Comparison of Early Changes in Ocular Surface and Inflammatory Mediators between Femtosecond Lenticule Extraction and Small-Incision Lenticule Extraction
To evaluate the short-term changes in ocular surface measures and tear inflammatory mediators after femtosecond lenticule extraction (FLEx) and small-incision lenticule extraction (SMILE) procedures. Eighteen subjects (18 eyes) underwent FLEx and 23 subjects (23 eyes) underwent SMILE in this single-...
Gespeichert in:
| Veröffentlicht in: | PloS one Jg. 11; H. 3; S. e0149503 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
United States
Public Library of Science
03.03.2016
Public Library of Science (PLoS) |
| Schlagworte: | |
| ISSN: | 1932-6203, 1932-6203 |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | To evaluate the short-term changes in ocular surface measures and tear inflammatory mediators after femtosecond lenticule extraction (FLEx) and small-incision lenticule extraction (SMILE) procedures.
Eighteen subjects (18 eyes) underwent FLEx and 23 subjects (23 eyes) underwent SMILE in this single-center and prospective study. Central corneal sensitivity, Schirmer I test (SIT), noninvasive tear breakup time (NI-TBUT), tear meniscus height, corneal fluorescein (FL) staining, and ocular surface disease index (OSDI) were assessed in all patients. Concentrations of interleukin-1α (IL-1α), tumor necrosis factor-α (TNF-α), nerve growth factor (NGF), interferon-γ (IFN-γ), transforming growth factor-β1 (TGF-β1) and matrix metalloproteinase-9 (MMP-9) in collected tears were measured by multiplex antibody microarray.
Central corneal sensitivity was reduced in both groups, but the scores in the SMILE group were higher than those in the FLEx group at all time points postoperatively (P<0.01). Lower FL scores and longer NI-BUT were observed in the SMILE group 1 week after surgery (P<0.05). OSDI scores in both groups increased rapidly at 1 day and 1 week postoperatively, then returned to their preoperative levels within 1 month (P<0.05). There were no significant differences in SIT or tear meniscus height between the two groups. Lower and faster recovery of tear NGF, TGF-β1 and IL-1α concentration were found in the SMILE group compared to the FLEx group postoperatively. No significant difference was found in tear TNF-α, IFN-γ and MMP-9 for either group before or after surgery. Tear NGF, TGF-β1 and IL-1α show a correlation with ocular surface changes after FLEx or SMILE surgery.
SMILE has superiority over FLEx in early ocular surface changes and NGF, TGF-β1 and IL-1α may contribute to the process of ocular surface recovery.
ClinicalTrials.gov NCT02540785. |
|---|---|
| AbstractList | Purpose
To evaluate the short-term changes in ocular surface measures and tear inflammatory mediators after femtosecond lenticule extraction (FLEx) and small-incision lenticule extraction (SMILE) procedures.
Methods
Eighteen subjects (18 eyes) underwent FLEx and 23 subjects (23 eyes) underwent SMILE in this single-center and prospective study. Central corneal sensitivity, Schirmer I test (SIT), noninvasive tear breakup time (NI-TBUT), tear meniscus height, corneal fluorescein (FL) staining, and ocular surface disease index (OSDI) were assessed in all patients. Concentrations of interleukin-1α (IL-1α), tumor necrosis factor-α (TNF-α), nerve growth factor (NGF), interferon-γ (IFN-γ), transforming growth factor-β1 (TGF-β1) and matrix metalloproteinase-9 (MMP-9) in collected tears were measured by multiplex antibody microarray.
Results
Central corneal sensitivity was reduced in both groups, but the scores in the SMILE group were higher than those in the FLEx group at all time points postoperatively (P<0.01). Lower FL scores and longer NI-BUT were observed in the SMILE group 1 week after surgery (P<0.05). OSDI scores in both groups increased rapidly at 1 day and 1 week postoperatively, then returned to their preoperative levels within 1 month (P<0.05). There were no significant differences in SIT or tear meniscus height between the two groups. Lower and faster recovery of tear NGF, TGF-β1 and IL-1α concentration were found in the SMILE group compared to the FLEx group postoperatively. No significant difference was found in tear TNF-α, IFN-γ and MMP-9 for either group before or after surgery. Tear NGF, TGF-β1 and IL-1α show a correlation with ocular surface changes after FLEx or SMILE surgery.
Conclusion
SMILE has superiority over FLEx in early ocular surface changes and NGF, TGF-β1 and IL-1α may contribute to the process of ocular surface recovery.
Trial Registration
ClinicalTrials.gov NCT02540785 To evaluate the short-term changes in ocular surface measures and tear inflammatory mediators after femtosecond lenticule extraction (FLEx) and small-incision lenticule extraction (SMILE) procedures.PURPOSETo evaluate the short-term changes in ocular surface measures and tear inflammatory mediators after femtosecond lenticule extraction (FLEx) and small-incision lenticule extraction (SMILE) procedures.Eighteen subjects (18 eyes) underwent FLEx and 23 subjects (23 eyes) underwent SMILE in this single-center and prospective study. Central corneal sensitivity, Schirmer I test (SIT), noninvasive tear breakup time (NI-TBUT), tear meniscus height, corneal fluorescein (FL) staining, and ocular surface disease index (OSDI) were assessed in all patients. Concentrations of interleukin-1α (IL-1α), tumor necrosis factor-α (TNF-α), nerve growth factor (NGF), interferon-γ (IFN-γ), transforming growth factor-β1 (TGF-β1) and matrix metalloproteinase-9 (MMP-9) in collected tears were measured by multiplex antibody microarray.METHODSEighteen subjects (18 eyes) underwent FLEx and 23 subjects (23 eyes) underwent SMILE in this single-center and prospective study. Central corneal sensitivity, Schirmer I test (SIT), noninvasive tear breakup time (NI-TBUT), tear meniscus height, corneal fluorescein (FL) staining, and ocular surface disease index (OSDI) were assessed in all patients. Concentrations of interleukin-1α (IL-1α), tumor necrosis factor-α (TNF-α), nerve growth factor (NGF), interferon-γ (IFN-γ), transforming growth factor-β1 (TGF-β1) and matrix metalloproteinase-9 (MMP-9) in collected tears were measured by multiplex antibody microarray.Central corneal sensitivity was reduced in both groups, but the scores in the SMILE group were higher than those in the FLEx group at all time points postoperatively (P<0.01). Lower FL scores and longer NI-BUT were observed in the SMILE group 1 week after surgery (P<0.05). OSDI scores in both groups increased rapidly at 1 day and 1 week postoperatively, then returned to their preoperative levels within 1 month (P<0.05). There were no significant differences in SIT or tear meniscus height between the two groups. Lower and faster recovery of tear NGF, TGF-β1 and IL-1α concentration were found in the SMILE group compared to the FLEx group postoperatively. No significant difference was found in tear TNF-α, IFN-γ and MMP-9 for either group before or after surgery. Tear NGF, TGF-β1 and IL-1α show a correlation with ocular surface changes after FLEx or SMILE surgery.RESULTSCentral corneal sensitivity was reduced in both groups, but the scores in the SMILE group were higher than those in the FLEx group at all time points postoperatively (P<0.01). Lower FL scores and longer NI-BUT were observed in the SMILE group 1 week after surgery (P<0.05). OSDI scores in both groups increased rapidly at 1 day and 1 week postoperatively, then returned to their preoperative levels within 1 month (P<0.05). There were no significant differences in SIT or tear meniscus height between the two groups. Lower and faster recovery of tear NGF, TGF-β1 and IL-1α concentration were found in the SMILE group compared to the FLEx group postoperatively. No significant difference was found in tear TNF-α, IFN-γ and MMP-9 for either group before or after surgery. Tear NGF, TGF-β1 and IL-1α show a correlation with ocular surface changes after FLEx or SMILE surgery.SMILE has superiority over FLEx in early ocular surface changes and NGF, TGF-β1 and IL-1α may contribute to the process of ocular surface recovery.CONCLUSIONSMILE has superiority over FLEx in early ocular surface changes and NGF, TGF-β1 and IL-1α may contribute to the process of ocular surface recovery.ClinicalTrials.gov NCT02540785.TRIAL REGISTRATIONClinicalTrials.gov NCT02540785. To evaluate the short-term changes in ocular surface measures and tear inflammatory mediators after femtosecond lenticule extraction (FLEx) and small-incision lenticule extraction (SMILE) procedures. Eighteen subjects (18 eyes) underwent FLEx and 23 subjects (23 eyes) underwent SMILE in this single-center and prospective study. Central corneal sensitivity, Schirmer I test (SIT), noninvasive tear breakup time (NI-TBUT), tear meniscus height, corneal fluorescein (FL) staining, and ocular surface disease index (OSDI) were assessed in all patients. Concentrations of interleukin-1α (IL-1α), tumor necrosis factor-α (TNF-α), nerve growth factor (NGF), interferon-γ (IFN-γ), transforming growth factor-β1 (TGF-β1) and matrix metalloproteinase-9 (MMP-9) in collected tears were measured by multiplex antibody microarray. Central corneal sensitivity was reduced in both groups, but the scores in the SMILE group were higher than those in the FLEx group at all time points postoperatively (P<0.01). Lower FL scores and longer NI-BUT were observed in the SMILE group 1 week after surgery (P<0.05). OSDI scores in both groups increased rapidly at 1 day and 1 week postoperatively, then returned to their preoperative levels within 1 month (P<0.05). There were no significant differences in SIT or tear meniscus height between the two groups. Lower and faster recovery of tear NGF, TGF-β1 and IL-1α concentration were found in the SMILE group compared to the FLEx group postoperatively. No significant difference was found in tear TNF-α, IFN-γ and MMP-9 for either group before or after surgery. Tear NGF, TGF-β1 and IL-1α show a correlation with ocular surface changes after FLEx or SMILE surgery. SMILE has superiority over FLEx in early ocular surface changes and NGF, TGF-β1 and IL-1α may contribute to the process of ocular surface recovery. ClinicalTrials.gov NCT02540785. Purpose To evaluate the short-term changes in ocular surface measures and tear inflammatory mediators after femtosecond lenticule extraction (FLEx) and small-incision lenticule extraction (SMILE) procedures. Methods Eighteen subjects (18 eyes) underwent FLEx and 23 subjects (23 eyes) underwent SMILE in this single-center and prospective study. Central corneal sensitivity, Schirmer I test (SIT), noninvasive tear breakup time (NI-TBUT), tear meniscus height, corneal fluorescein (FL) staining, and ocular surface disease index (OSDI) were assessed in all patients. Concentrations of interleukin-1α (IL-1α), tumor necrosis factor-α (TNF-α), nerve growth factor (NGF), interferon-γ (IFN-γ), transforming growth factor-β1 (TGF-β1) and matrix metalloproteinase-9 (MMP-9) in collected tears were measured by multiplex antibody microarray. Results Central corneal sensitivity was reduced in both groups, but the scores in the SMILE group were higher than those in the FLEx group at all time points postoperatively (P<0.01). Lower FL scores and longer NI-BUT were observed in the SMILE group 1 week after surgery (P<0.05). OSDI scores in both groups increased rapidly at 1 day and 1 week postoperatively, then returned to their preoperative levels within 1 month (P<0.05). There were no significant differences in SIT or tear meniscus height between the two groups. Lower and faster recovery of tear NGF, TGF-β1 and IL-1α concentration were found in the SMILE group compared to the FLEx group postoperatively. No significant difference was found in tear TNF-α, IFN-γ and MMP-9 for either group before or after surgery. Tear NGF, TGF-β1 and IL-1α show a correlation with ocular surface changes after FLEx or SMILE surgery. Conclusion SMILE has superiority over FLEx in early ocular surface changes and NGF, TGF-β1 and IL-1α may contribute to the process of ocular surface recovery. Trial Registration ClinicalTrials.gov NCT02540785 PurposeTo evaluate the short-term changes in ocular surface measures and tear inflammatory mediators after femtosecond lenticule extraction (FLEx) and small-incision lenticule extraction (SMILE) procedures.MethodsEighteen subjects (18 eyes) underwent FLEx and 23 subjects (23 eyes) underwent SMILE in this single-center and prospective study. Central corneal sensitivity, Schirmer I test (SIT), noninvasive tear breakup time (NI-TBUT), tear meniscus height, corneal fluorescein (FL) staining, and ocular surface disease index (OSDI) were assessed in all patients. Concentrations of interleukin-1α (IL-1α), tumor necrosis factor-α (TNF-α), nerve growth factor (NGF), interferon-γ (IFN-γ), transforming growth factor-β1 (TGF-β1) and matrix metalloproteinase-9 (MMP-9) in collected tears were measured by multiplex antibody microarray.ResultsCentral corneal sensitivity was reduced in both groups, but the scores in the SMILE group were higher than those in the FLEx group at all time points postoperatively (P<0.01). Lower FL scores and longer NI-BUT were observed in the SMILE group 1 week after surgery (P<0.05). OSDI scores in both groups increased rapidly at 1 day and 1 week postoperatively, then returned to their preoperative levels within 1 month (P<0.05). There were no significant differences in SIT or tear meniscus height between the two groups. Lower and faster recovery of tear NGF, TGF-β1 and IL-1α concentration were found in the SMILE group compared to the FLEx group postoperatively. No significant difference was found in tear TNF-α, IFN-γ and MMP-9 for either group before or after surgery. Tear NGF, TGF-β1 and IL-1α show a correlation with ocular surface changes after FLEx or SMILE surgery.ConclusionSMILE has superiority over FLEx in early ocular surface changes and NGF, TGF-β1 and IL-1α may contribute to the process of ocular surface recovery.Trial registrationClinicalTrials.gov NCT02540785. |
| Author | Liu, Liangping Li, Gang Niu, Bing Zhang, Chi Zhong, Xingwu He, Miao Liu, Lina Ding, Hui |
| AuthorAffiliation | 1 Zhongshan Ophthalmic Center and State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou 510060, China 2 Department of Ophthalmology, The First People’s Hospital of Foshan, Foshan 528000, China 3 Hainan Eye Hospital, Zhongshan Ophthalmic Center, Sun Yat-sen University, Haikou 570311, China The Chinese University of Hong Kong, HONG KONG 5 Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, United States of America 4 Shanghai Key Laboratory of Bio-energy Crops, School of Life Science, Shanghai University, Shanghai 200444, China |
| AuthorAffiliation_xml | – name: The Chinese University of Hong Kong, HONG KONG – name: 5 Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, United States of America – name: 1 Zhongshan Ophthalmic Center and State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou 510060, China – name: 3 Hainan Eye Hospital, Zhongshan Ophthalmic Center, Sun Yat-sen University, Haikou 570311, China – name: 4 Shanghai Key Laboratory of Bio-energy Crops, School of Life Science, Shanghai University, Shanghai 200444, China – name: 2 Department of Ophthalmology, The First People’s Hospital of Foshan, Foshan 528000, China |
| Author_xml | – sequence: 1 givenname: Chi surname: Zhang fullname: Zhang, Chi – sequence: 2 givenname: Hui surname: Ding fullname: Ding, Hui – sequence: 3 givenname: Miao surname: He fullname: He, Miao – sequence: 4 givenname: Lina surname: Liu fullname: Liu, Lina – sequence: 5 givenname: Liangping surname: Liu fullname: Liu, Liangping – sequence: 6 givenname: Gang surname: Li fullname: Li, Gang – sequence: 7 givenname: Bing surname: Niu fullname: Niu, Bing – sequence: 8 givenname: Xingwu surname: Zhong fullname: Zhong, Xingwu |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26937680$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9ks9uGyEQxldVquZP-wZVi9RLL3ZZYIHtIVJlOa0lVzkkd4TZWQeLBRd22_hR8rZlaydKoqgSEmj45jffwJwWRz54KIr3JZ6WVJRfNmGIXrvpNoenuGR1hemr4qSsKZlwgunRo_NxcZrSBuOKSs7fFMeE11RwiU-Ku1notjraFDwKLZrr6HZodqP9GhKyHl2awemIrobYagNI-wYtfOt01-k-xB36CY0dTwmtoP8D4NEFdH1IYEKWLsH3NhMAzW_7qE1vc5mRcdVp5yYLb2waQy_p3havW-0SvDvsZ8X1xfx69mOyvPy-mH1bTkxFeD-pcSsISMYwVJrhesUBSxC0FlVNqMSEAW0ZFrXJS2pjqoqxCjPSctY2K3pWfNxjty4kdXjUpEohMCGcUJ4Vi72iCXqjttF2Ou5U0Fb9C4S4Vjpm-w4UNE1JBBZYtmWuIiWsNNSVFDVuSCVNZp0fqg2rDhqT-47aPYE-vfH2Rq3Db8WEEJSLDPh8AMTwa4DUq84mA85pD2HY-5aCMjL6_vRM-nJ3Hx47erByPyJZwPYCE0NKEdoHSYnVOIn3WDVOojpMYk77-izN2F6PH5v7su7_yX8B4mPpeQ |
| CitedBy_id | crossref_primary_10_3928_1081597X_20250305_01 crossref_primary_10_1186_s12886_024_03414_9 crossref_primary_10_1007_s10792_017_0717_x crossref_primary_10_1155_2022_9774448 crossref_primary_10_3390_ijms25010366 crossref_primary_10_1016_j_ajo_2017_05_005 crossref_primary_10_12968_opti_2017_3_152186 crossref_primary_10_3390_biom12101470 crossref_primary_10_3928_1081597X_20230814_02 crossref_primary_10_3389_fmed_2021_731462 crossref_primary_10_1097_MD_0000000000013586 crossref_primary_10_1167_iovs_17_23538 crossref_primary_10_4103_ijo_IJO_1957_20 crossref_primary_10_1167_iovs_61_5_55 crossref_primary_10_1016_j_clae_2017_10_009 crossref_primary_10_1186_s12886_017_0595_z crossref_primary_10_4103_1673_5374_247421 crossref_primary_10_3390_diagnostics11081326 crossref_primary_10_4103_1673_5374_308666 |
| Cites_doi | 10.1001/archophthalmol.2011.364 10.1097/IIO.0b013e31819242c9 10.3928/1081597X-20140120-05 10.1016/j.cytogfr.2004.09.003 10.3928/1081597X-20120815-01 10.1001/archopht.116.11.1470 10.1016/S0014-4835(03)00050-2 10.3109/08820538.2014.962663 10.1155/2014/265012 10.1097/ICO.0b013e3182714425 10.1007/s00417-013-2272-0 10.1097/01.ico.0000178743.06340.2c 10.1056/NEJM199804233381702 10.1111/j.1755-3768.1989.tb07098.x 10.1097/00003226-199707000-00015 10.2147/OPTH.S11924 10.1016/j.jcrs.2009.05.032 10.1167/iovs.11-7439 10.1371/journal.pone.0107370 10.1097/ICO.0b013e3181a2a7e3 10.1076/ceyr.16.6.605.5081 10.1167/iovs.11-8708 10.1016/j.ophtha.2014.10.004 10.1097/01.ico.0000133997.07144.9e 10.1111/j.1749-6632.1992.tb39751.x 10.1167/iovs.12-10816 10.1007/978-1-4615-5359-5_72 10.1016/j.jcrs.2007.08.028 10.1016/j.jcrs.2004.09.044 10.1167/iovs.07-0069 10.3928/1081597X-20080401-14 10.1136/bjo.81.2.145 10.1016/S1542-0124(12)70082-4 10.3928/1081-597X-20070901-05 10.1080/02713689808951242 10.1016/j.ajo.2004.08.039 10.2147/OPTH.S12381 10.3928/1081597X-20141218-01 10.1073/pnas.85.13.4894 10.3928/1081597X-20121115-01 10.3928/1081597X-20120815-07 10.1111/j.1755-3768.2012.02406.x 10.1167/iovs.03-1145 10.1016/j.jcrs.2008.05.033 10.1006/exer.1996.0038 10.1016/S0021-9258(17)35666-1 10.1371/journal.pone.0113774 10.1016/j.ajo.2004.12.051 10.1016/j.jcrs.2008.10.030 10.1006/exer.1994.1081 10.1016/S0161-6420(01)00623-6 10.1136/bjo.2009.174284 |
| ContentType | Journal Article |
| Copyright | 2016 Zhang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2016 Zhang et al 2016 Zhang et al |
| Copyright_xml | – notice: 2016 Zhang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2016 Zhang et al 2016 Zhang et al |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QG 7QL 7QO 7RV 7SN 7SS 7T5 7TG 7TM 7U9 7X2 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M7N M7P M7S NAPCQ P5Z P62 P64 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PTHSS PYCSY RC3 7X8 5PM DOA |
| DOI | 10.1371/journal.pone.0149503 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts Nursing & Allied Health Database Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Meteorological & Geoastrophysical Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Computer Science Collection Agricultural & Environmental Science Collection ProQuest Central Essentials - QC Biological Science Collection ProQuest Central (New) ProQuest Technology Collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One ProQuest Materials Science Collection ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Collection (ProQuest) ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection ProQuest Biological Science Collection Agriculture Science Database ProQuest Health & Medical Collection Medical Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database (ProQuest) Engineering Database Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Materials Science Collection Proquest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China Engineering Collection Environmental Science Collection Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database Publicly Available Content Database ProQuest Central Student ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Materials Science Collection ProQuest Public Health ProQuest Nursing & Allied Health Source ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE Agricultural Science Database |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Sciences (General) |
| DocumentTitleAlternate | Early Changes between FLEx and SMILE |
| EISSN | 1932-6203 |
| ExternalDocumentID | 1770226236 oai_doaj_org_article_edd1270708f144588ebae958790d258c PMC4777367 3970747901 26937680 10_1371_journal_pone_0149503 |
| Genre | Clinical Trial Research Support, Non-U.S. Gov't Journal Article |
| GeographicLocations | United States--US China |
| GeographicLocations_xml | – name: China – name: United States--US |
| GroupedDBID | --- 123 29O 2WC 53G 5VS 7RV 7X2 7X7 7XC 88E 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ AAUCC AAWOE AAYXX ABDBF ABIVO ABJCF ABUWG ACCTH ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV ADRAZ AEAQA AENEX AEUYN AFFHD AFKRA AFPKN AFRAH AHMBA ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ARAPS ATCPS BAIFH BAWUL BBNVY BBTPI BCNDV BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI BWKFM CCPQU CITATION CS3 D1I D1J D1K DIK DU5 E3Z EAP EAS EBD EMOBN ESX EX3 F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IEA IGS IHR IHW INH INR IOV IPY ISE ISR ITC K6- KB. KQ8 L6V LK5 LK8 M0K M1P M48 M7P M7R M7S M~E NAPCQ O5R O5S OK1 OVT P2P P62 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PTHSS PV9 PYCSY RNS RPM RZL SV3 TR2 UKHRP WOQ WOW ~02 ~KM 3V. ALIPV BBORY CGR CUY CVF ECM EIF IPNFZ NPM RIG 7QG 7QL 7QO 7SN 7SS 7T5 7TG 7TM 7U9 7XB 8FD 8FK AZQEC C1K DWQXO ESTFP FR3 GNUQQ H94 K9. KL. M7N P64 PKEHL PQEST PQUKI PRINS RC3 7X8 PUEGO 5PM AAPBV ABPTK BBAFP N95 |
| ID | FETCH-LOGICAL-c526t-90f72e8440e5a409b6e08e739759238024e3f4079c79c8acc55445042f64fdb3 |
| IEDL.DBID | DOA |
| ISICitedReferencesCount | 23 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000371735200026&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1932-6203 |
| IngestDate | Sun Jan 01 07:45:44 EST 2023 Tue Oct 14 18:25:29 EDT 2025 Tue Nov 04 01:50:40 EST 2025 Fri Sep 05 10:09:39 EDT 2025 Tue Oct 07 07:14:36 EDT 2025 Wed Feb 19 02:33:54 EST 2025 Tue Nov 18 21:00:22 EST 2025 Sat Nov 29 03:28:18 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Language | English |
| License | This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Creative Commons Attribution License |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c526t-90f72e8440e5a409b6e08e739759238024e3f4079c79c8acc55445042f64fdb3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23 Competing Interests: The authors have declared that no competing interests exist. Conceived and designed the experiments: XZ CZ. Performed the experiments: CZ HD MH Lina Liu GL Liangping Liu BN XZ. Analyzed the data: CZ GL. Contributed reagents/materials/analysis tools: CZ XZ. Wrote the paper: CZ XZ. |
| OpenAccessLink | https://doaj.org/article/edd1270708f144588ebae958790d258c |
| PMID | 26937680 |
| PQID | 1770226236 |
| PQPubID | 1436336 |
| ParticipantIDs | plos_journals_1770226236 doaj_primary_oai_doaj_org_article_edd1270708f144588ebae958790d258c pubmedcentral_primary_oai_pubmedcentral_nih_gov_4777367 proquest_miscellaneous_1770873426 proquest_journals_1770226236 pubmed_primary_26937680 crossref_primary_10_1371_journal_pone_0149503 crossref_citationtrail_10_1371_journal_pone_0149503 |
| PublicationCentury | 2000 |
| PublicationDate | 2016-03-03 |
| PublicationDateYYYYMMDD | 2016-03-03 |
| PublicationDate_xml | – month: 03 year: 2016 text: 2016-03-03 day: 03 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: San Francisco – name: San Francisco, CA USA |
| PublicationTitle | PloS one |
| PublicationTitleAlternate | PLoS One |
| PublicationYear | 2016 |
| Publisher | Public Library of Science Public Library of Science (PLoS) |
| Publisher_xml | – name: Public Library of Science – name: Public Library of Science (PLoS) |
| References | SE Wilson (ref56) 1996; 62 M Blum (ref2) 2010; 248 FJ Potgieter (ref29) 2005; 31 TR Mosmann (ref65) 1992; 664 A Vestergaard (ref3) 2013; 91 A Solomon (ref57) 2001; 42 A Lambiase (ref52) 1998; 338 M Vesaluoma (ref62) 1997; 81 A Lambiase (ref42) 2000; 41 MI Huh (ref49) 2009; 24 S Ueda (ref24) 1989; 192 JL Andresen (ref48) 1997; 16 A Micera (ref53) 2004; 15 T Mutoh (ref63) 2010; 4 C Albou-Ganem (ref8) 2015; 38 LJ Muller (ref25) 2003; 76 HK Lee (ref38) 2005; 139 W Stevenson (ref18) 2012; 130 ME Fini (ref50) 2005; 24 A Agca (ref67) 2014; 2014 A Labbe (ref30) 2012; 53 LJ Muller (ref23) 1996; 37 R Montesano (ref45) 1988; 85 SE Wilson (ref58) 2001; 20 R Ishii (ref28) 2015; 31 JV Jester (ref47) 1999; 40 AK Riau (ref37) 2011; 52 JC Huang (ref11) 2012; 28 MQ Salomao (ref10) 2009; 35 KK Nichols (ref34) 2004; 23 (ref35) 2007; 5 YC Liu (ref7) 2014; 9 AH Vestergaard (ref19) 2014; 30 MH Dastjerdi (ref27) 2009; 49 MV Netto (ref13) 2007; 23 A Leonardi (ref16) 2009; 35 T Mutoh (ref61) 2010; 4 Y Wu (ref39) 2009; 28 S Gao (ref22) 2014; 9 S Wei (ref5) 2013; 251 W Sekundo (ref1) 2008; 34 RA Ignotz (ref46) 1986; 261 L Battat (ref32) 2001; 108 J Hong (ref33) 2013; 32 L You (ref41) 2000; 41 J Weng (ref54) 1997; 16 R Ambrosio Jr. (ref9) 2008; 24 R Nejima (ref12) 2005; 139 ME Fini (ref59) 1990; 31 M Vesaluoma (ref15) 1998; 438 Y Nakamura (ref14) 1998; 17 A Touhami (ref40) 2002; 43 Y Okada (ref64) 2007; 13 TP O'Brien (ref36) 1998; 116 Y Zhang (ref17) 2012; 28 BA Levinson (ref31) 2008; 34 SE Wilson (ref55) 1994; 59 L Luo (ref60) 2004; 45 A Denoyer (ref21) 2015; 122 FE Kruse (ref43) 1993; 34 JO Hjortdal (ref6) 2012; 28 W Sekundo (ref4) 2011; 95 D Raoof (ref26) 2014; 29 CS De Paiva (ref66) 2007; 48 T Blanco-Mezquita (ref44) 2013; 54 YK Ji Z (ref51) 1994; 35 AH Vestergaard (ref20) 2013; 251 |
| References_xml | – volume: 130 start-page: 90 year: 2012 ident: ref18 article-title: Dry eye disease: an immune-mediated ocular surface disorder publication-title: Arch Ophthalmol doi: 10.1001/archophthalmol.2011.364 – volume: 34 start-page: 1963 year: 1993 ident: ref43 article-title: Growth factors modulate clonal growth and differentiation of cultured rabbit limbal and corneal epithelium publication-title: Invest Ophthalmol Vis Sci – volume: 248 start-page: 1019 year: 2010 ident: ref2 article-title: Femtosecond lenticule extraction for the correction of myopia: preliminary 6-month results. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle publication-title: Ophthalmologie – volume: 37 start-page: 476 year: 1996 ident: ref23 article-title: Ultrastructural organization of human corneal nerves publication-title: Invest Ophthalmol Vis Sci – volume: 49 start-page: 11 year: 2009 ident: ref27 article-title: Corneal nerve alterations in dry eye-associated ocular surface disease publication-title: Int Ophthalmol Clin doi: 10.1097/IIO.0b013e31819242c9 – volume: 13 start-page: 1428 year: 2007 ident: ref64 article-title: TNFalpha suppression of corneal epithelium migration publication-title: Mol Vis – volume: 30 start-page: 102 year: 2014 ident: ref19 article-title: Central corneal sublayer pachymetry and biomechanical properties after refractive femtosecond lenticule extraction publication-title: Journal of refractive surgery doi: 10.3928/1081597X-20140120-05 – volume: 15 start-page: 411 year: 2004 ident: ref53 article-title: Nerve growth factor involvement in the visual system: implications in allergic and neurodegenerative diseases publication-title: Cytokine Growth Factor Rev doi: 10.1016/j.cytogfr.2004.09.003 – volume: 28 start-page: 632 year: 2012 ident: ref17 article-title: Comparison of Tear cytokines and clinical outcomes between off-flap and on-flap epi-LASIK with mitomycin C publication-title: Journal of refractive surgery doi: 10.3928/1081597X-20120815-01 – volume: 251 start-page: 2591 year: 2013 ident: ref20 article-title: Subbasal nerve morphology, corneal sensation, and tear film evaluation after refractive femtosecond laser lenticule extraction. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle publication-title: Ophthalmologie – volume: 116 start-page: 1470 year: 1998 ident: ref36 article-title: Inflammatory response in the early stages of wound healing after excimer laser keratectomy publication-title: Arch Ophthalmol doi: 10.1001/archopht.116.11.1470 – volume: 76 start-page: 521 year: 2003 ident: ref25 article-title: Corneal nerves: structure, contents and function publication-title: Exp Eye Res doi: 10.1016/S0014-4835(03)00050-2 – volume: 29 start-page: 358 year: 2014 ident: ref26 article-title: Dry eye after laser in-situ keratomileusis publication-title: Semin Ophthalmol doi: 10.3109/08820538.2014.962663 – volume: 2014 start-page: 265012 year: 2014 ident: ref67 article-title: Corneal backscatter analysis by in vivo confocal microscopy: fellow eye comparison of small incision lenticule extraction and femtosecond laser-assisted LASIK publication-title: Journal of ophthalmology doi: 10.1155/2014/265012 – volume: 32 start-page: 716 year: 2013 ident: ref33 article-title: Assessment of tear film stability in dry eye with a newly developed keratograph publication-title: Cornea doi: 10.1097/ICO.0b013e3182714425 – volume: 251 start-page: 1645 year: 2013 ident: ref5 article-title: Comparison of corneal sensitivity between FS-LASIK and femtosecond lenticule extraction (ReLEx flex) or small-incision lenticule extraction (ReLEx smile) for myopic eyes publication-title: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie doi: 10.1007/s00417-013-2272-0 – volume: 24 start-page: S2 year: 2005 ident: ref50 article-title: How the cornea heals: cornea-specific repair mechanisms affecting surgical outcomes publication-title: Cornea doi: 10.1097/01.ico.0000178743.06340.2c – volume: 338 start-page: 1174 year: 1998 ident: ref52 article-title: Topical treatment with nerve growth factor for corneal neurotrophic ulcers publication-title: N Engl J Med doi: 10.1056/NEJM199804233381702 – volume: 192 start-page: 80 year: 1989 ident: ref24 article-title: Peptidergic and catecholaminergic fibers in the human corneal epithelium. An immunohistochemical and electron microscopic study publication-title: Acta Ophthalmol Suppl doi: 10.1111/j.1755-3768.1989.tb07098.x – volume: 16 start-page: 465 year: 1997 ident: ref54 article-title: IL-1 upregulates keratinocyte growth factor and hepatocyte growth factor mRNA and protein production by cultured stromal fibroblast cells: interleukin-1 beta expression in the cornea publication-title: Cornea doi: 10.1097/00003226-199707000-00015 – volume: 4 start-page: 823 year: 2010 ident: ref61 article-title: Correlation between the matrix metalloproteinase-9 activity and chondroitin sulfate concentrations in tear fluid after laser in situ keratomileusis publication-title: Clin Ophthalmol doi: 10.2147/OPTH.S11924 – volume: 35 start-page: 1756 year: 2009 ident: ref10 article-title: Dry eye associated with laser in situ keratomileusis: Mechanical microkeratome versus femtosecond laser publication-title: Journal of cataract and refractive surgery doi: 10.1016/j.jcrs.2009.05.032 – volume: 52 start-page: 6213 year: 2011 ident: ref37 article-title: Early corneal wound healing and inflammatory responses after refractive lenticule extraction (ReLEx) publication-title: Invest Ophthalmol Vis Sci doi: 10.1167/iovs.11-7439 – volume: 9 start-page: e107370 year: 2014 ident: ref22 article-title: Early changes in ocular surface and tear inflammatory mediators after small-incision lenticule extraction and femtosecond laser-assisted laser in situ keratomileusis publication-title: PloS one doi: 10.1371/journal.pone.0107370 – volume: 31 start-page: 1779 year: 1990 ident: ref59 article-title: Expression of collagenolytic/gelatinolytic metalloproteinases by normal cornea publication-title: Invest Ophthalmol Vis Sci – volume: 28 start-page: 1144 year: 2009 ident: ref39 article-title: Determination of the nerve growth factor level in the central cornea after LASIK and Epi-LASIK treatment in a rabbit model system publication-title: Cornea doi: 10.1097/ICO.0b013e3181a2a7e3 – volume: 16 start-page: 605 year: 1997 ident: ref48 article-title: Keratocyte migration and peptide growth factors: the effect of PDGF, bFGF, EGF, IGF-I, aFGF and TGF-beta on human keratocyte migration in a collagen gel publication-title: Curr Eye Res doi: 10.1076/ceyr.16.6.605.5081 – volume: 53 start-page: 4926 year: 2012 ident: ref30 article-title: The relationship between subbasal nerve morphology and corneal sensation in ocular surface disease publication-title: Invest Ophthalmol Vis Sci doi: 10.1167/iovs.11-8708 – volume: 41 start-page: 692 year: 2000 ident: ref41 article-title: Neurotrophic factors in the human cornea publication-title: Invest Ophthalmol Vis Sci – volume: 122 start-page: 669 year: 2015 ident: ref21 article-title: Dry eye disease after refractive surgery: comparative outcomes of small incision lenticule extraction versus LASIK publication-title: Ophthalmology doi: 10.1016/j.ophtha.2014.10.004 – volume: 23 start-page: 762 year: 2004 ident: ref34 article-title: The lack of association between signs and symptoms in patients with dry eye disease publication-title: Cornea doi: 10.1097/01.ico.0000133997.07144.9e – volume: 664 start-page: 89 year: 1992 ident: ref65 article-title: T lymphocyte subsets, cytokines, and effector functions publication-title: Ann N Y Acad Sci doi: 10.1111/j.1749-6632.1992.tb39751.x – volume: 54 start-page: 3880 year: 2013 ident: ref44 article-title: Nerve growth factor promotes corneal epithelial migration by enhancing expression of matrix metalloprotease-9 publication-title: Invest Ophthalmol Vis Sci doi: 10.1167/iovs.12-10816 – volume: 38 start-page: 229 year: 2015 ident: ref8 article-title: SMILE: refractive lenticule extraction for myopic correction publication-title: Journal francais d'ophtalmologie – volume: 438 start-page: 515 year: 1998 ident: ref15 article-title: Tear fluid changes after photorefractive keratectomy publication-title: Adv Exp Med Biol doi: 10.1007/978-1-4615-5359-5_72 – volume: 34 start-page: 32 year: 2008 ident: ref31 article-title: Referrals to the Wills Eye Institute Cornea Service after laser in situ keratomileusis: reasons for patient dissatisfaction publication-title: Journal of cataract and refractive surgery doi: 10.1016/j.jcrs.2007.08.028 – volume: 31 start-page: 106 year: 2005 ident: ref29 article-title: Prediction of flap response publication-title: Journal of cataract and refractive surgery doi: 10.1016/j.jcrs.2004.09.044 – volume: 48 start-page: 2553 year: 2007 ident: ref66 article-title: Dry eye-induced conjunctival epithelial squamous metaplasia is modulated by interferon-gamma publication-title: Invest Ophthalmol Vis Sci doi: 10.1167/iovs.07-0069 – volume: 24 start-page: 396 year: 2008 ident: ref9 article-title: LASIK-associated dry eye and neurotrophic epitheliopathy: pathophysiology and strategies for prevention and treatment publication-title: Journal of refractive surgery doi: 10.3928/1081597X-20080401-14 – volume: 81 start-page: 145 year: 1997 ident: ref62 article-title: Increased release of tumour necrosis factor-alpha in human tear fluid after excimer laser induced corneal wound publication-title: The British journal of ophthalmology doi: 10.1136/bjo.81.2.145 – volume: 43 start-page: 987 year: 2002 ident: ref40 article-title: The role of NGF signaling in human limbal epithelium expanded by amniotic membrane culture publication-title: Invest Ophthalmol Vis Sci – volume: 5 start-page: 93 year: 2007 ident: ref35 article-title: The epidemiology of dry eye disease: report of the Epidemiology Subcommittee of the International Dry Eye WorkShop (2007) publication-title: Ocul Surf doi: 10.1016/S1542-0124(12)70082-4 – volume: 23 start-page: 667 year: 2007 ident: ref13 article-title: Femtosecond laser and microkeratome corneal flaps: comparison of stromal wound healing and inflammation publication-title: Journal of refractive surgery doi: 10.3928/1081-597X-20070901-05 – volume: 20 start-page: 625 year: 2001 ident: ref58 article-title: The corneal wound healing response: cytokine-mediated interaction of the epithelium, stroma, and inflammatory cells publication-title: Prog Retin Eye Res – volume: 17 start-page: 673 year: 1998 ident: ref14 article-title: Inflammatory cytokines in normal human tears publication-title: Curr Eye Res doi: 10.1080/02713689808951242 – volume: 139 start-page: 64 year: 2005 ident: ref12 article-title: Corneal barrier function, tear film stability, and corneal sensation after photorefractive keratectomy and laser in situ keratomileusis publication-title: Am J Ophthalmol doi: 10.1016/j.ajo.2004.08.039 – volume: 42 start-page: 2283 year: 2001 ident: ref57 article-title: Pro- and anti-inflammatory forms of interleukin-1 in the tear fluid and conjunctiva of patients with dry-eye disease publication-title: Invest Ophthalmol Vis Sci – volume: 4 start-page: 1015 year: 2010 ident: ref63 article-title: Photorefractive keratectomy: measuring the matrix metalloproteinase activity and chondroitin sulfate concentration in tear fluid publication-title: Clin Ophthalmol doi: 10.2147/OPTH.S12381 – volume: 31 start-page: 10 year: 2015 ident: ref28 article-title: Influence of femtosecond lenticule extraction and small incision lenticule extraction on corneal nerve density and ocular surface: a 1-year prospective, confocal, microscopic study publication-title: Journal of refractive surgery doi: 10.3928/1081597X-20141218-01 – volume: 85 start-page: 4894 year: 1988 ident: ref45 article-title: Transforming growth factor beta stimulates collagen-matrix contraction by fibroblasts: implications for wound healing publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.85.13.4894 – volume: 28 start-page: 865 year: 2012 ident: ref6 article-title: Predictors for the outcome of small-incision lenticule extraction for Myopia publication-title: Journal of refractive surgery doi: 10.3928/1081597X-20121115-01 – volume: 28 start-page: 625 year: 2012 ident: ref11 article-title: Effect of hinge position on corneal sensation and dry eye parameters after femtosecond laser-assisted LASIK publication-title: Journal of refractive surgery doi: 10.3928/1081597X-20120815-07 – volume: 91 start-page: 355 year: 2013 ident: ref3 article-title: Femtosecond (FS) laser vision correction procedure for moderate to high myopia: a prospective study of ReLEx((R)) flex and comparison with a retrospective study of FS-laser in situ keratomileusis publication-title: Acta Ophthalmol doi: 10.1111/j.1755-3768.2012.02406.x – volume: 45 start-page: 4293 year: 2004 ident: ref60 article-title: Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surface publication-title: Invest Ophthalmol Vis Sci doi: 10.1167/iovs.03-1145 – volume: 35 start-page: 1792 year: 1994 ident: ref51 article-title: Transforming growth factor β (TGFβ) expression in the human lacrimal gland. (Abstract) publication-title: Invest Ophthalmol Vis Sci – volume: 24 start-page: 1405 year: 2009 ident: ref49 article-title: Temporal and spatial distribution of TGF-beta isoforms and signaling intermediates in corneal regenerative wound repair publication-title: Histol Histopathol – volume: 34 start-page: 1513 year: 2008 ident: ref1 article-title: First efficacy and safety study of femtosecond lenticule extraction for the correction of myopia: six-month results publication-title: Journal of cataract and refractive surgery doi: 10.1016/j.jcrs.2008.05.033 – volume: 62 start-page: 325 year: 1996 ident: ref56 article-title: Epithelial injury induces keratocyte apoptosis: hypothesized role for the interleukin-1 system in the modulation of corneal tissue organization and wound healing publication-title: Exp Eye Res doi: 10.1006/exer.1996.0038 – volume: 261 start-page: 4337 year: 1986 ident: ref46 article-title: Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix publication-title: J Biol Chem doi: 10.1016/S0021-9258(17)35666-1 – volume: 40 start-page: 1959 year: 1999 ident: ref47 article-title: Transforming growth factor(beta)-mediated corneal myofibroblast differentiation requires actin and fibronectin assembly publication-title: Invest Ophthalmol Vis Sci – volume: 9 start-page: e113774 year: 2014 ident: ref7 article-title: New instruments for lenticule extraction in small incision lenticule extraction (SMILE) publication-title: PloS one doi: 10.1371/journal.pone.0113774 – volume: 139 start-page: 965 year: 2005 ident: ref38 article-title: Nerve growth factor concentration and implications in photorefractive keratectomy vs laser in situ keratomileusis publication-title: Am J Ophthalmol doi: 10.1016/j.ajo.2004.12.051 – volume: 35 start-page: 240 year: 2009 ident: ref16 article-title: Cytokine and chemokine levels in tears and in corneal fibroblast cultures before and after excimer laser treatment publication-title: Journal of cataract and refractive surgery doi: 10.1016/j.jcrs.2008.10.030 – volume: 59 start-page: 63 year: 1994 ident: ref55 article-title: Epidermal growth factor, transforming growth factor alpha, transforming growth factor beta, acidic fibroblast growth factor, basic fibroblast growth factor, and interleukin-1 proteins in the cornea publication-title: Exp Eye Res doi: 10.1006/exer.1994.1081 – volume: 108 start-page: 1230 year: 2001 ident: ref32 article-title: Effects of laser in situ keratomileusis on tear production, clearance, and the ocular surface publication-title: Ophthalmology doi: 10.1016/S0161-6420(01)00623-6 – volume: 41 start-page: 1063 year: 2000 ident: ref42 article-title: Nerve growth factor promotes corneal healing: structural, biochemical, and molecular analyses of rat and human corneas publication-title: Invest Ophthalmol Vis Sci – volume: 95 start-page: 335 year: 2011 ident: ref4 article-title: Small incision corneal refractive surgery using the small incision lenticule extraction (SMILE) procedure for the correction of myopia and myopic astigmatism: results of a 6 month prospective study publication-title: The British journal of ophthalmology doi: 10.1136/bjo.2009.174284 |
| SSID | ssj0053866 |
| Score | 2.3298218 |
| Snippet | To evaluate the short-term changes in ocular surface measures and tear inflammatory mediators after femtosecond lenticule extraction (FLEx) and small-incision... Purpose To evaluate the short-term changes in ocular surface measures and tear inflammatory mediators after femtosecond lenticule extraction (FLEx) and... PurposeTo evaluate the short-term changes in ocular surface measures and tear inflammatory mediators after femtosecond lenticule extraction (FLEx) and... Purpose To evaluate the short-term changes in ocular surface measures and tear inflammatory mediators after femtosecond lenticule extraction (FLEx) and... |
| SourceID | plos doaj pubmedcentral proquest pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | e0149503 |
| SubjectTerms | Adult Antibody microarrays Apoptosis Biology and Life Sciences Chondroitin sulfate Cornea Cornea - metabolism Cornea - pathology Cornea - surgery Corneal Surgery, Laser Cytokines Disease Epithelium, Corneal - pathology Epithelium, Corneal - surgery Eye (anatomy) Female Fibroblasts Fluorescein Gelatinase B Growth factors Hospitals Humans Hypotheses Inflammation Inflammation - metabolism Inflammation - pathology Inflammation - surgery Interferon Interferon-gamma - biosynthesis Interferon-gamma - metabolism Interleukin Interleukin-1alpha - biosynthesis Interleukin-1alpha - metabolism Interleukins Laboratories Lasers Male Matrix metalloproteinase Matrix Metalloproteinase 9 - biosynthesis Matrix Metalloproteinase 9 - metabolism Medicine and Health Sciences Meniscus Metalloproteinase Microscopy Middle Aged Multiplexing Myopia - metabolism Myopia - pathology Myopia - surgery Nerve growth factor Physical Sciences Recovery Refractive Surgical Procedures - methods Sensitivity Social Sciences Surgery Tearing Tears Tears - metabolism Transforming growth factor Transforming growth factor-b1 Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-α Visual Acuity - physiology Wound healing γ-Interferon |
| SummonAdditionalLinks | – databaseName: Nursing & Allied Health Database dbid: 7RV link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Nb9QwELWgcOAClK8GCjISBzi4zaftnBBUXVGpFESrqrfIccaw0m6yJFnEX-HfMnacwKIVHJD2FDvZJH4ev8mM3xDyAklHFiulEbzaMFvjiuWQCxbxXCcigdg4uabLU3F2Jq-u8o_-g1vn0ypHm-gMddVo-438MBIClxtcrPnr1Vdmq0bZ6KovoXGd3IgsN0Y8i0-XoyXGucy53y6XiOjQj87BqqnhwLkGY6ksvxw51X6rcrpoum2M88_Eyd9Wotmd_32Gu-S256D0zQCaXXIN6ntk18_yjr70UtSv7pMfR1OZQtoY6tSQ6bAhoaPzmn5wWaz0fN0apYGquqIntUGQLV3wnr53hUCatqM-H4zOYNk3nfXCK3pqM5XwCkCPv_ftsMPCXeN8qRYLdlIP5X-29ntALmbHF0fvmC_mwHQW857loRExyDQNIVPoVJYcQgkC6VCGHFMiVYDEoHeZa_xJpXVmZYLQpBiemqpMHpKdGsdtj9C0xA5gs2KjEslgJa1GoBZVCgod7pAHJBmHtNBe6NzW21gULnon0OEZ3nNhgVB4IASETWetBqGPf_R_a9Ey9bUy3e5A034u_KwvoKpsZF-E0qDjmkkJpYI8kyIPqziTOiB7FmvjH3TFL4QEZH_E0Pbm51MzGgQb5VE1NOuhjxQJMq-APBrgOt1kzJGNchkGRGwAeeMpNlvq-RcnOp4KIRIuHv_9tp6QW8gouUvSS_bJTt-u4Sm5qb_186595mbnTwvQR5E priority: 102 providerName: ProQuest – databaseName: Public Library of Science (PLoS) Journals Open Access dbid: FPL link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Nb9QwELVQy4ELtHw10FZG4gCHlGyc2M4Rqq6otJRKrVBvkeOMxUq7TpVkEX-Ff8vY8Qa22goh5RRPEnsyk7zRjN8Q8hZBR54qpdF4tYldj6u4gELEE15oJhikxtM1fZuJiwt5c1Nc_gkU72TwmZh8CDo9uW0snHhA78g9d1PGuWvVML2crb-86Luch-1x91258fvxLP2O1XTRdNsQ5t1Cyb_-PNMn_zvnPfI4YEz6cTCKffIA7FOyH7y4o-8C1fT7Z-TX6diGkDaGerZjOmw46Ojc0q--SpVerVqjNFBla3puDRrR0ifn6Rff6KNpOxrqvegUln3TuSi7pjNXiYR3AHr2s2-HHRT-HldLtVjE53Zo77NV7jm5np5dn36OQ7OGWOcp7-MiMSIFmWUJ5AqDxopDIkEg3MkRQ0qEAsAMRo-FxkMqrXNHA4SfDMMzU1fsBdmxqK0DQrMKBcBVvU4qBHu1dByAWtQZKAyoEx4Rtn6FpQ5E5q6fxqL02TmBAc2g59Kpvwzqj0g8XnU7EHn8Q_6Ts45R1tFw-xP4nsvg1SXUtcvci0QaDExzKaFSUORSFEmd5lJH5MDZ1voBXTkRAkETQk5cxeHa3rYPvxmH0eFdFkdZaFaDjBQMkVVEXg7mOU4y5Yg2uUwiIjYMd2MVmyN2_t2TimdCCMbFq_tn_Jo8QrTIfQEeOyQ7fbuCI_JQ_-jnXXvsPfE3Bho1wQ priority: 102 providerName: Public Library of Science |
| Title | Comparison of Early Changes in Ocular Surface and Inflammatory Mediators between Femtosecond Lenticule Extraction and Small-Incision Lenticule Extraction |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/26937680 https://www.proquest.com/docview/1770226236 https://www.proquest.com/docview/1770873426 https://pubmed.ncbi.nlm.nih.gov/PMC4777367 https://doaj.org/article/edd1270708f144588ebae958790d258c http://dx.doi.org/10.1371/journal.pone.0149503 |
| Volume | 11 |
| WOSCitedRecordID | wos000371735200026&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: DOA dateStart: 20060101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M~E dateStart: 20060101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Advanced Technologies & Aerospace Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: P5Z dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/hightechjournals providerName: ProQuest – providerCode: PRVPQU databaseName: Agriculture Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M0K dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/agriculturejournals providerName: ProQuest – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7P dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Engineering Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7S dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com providerName: ProQuest – providerCode: PRVPQU databaseName: Environmental Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PATMY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/environmentalscience providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7X7 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Materials Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: KB. dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/materialsscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7RV dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: BENPR dateStart: 20061201 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 8C1 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PIMPY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVATS databaseName: Public Library of Science customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: FPL dateStart: 20060101 isFulltext: true titleUrlDefault: http://www.plos.org/publications/ providerName: Public Library of Science |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lj9MwELZg4cAFsbw2sFRG4gCHdPP0OEdataLatkTb1apwiVLH0VZqk1XTIv4K_5bxI9UWVdoLUjSHePKwPba_kcffEPIJQUcc5LlA4xWlq3JcuYlMwPVZIkIIZVBquqabMUynfD5P0nupvlRMmKEHNg13IYtCbY6Cx0vE_jHncpHLJOaQeEUQc6FmXw-S1pkyczCOYsbsQbkQ_AvbL927upJd7RS0SbLsQqT5-hW_6apujmHNf0Mm761BwxfkuQWP9Kv56VPySFYvyakdng39bDmkv7wif_r7_IK0LqmmMabmJEFDlxX9rsNP6Wy3KXMhaV4VdFSVaB1rvetOJzqDR71pqA3kokO53taNcp8LOlYhRvgGSQe_txtzNEK_Y7bOVyt3VJm8PUf1XpPr4eC6_821WRhcEQds6yZeCYHkUeTJOEdvcMGkxyUgjokRHHJc42VYoluYCLx4LkSs-H1wLihZVBaL8A05qbDZzwiNFqggVTirv0AUV3BF7iegiGSOnrLHHBK2PZIJy1CuEmWsMr3tBuipmHbOVD9mth8d4u6fujMMHQ_o91Rn73UVv7a-gVaXWavLHrI6h5wpU2k_0GQ-AKIhxJJYi_PWfI4Xf9wX40hW2zN5Jeud0eEQImRyyFtjbfufDBjCSMY9h8CBHR7U4rCkWt5qtvAIAEIG7_5Htd-TZwgYmY7BC8_JyXazkx_IU_Fru2w2HfIYrm6UnIOWHCXv-x3ypDeYplcdPURRDtMxysteF-XEu1QSUi1nKNP4Jz6Rjibpj79TV0WJ |
| linkProvider | Directory of Open Access Journals |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3dbtMwFD4aAwlugAFjgQFGAgkusqVxYjsXCEFZtWpdQVqFdhcljgOV2qQkLT-PwkPwjhw7TqCogqtdIPUqPnUT9zt_8fH5AJ5g0BH6SSIRvDJ3NceVG6mIuz0WScqp8nPTrun9iI_H4vw8ercFP9qzMLqssrWJxlBnpdTvyA97nKO7QWfNXi4-uZo1Su-uthQaDSxO1LcvmLLVL4Zv8P996vuDo0n_2LWsAq4MfbZ0Iy_nvhJB4KkwwewmZcoTiqNfDjHYEeizFM0xzYkkfkQiZaj71SC2cxbkWUpx2ktwOaA-1Uok-l1FCZoOxuzpPMp7hxYMB4uyUAcmE2mZuaz3MyQBuqnqrKw3Bbh_1mn-5vgGN_6zJbsJ122ETV41KrEDW6q4BTvWhtXkmW20_fw2fO93JIykzInp9Uya4xY1mRbkranRJWerKk-kIkmRkWGRowrNTWkCOTU0J2VVE1vtRgZqvixr_Y4hIyNdh4UzKHL0dVk150fMHGfzZDZzh0VDbrRR7g5MLmKFdmG7QJjsAQlSFFC65reXYqibCd0BUfIsUEkPLzIHaIugWNo27ppNZBabvUmO6VyzzrHGXWxx54DbfWvRtDH5h_xrDc5OVjchNxfK6kNsbVqsskzXLXBP5JiWh0KoNFFRKHjkZX4opAN7GtrtD9TxL0A6sN9CdvPw424YzZ3ew0oKVa4aGcEpxpUO3G20o7tJn2GszYTnAF_Tm7WnWB8pph9NS_WAc04Zv_f323oEV48np6N4NByf3IdrGDszU45I92F7Wa3UA7giPy-ndfXQGAYC8QVr1U-tNqAS |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1bb9MwFD4aAyFegAFjgQFGAgkesuZqOw8IwbaKaqVU2oT2FiWODZXapCQtl5_CT-Hfcew4haIKnvaA1Kf41E3c79ziz-cAPMGgIw6yTCB4hXJ1jys3kQlzfZqIkIUyUKZc0_shG434-Xky3oIf3VkYTavsbKIx1EUl9Dvyns8Yuht01rSnLC1ifNR_Of_k6g5Seqe1a6fRQuREfvuC6VvzYnCE__XTIOgfnx2-cW2HAVfEAV24iadYIHkUeTLOMNPJqfS4ZOijYwx8OPovGSpMeRKBH54JEevaNYhzRSNV5CFOewkus4h6gWENjjsngGaEUntSL2R-zwLjYF6V8sBkJV2XLusJTcMAXWB1WjWbgt0_OZu_OcH-jf94-W7CdRt5k1etquzAlixvwY61bQ15ZgtwP78N3w9XzRlJpYipAU3aYxgNmZTkneHuktNlrTIhSVYWZFAqVK2ZoSyQt6b9SVU3xLLgSF_OFlWj3z0UZKj5WTiDJMdfF3V7rsTMcTrLplN3ULZNjzbK3YGzi1ihXdguETJ7QKIcBaTmAvs5hsAF15URBSsimfl4kToQdmhKhS3vrruMTFOzZ8kwzWvXOdUYTC0GHXBX35q35U3-If9aA3Ulq4uTmwtV_SG1ti6VRaH5DMzjCtP1mHOZZzKJOUu8Ioi5cGBPw7z7gSb9BU4H9jv4bh5-vBpGM6j3trJSVstWhrMQ400H7raasrrJgGIMTrnnAFvTobWnWB8pJx9NqfWIMRZSdu_vt_UIrqIypcPB6OQ-XMOQmhqWYrgP24t6KR_AFfF5MWnqh8ZGEEgvWKl-AiqCqR4 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Comparison+of+Early+Changes+in+Ocular+Surface+and+Inflammatory+Mediators+between+Femtosecond+Lenticule+Extraction+and+Small-Incision+Lenticule+Extraction&rft.jtitle=PloS+one&rft.au=Zhang%2C+Chi&rft.au=Ding%2C+Hui&rft.au=He%2C+Miao&rft.au=Liu%2C+Lina&rft.date=2016-03-03&rft.issn=1932-6203&rft.eissn=1932-6203&rft.volume=11&rft.issue=3&rft.spage=e0149503&rft_id=info:doi/10.1371%2Fjournal.pone.0149503&rft.externalDBID=n%2Fa&rft.externalDocID=10_1371_journal_pone_0149503 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon |