornage, Myriam Debette, Stéphanie Liu, Xiaoming Brody, Jennifer A. Gottesman, Rebecca F. Gibbs, Richard A. Bis, Joshua C. Ikram, M. Arfan Seshadri, Sudha Muzny, Donna Choi, Seung Hoan Longstreth, W. T. Kovar, Christie L. van Duijn, Cornelia Shahar, Eyal Butler, Kenneth R. Wolf, Philip A. Lumley, Thomas |
| AuthorAffiliation | 7 Department of Epidemiology, University of Versailles Saint-Quentin-en-Yvelines, Paris, France 4 Department of Radiology, Erasmus MC, Rotterdam, The Netherlands 18 Department of Neurology, University of Washington, Seattle, Washington, United States of America 19 Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Texas, United States of America 8 Department of Neurology, Erasmus MC, Rotterdam, The Netherlands (M.A.I.); Netherlands 9 Consortium for Healthy Aging, Leiden, The Netherlands 12 Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America 10 Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona, United States of America 2 Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America 3 Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, United Stat |
| AuthorAffiliation_xml | – name: 1 Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America – name: 13 Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America – name: 9 Consortium for Healthy Aging, Leiden, The Netherlands – name: 16 Department of Statistics, University of Auckland, Auckland, New Zealand – name: 18 Department of Neurology, University of Washington, Seattle, Washington, United States of America – name: 6 Institut National de la Santé et de la Recherche Médicale (INSERM), U708, Neuroepidemiology, Paris, France – name: 12 Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America – name: 5 Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands – name: 17 Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America – name: Inrca, Italy – name: 7 Department of Epidemiology, University of Versailles Saint-Quentin-en-Yvelines, Paris, France – name: 19 Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Texas, United States of America – name: 3 Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, United States of America – name: 2 Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America – name: 8 Department of Neurology, Erasmus MC, Rotterdam, The Netherlands (M.A.I.); Netherlands – name: 15 Group Health Research Institute, Group Health, Seattle, Washington, United States of America – name: 11 Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, Mississippi, United States of America – name: 4 Department of Radiology, Erasmus MC, Rotterdam, The Netherlands – name: 10 Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona, United States of America – name: 14 Department of Epidemiology, University of Washington, Seattle, Washington, United States of America |
| Author_xml | – sequence: 1 givenname: Joshua C. surname: Bis fullname: Bis, Joshua C. – sequence: 2 givenname: Anita surname: DeStefano fullname: DeStefano, Anita – sequence: 3 givenname: Xiaoming surname: Liu fullname: Liu, Xiaoming – sequence: 4 givenname: Jennifer A. surname: Brody fullname: Brody, Jennifer A. – sequence: 5 givenname: Seung Hoan surname: Choi fullname: Choi, Seung Hoan – sequence: 6 givenname: Benjamin F. J. surname: Verhaaren fullname: Verhaaren, Benjamin F. J. – sequence: 7 givenname: Stéphanie surname: Debette fullname: Debette, Stéphanie – sequence: 8 givenname: M. Arfan surname: Ikram fullname: Ikram, M. Arfan – sequence: 9 givenname: Eyal surname: Shahar fullname: Shahar, Eyal – sequence: 10 givenname: Kenneth R. surname: Butler fullname: Butler, Kenneth R. – sequence: 11 givenname: Rebecca F. surname: Gottesman fullname: Gottesman, Rebecca F. – sequence: 12 givenname: Donna surname: Muzny fullname: Muzny, Donna – sequence: 13 givenname: Christie L. surname: Kovar fullname: Kovar, Christie L. – sequence: 14 givenname: Bruce M. surname: Psaty fullname: Psaty, Bruce M. – sequence: 15 givenname: Albert surname: Hofman fullname: Hofman, Albert – sequence: 16 givenname: Thomas surname: Lumley fullname: Lumley, Thomas – sequence: 17 givenname: Mayetri surname: Gupta fullname: Gupta, Mayetri – sequence: 18 givenname: Philip A. surname: Wolf fullname: Wolf, Philip A. – sequence: 19 givenname: Cornelia surname: van Duijn fullname: van Duijn, Cornelia – sequence: 20 givenname: Richard A. surname: Gibbs fullname: Gibbs, Richard A. – sequence: 21 givenname: Thomas H. surname: Mosley fullname: Mosley, Thomas H. – sequence: 22 givenname: W. T. surname: Longstreth fullname: Longstreth, W. T. – sequence: 23 givenname: Eric surname: Boerwinkle fullname: Boerwinkle, Eric – sequence: 24 givenname: Sudha surname: Seshadri fullname: Seshadri, Sudha – sequence: 25 givenname: Myriam surname: Fornage fullname: Fornage, Myriam |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24959832$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9Ul1v0zAUjdAQ-4B_gMASL-Ohxd-J94BUVaUtmobEgFfLcZzUJbGLnTDtf-wH464t2ibEk6_sc47PvfecZkfOO5NlrxEcI5KjD2s_BKfa8SZdjyEUIhfFs-wECYJHHENy9KA-zk5jXEPISMH5i-wYU8FEQfBJdjeJ0WureutdBL4GV8urzxhcm1-DcdqAHypY5foIbmy_AkunbWVcD5ZRr0xnNbjug_9pgHWgXxkw9SsfErj2ASyMCj1QrgKTxrpmC5kb57ek2SapdNa3vrkF59PF5Ot89j6RXUxsO3Qvs-e1aqN5tT_Psu-fZt-mi9Hll_lyOrkcaYZ5P1JGE4EE0wopljPOqRAF1IalQtUlKRGujCA1oVrnnKOqqI2gXMGSC1Km_s-ytzvdTeuj3A80SsSIyBmiiCbEcoeovFrLTbCdCrfSKyvvL3xoZOrS6tZIzCkrCl5rzjClhBZpSzmq8zIXJcE5TFof978NZWcqneYYVPtI9PGLsyvZ-N-SQi4gIkngfC8QfFpP7GVnozZtq5zxw9Y3hTnCWOAEffcE-u_u3jx09NfKIR4JcLED6OBjDKaW2vb3WUkGbSsRlNssHsTlNotyn8VEpk_IB_3_0v4AoMTlZg |
| CitedBy_id | crossref_primary_10_1177_1352458519851428 crossref_primary_10_1186_s40364_025_00792_0 crossref_primary_10_3390_ijms17091402 crossref_primary_10_1007_s11886_016_0804_z crossref_primary_10_1016_j_cellsig_2017_04_011 crossref_primary_10_3390_genes13111946 crossref_primary_10_1007_s10072_019_04023_x crossref_primary_10_1515_med_2023_0655 |
| Cites_doi | 10.1093/bioinformatics/btq340 10.1001/jama.296.24.2939 10.1523/JNEUROSCI.1103-06.2006 10.1002/humu.21517 10.1161/01.STR.28.7.1361 10.1016/S1474-4422(12)70234-X 10.1186/1423-0127-19-1 10.1056/NEJMc0910050 10.1161/CIR.0b013e31828124ad 10.1016/1047-2797(93)90105-D 10.1161/STROKEAHA.110.594010 10.1161/01.CIR.0000018650.58984.75 10.1101/gr.136127.111 10.1056/NEJMoa0900094 10.1371/journal.pone.0007767 10.1161/01.STR.28.10.1908 10.1212/WNL.56.3.368 10.1371/journal.pbio.0060107 10.1101/gr.137323.112 10.1186/1756-0500-5-155 10.1093/bioinformatics/btp352 10.1161/01.STR.30.4.736 10.1371/journal.pbio.1000294 10.1016/j.ajhg.2011.05.029 10.1093/nar/gkq603 10.1073/pnas.1322563111 10.1161/01.STR.0000199613.38911.b2 10.1016/j.jns.2012.01.010 10.1161/hs0302.103619 10.1161/CIRCGENETICS.108.829747 10.1038/nature11247 10.1038/jhg.2010.45 |
| ContentType | Journal Article |
| Copyright | 2014 Bis et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2014 Bis et al 2014 Bis et al |
| Copyright_xml | – notice: 2014 Bis et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2014 Bis et al 2014 Bis et al |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QG 7QL 7QO 7RV 7SN 7SS 7T5 7TG 7TM 7U9 7X2 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M7N M7P M7S NAPCQ P5Z P62 P64 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PTHSS PYCSY RC3 7X8 5PM DOA |
| DOI | 10.1371/journal.pone.0099798 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts Nursing & Allied Health Database Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Meteorological & Geoastrophysical Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Materials Science & Engineering ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Computer Science Collection Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection ProQuest Central Technology Collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One ProQuest Materials Science Collection ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection Biological Sciences Agricultural Science Database ProQuest Health & Medical Collection Medical Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Nursing & Allied Health Premium ProQuest advanced technologies & aerospace journals ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Materials Science Collection (ProQuest) ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition Engineering Collection Environmental Science Collection (ProQuest) Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database Publicly Available Content Database ProQuest Central Student ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Materials Science Collection ProQuest Public Health ProQuest Nursing & Allied Health Source ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE Agricultural Science Database |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Sciences (General) Medicine Public Health |
| DocumentTitleAlternate | NINJ2 Sequencing in Ischemic Stroke |
| EISSN | 1932-6203 |
| ExternalDocumentID | 1539751414 oai_doaj_org_article_2645886fc6524434813771f7b79b3270 PMC4069013 3348378721 24959832 10_1371_journal_pone_0099798 |
| Genre | Meta-Analysis Research Support, American Recovery and Reinvestment Act Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NHLBI NIH HHS grantid: N01 HC085082 – fundername: NHLBI NIH HHS grantid: N01 HC055222 – fundername: NIA NIH HHS grantid: AG20098 – fundername: NHLBI NIH HHS grantid: HHSN268201100007C – fundername: NHLBI NIH HHS grantid: N02-HL-6-4278 – fundername: NHLBI NIH HHS grantid: HHSN268201100005G – fundername: NIA NIH HHS grantid: R56 AG023629 – fundername: NHLBI NIH HHS grantid: 5RC2HL102419 – fundername: NHLBI NIH HHS grantid: N01 HC025195 – fundername: NHLBI NIH HHS grantid: R01 HL103612 |
| GroupedDBID | --- 123 29O 2WC 53G 5VS 7RV 7X2 7X7 7XC 88E 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ AAUCC AAWOE AAYXX ABDBF ABIVO ABJCF ABUWG ACCTH ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV ADRAZ AEAQA AENEX AEUYN AFFHD AFKRA AFPKN AFRAH AHMBA ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ARAPS ATCPS BAWUL BBNVY BCNDV BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI BWKFM CCPQU CITATION CS3 D1I D1J D1K DIK DU5 E3Z EAP EAS EBD EMOBN ESX EX3 F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IEA IGS IHR IHW INH INR IOV IPY ISE ISR ITC K6- KB. KQ8 L6V LK5 LK8 M0K M1P M48 M7P M7R M7S M~E NAPCQ O5R O5S OK1 OVT P2P P62 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PTHSS PYCSY RNS RPM SV3 TR2 UKHRP WOQ WOW ~02 ~KM ALIPV CGR CUY CVF ECM EIF IPNFZ NPM PV9 RIG RZL 3V. 7QG 7QL 7QO 7SN 7SS 7T5 7TG 7TM 7U9 7XB 8FD 8FK AZQEC C1K DWQXO ESTFP FR3 GNUQQ H94 K9. KL. M7N P64 PKEHL PQEST PQUKI RC3 7X8 PUEGO 5PM - 02 AAPBV ABPTK ADACO BBAFP BBORY KM |
| ID | FETCH-LOGICAL-c526t-aec39195ca1a5756649980ce5649afb3b12de93f34cc7661d8fe946a0b693b983 |
| IEDL.DBID | P5Z |
| ISICitedReferencesCount | 9 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000338633900015&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1932-6203 |
| IngestDate | Sun May 01 00:10:47 EDT 2022 Fri Oct 03 12:46:40 EDT 2025 Tue Nov 04 01:58:18 EST 2025 Mon Sep 08 07:27:27 EDT 2025 Tue Oct 07 07:45:11 EDT 2025 Mon Jul 21 06:05:54 EDT 2025 Sat Nov 29 03:54:47 EST 2025 Tue Nov 18 21:15:43 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 6 |
| Language | English |
| License | This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. Creative Commons Attribution License |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c526t-aec39195ca1a5756649980ce5649afb3b12de93f34cc7661d8fe946a0b693b983 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Undefined-3 Competing Interests: Bruce M.Psaty serves on the DSMB of a clinical trial of a device funded by Zoll LifeCor. The Framingham Heart Study is conducted and supported by the NHLBI in collaboration with Boston University (Contract No. N01-HC-25195), and its contract with Affymetrix, Inc., for genome-wide genotyping services (Contract No. N02-HL-6-4278). This study did not receive support from Affymetrix. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials. Conceived and designed the experiments: JCB AD BMP RAG THM WTL EB SS MF. Performed the experiments: DM CLK. Analyzed the data: JCB AD JAB XL SHC MG MF. Contributed reagents/materials/analysis tools: JAB MG TL XL. Wrote the paper: JCB AD SS BMP WTL THM EB BFJV SD MAI ES KRB RFG PAW CvD AH MF. |
| OpenAccessLink | https://www.proquest.com/docview/1539751414?pq-origsite=%requestingapplication% |
| PMID | 24959832 |
| PQID | 1539751414 |
| PQPubID | 1436336 |
| ParticipantIDs | plos_journals_1539751414 doaj_primary_oai_doaj_org_article_2645886fc6524434813771f7b79b3270 pubmedcentral_primary_oai_pubmedcentral_nih_gov_4069013 proquest_miscellaneous_1540712292 proquest_journals_1539751414 pubmed_primary_24959832 crossref_citationtrail_10_1371_journal_pone_0099798 crossref_primary_10_1371_journal_pone_0099798 |
| PublicationCentury | 2000 |
| PublicationDate | 2014-06-24 |
| PublicationDateYYYYMMDD | 2014-06-24 |
| PublicationDate_xml | – month: 06 year: 2014 text: 2014-06-24 day: 24 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: San Francisco – name: San Francisco, USA |
| PublicationTitle | PloS one |
| PublicationTitleAlternate | PLoS One |
| PublicationYear | 2014 |
| Publisher | Public Library of Science Public Library of Science (PLoS) |
| Publisher_xml | – name: Public Library of Science – name: Public Library of Science (PLoS) |
| References | WD Rosamond (ref18) 1999; 30 N Homer (ref22) 2009; 4 M Hollander (ref16) 2002; 105 S Olsson (ref8) 2011; 42 DE Kim (ref12) 2012; 5 S Bak (ref2) 2002; 33 P Jousilahti (ref3) 1997; 28 EP Consortium (ref32) 2012; 489 S Seshadri (ref20) 2006; 37 D Liao (ref4) 1997; 28 EE Schadt (ref29) 2008; 6 TR Price (ref19) 1993; 3 MC Wu (ref28) 2011; 89 MA Ikram (ref5) 2009; 360 YC Hsieh (ref10) 2012; 19 C International Stroke Genetics (ref7) 2010; 362 BH Li (ref11) 2012; 316 T Matsushita (ref13) 2010; 55 PA Wolf (ref21) 1978; 19 BM Psaty (ref14) 2009; 2 WT Longstreth Jr (ref17) 2001; 56 H Li (ref23) 2009; 25 M Traylor (ref9) 2012; 11 O Zuk (ref33) 2014; 111 R Carandang (ref15) 2006; 296 SP Dickson (ref30) 2010; 8 K Wang (ref24) 2010; 38 AP Boyle (ref27) 2012; 22 MA Schaub (ref31) 2012; 22 AS Go (ref1) 2013; 127 X Liu (ref25) 2011; 32 CJ Willer (ref26) 2010; 26 L Dimou (ref6) 2006; 26 |
| References_xml | – volume: 19 start-page: 107 year: 1978 ident: ref21 article-title: Prospective investigations: the Framingham study and the epidemiology of stroke publication-title: Adv Neurol – volume: 26 start-page: 2190 year: 2010 ident: ref26 article-title: METAL: fast and efficient meta-analysis of genomewide association scans publication-title: Bioinformatics doi: 10.1093/bioinformatics/btq340 – volume: 296 start-page: 2939 year: 2006 ident: ref15 article-title: Trends in incidence, lifetime risk, severity, and 30-day mortality of stroke over the past 50 years publication-title: Jama doi: 10.1001/jama.296.24.2939 – volume: 26 start-page: 5591 year: 2006 ident: ref6 article-title: Nogo-A-deficient mice reveal strain-dependent differences in axonal regeneration publication-title: J Neurosci doi: 10.1523/JNEUROSCI.1103-06.2006 – volume: 32 start-page: 894 year: 2011 ident: ref25 article-title: dbNSFP: a lightweight database of human nonsynonymous SNPs and their functional predictions publication-title: Hum Mutat doi: 10.1002/humu.21517 – volume: 28 start-page: 1361 year: 1997 ident: ref3 article-title: Parental history of cardiovascular disease and risk of stroke. A prospective follow-up of 14371 middle-aged men and women in Finland publication-title: Stroke doi: 10.1161/01.STR.28.7.1361 – volume: 11 start-page: 951 year: 2012 ident: ref9 article-title: Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE Collaboration): a meta-analysis of genome-wide association studies publication-title: Lancet neurology doi: 10.1016/S1474-4422(12)70234-X – volume: 19 start-page: 1 year: 2012 ident: ref10 article-title: Association between genetic variant on chromosome 12p13 and stroke survival and recurrence: a one year prospective study in Taiwan publication-title: J Biomed Sci doi: 10.1186/1423-0127-19-1 – volume: 362 start-page: 1547 year: 2010 ident: ref7 article-title: Failure to validate association between 12p13 variants and ischemic stroke publication-title: N Engl J Med doi: 10.1056/NEJMc0910050 – volume: 127 start-page: e6 year: 2013 ident: ref1 article-title: Heart disease and stroke statistics–2013 update: a report from the American Heart Association publication-title: Circulation doi: 10.1161/CIR.0b013e31828124ad – volume: 3 start-page: 504 year: 1993 ident: ref19 article-title: Assessment of cerebrovascular disease in the Cardiovascular Health Study publication-title: Ann Epidemiol doi: 10.1016/1047-2797(93)90105-D – volume: 42 start-page: 214 year: 2011 ident: ref8 article-title: Genetic variant on chromosome 12p13 does not show association to ischemic stroke in 3 Swedish case-control studies publication-title: Stroke doi: 10.1161/STROKEAHA.110.594010 – volume: 105 start-page: 2872 year: 2002 ident: ref16 article-title: Carotid plaques increase the risk of stroke and subtypes of cerebral infarction in asymptomatic elderly: the Rotterdam study publication-title: Circulation doi: 10.1161/01.CIR.0000018650.58984.75 – volume: 22 start-page: 1748 year: 2012 ident: ref31 article-title: Linking disease associations with regulatory information in the human genome publication-title: Genome Res doi: 10.1101/gr.136127.111 – volume: 360 start-page: 1718 year: 2009 ident: ref5 article-title: Genomewide association studies of stroke publication-title: N Engl J Med doi: 10.1056/NEJMoa0900094 – volume: 4 start-page: e7767 year: 2009 ident: ref22 article-title: BFAST: an alignment tool for large scale genome resequencing publication-title: PLoS ONE doi: 10.1371/journal.pone.0007767 – volume: 28 start-page: 1908 year: 1997 ident: ref4 article-title: Familial history of stroke and stroke risk. The Family Heart Study publication-title: Stroke doi: 10.1161/01.STR.28.10.1908 – volume: 56 start-page: 368 year: 2001 ident: ref17 article-title: Frequency and predictors of stroke death in 5,888 participants in the Cardiovascular Health Study publication-title: Neurology doi: 10.1212/WNL.56.3.368 – volume: 6 start-page: e107 year: 2008 ident: ref29 article-title: Mapping the genetic architecture of gene expression in human liver publication-title: PLoS Biol doi: 10.1371/journal.pbio.0060107 – volume: 22 start-page: 1790 year: 2012 ident: ref27 article-title: Annotation of functional variation in personal genomes using RegulomeDB publication-title: Genome Res doi: 10.1101/gr.137323.112 – volume: 5 start-page: 155 year: 2012 ident: ref12 article-title: NINJ2 SNP may affect the onset age of first-ever ischemic stroke without increasing silent cerebrovascular lesions publication-title: BMC Res Notes doi: 10.1186/1756-0500-5-155 – volume: 25 start-page: 2078 year: 2009 ident: ref23 article-title: The Sequence Alignment/Map format and SAMtools publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp352 – volume: 30 start-page: 736 year: 1999 ident: ref18 article-title: Stroke incidence and survival among middle-aged adults: 9-year follow-up of the Atherosclerosis Risk in Communities (ARIC) cohort publication-title: Stroke doi: 10.1161/01.STR.30.4.736 – volume: 8 start-page: e1000294 year: 2010 ident: ref30 article-title: Rare variants create synthetic genome-wide associations publication-title: PLoS Biol doi: 10.1371/journal.pbio.1000294 – volume: 89 start-page: 82 year: 2011 ident: ref28 article-title: Rare-variant association testing for sequencing data with the sequence kernel association test publication-title: Am J Hum Genet doi: 10.1016/j.ajhg.2011.05.029 – volume: 38 start-page: e164 year: 2010 ident: ref24 article-title: ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data publication-title: Nucleic Acids Res doi: 10.1093/nar/gkq603 – volume: 111 start-page: E455 year: 2014 ident: ref33 article-title: Searching for missing heritability: designing rare variant association studies publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.1322563111 – volume: 37 start-page: 345 year: 2006 ident: ref20 article-title: The lifetime risk of stroke: estimates from the Framingham Study publication-title: Stroke doi: 10.1161/01.STR.0000199613.38911.b2 – volume: 316 start-page: 116 year: 2012 ident: ref11 article-title: Association between 12p13 SNPs rs11833579/rs12425791 near NINJ2 gene and ischemic stroke in East Asian population: evidence from a meta-analysis publication-title: J Neurol Sci doi: 10.1016/j.jns.2012.01.010 – volume: 33 start-page: 769 year: 2002 ident: ref2 article-title: Genetic liability in stroke: a long-term follow-up study of Danish twins publication-title: Stroke doi: 10.1161/hs0302.103619 – volume: 2 start-page: 73 year: 2009 ident: ref14 article-title: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium: Design of Prospective Meta-Analyses of Genome-Wide Association Studies From 5 Cohorts publication-title: Circ Cardiovasc Genet doi: 10.1161/CIRCGENETICS.108.829747 – volume: 489 start-page: 57 year: 2012 ident: ref32 article-title: An integrated encyclopedia of DNA elements in the human genome publication-title: Nature doi: 10.1038/nature11247 – volume: 55 start-page: 473 year: 2010 ident: ref13 article-title: Association study of the polymorphisms on chromosome 12p13 with atherothrombotic stroke in the Japanese population publication-title: J Hum Genet doi: 10.1038/jhg.2010.45 |
| SSID | ssj0053866 |
| Score | 2.2008615 |
| SecondaryResourceType | review_article |
| Snippet | Stroke, the leading neurologic cause of death and disability, has a substantial genetic component. We previously conducted a genome-wide association study... Background Stroke, the leading neurologic cause of death and disability, has a substantial genetic component. We previously conducted a genome-wide association... BackgroundStroke, the leading neurologic cause of death and disability, has a substantial genetic component. We previously conducted a genome-wide association... Background Stroke, the leading neurologic cause of death and disability, has a substantial genetic component. We previously conducted a genome-wide association... |
| SourceID | plos doaj pubmedcentral proquest pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | e99798 |
| SubjectTerms | Aging Arteriosclerosis Atherosclerosis Bioinformatics Cardiovascular diseases Cell Adhesion Molecules, Neuronal - genetics Chromosome 12 Consortia Epidemiology Female Gene expression Gene frequency Genetic Association Studies - methods Genetic Heterogeneity Genetics Genome-wide association studies Genomes Geriatrics Health risks Heart Heterogeneity Humans Introns Ischemia Ischemia - genetics Loci Male Medical research Medicine Medicine and Health Sciences Meta-analysis Myocardial Infarction - etiology Myocardial Infarction - genetics Neurology Polymorphism, Single Nucleotide Prospective Studies Public health Replication Risk Science Sequence Analysis, DNA Statistical analysis Stroke Studies White People - genetics |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9NAEF6higMXRHk1UNAgcWgPbm3veh_HEKUEDhFCIPVm7a7XakSxq9ipxP_gBzPjR0hQpV64RZ611p5H5hvvPBh7bxCFOON1FLvYRkLqGE0qLiIrnctSjy630N2wCbVc6stL82Vn1BflhPXtgXvGnaPDzrSWpZcZeiIqG-VKJaVyyjieqi5ax_3GYKr_D0YrlnIolOMqOR_kcnZTV-GMQJEyes8Rdf36qb_pdd3chTX_TZnc8UEXT9jjATzCtH_oQ_YgVE_Z4WCeDZwMPaRPn7HfO2xvoC5h-Wn5OYUxcRpuMUSmDBig77BA39upYBdWGOtStjw07br-EZAACBBhVl_RwQIgwIUFmkYLtipgSvONaAluS7XNMP87bfYXnMwW068f56eAAXeDd682P5-z7xfzb7NFNAxgiHyWyjaywXOTmMzbxCKskxLDIx37kOEPWzrukrQIhpdceK_Q0Re6DEZIGztpuDOav2AHFbL8iEEpgyiV8kg3wguBqChIaVWhikL6Qk0YH6WR-6E7OQ3JuM67IzeFUUrP45xkmA8ynLBoe9dN353jnvUfSNDbtdRbu7uAGpcPGpffp3ETdkRqMm7Q5Og0jELgmYgJOx5V527yuy0ZrZiOZmwV6g2tocA6TU06YS97Tds-JE0HR14iRe3p4N5b7FOq1VXXKZzKmhHjv_ofr_2aPUKwKChNLhXH7KBdb8Ib9tDftqtm_bYzvz8b2jS7 priority: 102 providerName: Directory of Open Access Journals – databaseName: Public Library of Science (PLoS) Journals Open Access dbid: FPL link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3db9MwELdgIISEgJWPBQY6JB62h4wkTuz4sVQtG4JqYoD2FjmOo1XbkqlJkfg_-IO5S9xunTYh3qLYlh3fnf273Bdj7xWikFyZ1A_yQPuxSAMUqaDwtcjzJDJ45RZpV2xCTqfp8bE6vFQUr1nwuQw_uD3du6gru0eARqr0LrsXcSHIhWty-GV58qLsCuHC424buXb9dFn6KavpWd3chDCvO0peuXkmT_53zU_ZY4cxYdgzxSa7Y6sBe_DVWdEH7FH_rw76EKQB23QC3sCOy0K9-4z9uUK4BuoSpgfTzxEcOddr-IlKNvnQAP3JBTxmqDppCweoLZO_PRy18_rUwqwChJgwqk_INAEIkWnaeQu6KmBIFZKoC05L0dEwvqxX-xt2RvvDb5_Gu0BFRXH0bHH-nP2YjL-P9n1XwsE3SSRaX1vDVagSo0ONwFAIVLDSwNgEH3SZ8zyMCqt4yWNjJEKFIi2tioUOcqF4rlL-gm1UuIlbDEph41JKg-0qNnGMuMoKoWUhi0KYQnqMLymbGZffnMpsnGWd0U6intNvf0ZUyRxVPOavRl30-T3-0f8jMc2qL2Xn7l4g-TMn7BmCzCRNRWlEguiJQp25lGEpc6lyHsnAY1vEcssJmgyvHSURuoaxx7aXbHhz87tVM54DZNzRla0X1IdU8yhSkcde9ly7WiTVF8e9xBa5xs9rX7HeUs1OulzjFBiNWsKr21f8mj1EEBmT-1wUb7ONdr6wb9h986udNfO3nYD-BdnNOxg priority: 102 providerName: Public Library of Science |
| Title | Associations of NINJ2 Sequence Variants with Incident Ischemic Stroke in the Cohorts for Heart and Aging in Genomic Epidemiology (CHARGE) Consortium |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/24959832 https://www.proquest.com/docview/1539751414 https://www.proquest.com/docview/1540712292 https://pubmed.ncbi.nlm.nih.gov/PMC4069013 https://doaj.org/article/2645886fc6524434813771f7b79b3270 http://dx.doi.org/10.1371/journal.pone.0099798 |
| Volume | 9 |
| WOSCitedRecordID | wos000338633900015&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: DOA dateStart: 20060101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M~E dateStart: 20060101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Advanced Technologies & Aerospace Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: P5Z dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/hightechjournals providerName: ProQuest – providerCode: PRVPQU databaseName: Agricultural Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M0K dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/agriculturejournals providerName: ProQuest – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7P dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Engineering Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7S dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com providerName: ProQuest – providerCode: PRVPQU databaseName: Environmental Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PATMY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/environmentalscience providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7X7 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Materials Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: KB. dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/materialsscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7RV dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: BENPR dateStart: 20061201 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database (ProQuest) customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 8C1 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PIMPY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVATS databaseName: Public Library of Science (PLoS) Journals Open Access customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: FPL dateStart: 20060101 isFulltext: true titleUrlDefault: http://www.plos.org/publications/ providerName: Public Library of Science |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9NAEF7RFiEkBDQ8GijRInFoD0793McJJVFCQ0lkJVClXCx7bdOIYofYQeJ_8IOZsTdpgyo4cBlF2V2t7Z2d_WbnRcgbCSgkkkoYZmSGhsuECVvKjI2QRZFnKzhyY1EVm-DjsZjNpK8v3ArtVrmWiZWgjnOFd-QnsDMlh9Pdct8uvhtYNQqtq7qExg7ZwywJuDF97_NaEsNeZkyHyzncOtGr017kWdJGaMSl2DqOqqz9mOX0Ki9uQ5x_Ok7eOIkGj_73HR6ThxqD0k7NNPvkTpI1yL2RtrI3yIP6Lo_WIUoNsq8FQEGPdJbq4yfk142FLWie0vFw_N6mU-2aTc9BCUcfG4o3vRTEEFYvLekQtGn0x6fTcpl_Teg8owBBaS-_RNMFBQiN0y5LGmYx7WAFJewC02L0NO1f17P9SY96p53Ju_4xxaKjMHq--vaUfBr0P_ZODV3iwVCezUojTJQjLemp0AoBODIGCpgwVeLBjzCNnMiy40Q6qeMqxQFKxCJNpMtCM2LSiaRwnpHdDJbzgNCUJW7KuYJ26SrXBdyVMBbymMcxUzFvEme90oHS-c-xDMdVUBn1OOhB9ecPkD8CzR9NYmxGLer8H__o30Um2vTF7N3VH_nyS6CFQQAg1BOCpYp5gK4wFNrh3Ep5xGXk2NxskgNkwfUERXDNOE1yuGat25tfb5pBTqDxJ8ySfIV9UHW3bWk3yfOaizcPifXH4VtCC9_i76232G7J5pdVLnIMnAYt4sXfH-sluQ9A00UXO9s9JLvlcpW8InfVj3JeLFtkh0_Okc54RQVQ0bNaZK_bH_uTVnVPAnTgfwB61m0DHZlnSLlf0Wmr2vgwwh-O_IvfQslZRg |
| linkProvider | ProQuest |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Nb9NAEB2VggAJAQ2FBgosEkjtwa0_d70HhEJISWgbIVpQbq69XtOIYofYAfV_8Dv4jcz4I21QBaceuEXZdWxv3sy-3Z2ZB_BcIguJpPINMzJDw-W-iSZlxkbIo8izFU65sV-KTYjh0B-N5Psl-NXkwlBYZeMTS0cdZ4r2yLfRMqXA2d1yX02-GaQaRaerjYRGBYtdffoDl2z5y8Eb_H9f2PZO77DbN2pVAUN5Ni-MUCtHWtJToRUiV-EcOb9vKu3hhzCJnMiyYy2dxHGVEjh7xX6ipctDM-LSiaTv4O9egavoxwWFkInRfIGHvoPzOj3PEdZ2jYatSZbqLaJiQvoL01-pEkBVVU-y_CKG-2eg5rmZb-fO_zZmd-F2zbFZpzKKFVjSaQuu79dRBC24Ve1VsioFqwUrtYPL2UZdhXvzHvw8B9ycZQkbDobvbHZQh56zTyGablrkjHayGbpZUmct2CBXZQkGdlBMsy-ajVOGFJt1s2M6mmG4RKDbTgsWpjHrkEIUdcHbUnY4653p9Z6yjW6_8-Ftb5ORqCpePZ59XYWPlzJw92E5RfisAUu4dhMhFLZLV7ku8krNeShiEcdcxaINToOsQNX13Ulm5CQoDy0FrvOq4Q8Ij0GNxzYY86smVX2Tf_R_TaCd96Xq5OUX2fRzUDu7AEm25_s8UdxD9kip3o4QViIiISPHFmYb1gjyzQ3y4AyobVhvoHxx87N5M_pBOtwKU53NqA9tTdi2tNvwoLKa-UOSvjqOJbaIBXtaeIvFlnR8XNZap8RwXCU9_PtjPYUb_cP9vWBvMNx9BDeRVLsUTmi767BcTGf6MVxT34txPn1SOgwGR5dtbb8Bfouo_w |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1bb9MwFLbGQBMSAlYuKwwwEkjbQ9Zc7fgBodK1rAyqigGaeAmO47CKkZQmBe1_8Gv4dZyTON2KJnjaA29V7TSJ-51zvmOfCyFPBLCQWKjQsmNbWj4LbRApO7Eki-PAVWByk7BqNsFHo_DwUIxXyK8mFwbDKhudWCnqJFe4R94ByRQcrLvjd1ITFjHeHTyffrOwgxSetDbtNGqI7OuTH-C-Fc-Gu_BfP3XdQf9db88yHQYsFbistKRWnnBEoKQjgbcwBvw_tJUO4INMYy923EQLL_V8pThYsiRMtfCZtGMmvFiEHvzuJXKZg4-Jjt84-NhYAdAjjJlUPY87HYOMnWme6R2kZVyES6aw6hiAFVaP8-I8tvtn0OYZKzi48T-v301y3XBv2q2FZZ2s6KxF1t6Y6IIWuVbvYdI6NatF1o3iK-iWqc69fYv8PAPoguYpHQ1Hr1x6YELS6QcJIp2VBcUdbgrqF7u2lnRYqKo0Az0oZ_kXTScZBepNe_kRHtlQcB3wtrOSyiyhXewchVPgtpg1TvunfXxP6FZvr_v2ZX-bYrNVuHoy_3qbvL-QhbtDVjOA0gahKdN-yrmCceEr3we-qRmTPOFJwlTC28RrUBYpU_cd248cR9VhJgf_r17-CLEZGWy2ibW4alrXPfnH_BcI4MVcrFpefZHPPkdGCUZAvoMwZKliAbBKTAH3OHdSHnMRey6322QD4d_coIhOQdsmmw2szx9-vBgG_YiHXjLT-Rzn4JaF6wq3Te7WErR4SOy7DmsJI3xJtpbeYnkkmxxVNdgxYRy8p3t_f6xHZA2ELHo9HO3fJ1eBa_sYZej6m2S1nM31A3JFfS8nxexhpTso-XTRwvYbvxKx8g |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Associations+of+NINJ2+sequence+variants+with+incident+ischemic+stroke+in+the+Cohorts+for+Heart+and+Aging+in+Genomic+Epidemiology+%28CHARGE%29+consortium&rft.jtitle=PloS+one&rft.au=Bis%2C+Joshua+C&rft.au=DeStefano%2C+Anita&rft.au=Liu%2C+Xiaoming&rft.au=Brody%2C+Jennifer+A&rft.date=2014-06-24&rft.eissn=1932-6203&rft.volume=9&rft.issue=6&rft.spage=e99798&rft_id=info:doi/10.1371%2Fjournal.pone.0099798&rft_id=info%3Apmid%2F24959832&rft.externalDocID=24959832 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon |