Early nurture epigenetically tunes the oxytocin receptor

•4 CpG sites in the Oxtr promoter region are homologous in humans and prairie voles.•Low levels of early parenting lead to high Oxtr DNA methylation in brain and blood.•High Oxtr methylation is associated with low Oxtr gene expression.•Low levels of early care lead to low OXTR density, likely via hi...

Full description

Saved in:

Bibliographic Details
Published in:	Psychoneuroendocrinology Vol. 99; pp. 128 - 136
Main Authors:	Perkeybile, Allison M., Carter, C. Sue, Wroblewski, Kelly L., Puglia, Meghan H., Kenkel, William M., Lillard, Travis S., Karaoli, Themistoclis, Gregory, Simon G., Mohammadi, Niaz, Epstein, Larissa, Bales, Karen L., Connelly, Jessica J.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.01.2019
Subjects:	Animals Arvicolinae Brain - metabolism CpG Islands - genetics DNA methylation DNA Methylation - genetics Female Male Maternal Behavior - physiology Maternal Behavior - psychology Mothers - psychology Nucleus Accumbens - metabolism OXTR Oxytocin Oxytocin - metabolism Pair Bond Prairie vole Promoter Regions, Genetic - genetics Receptors, Oxytocin - genetics Receptors, Oxytocin - physiology Social Behavior DNA methylation OXTR Social behavior Oxytocin Prairie vole
ISSN:	0306-4530, 1873-3360, 1873-3360
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!