Early nurture epigenetically tunes the oxytocin receptor

•4 CpG sites in the Oxtr promoter region are homologous in humans and prairie voles.•Low levels of early parenting lead to high Oxtr DNA methylation in brain and blood.•High Oxtr methylation is associated with low Oxtr gene expression.•Low levels of early care lead to low OXTR density, likely via hi...

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Veröffentlicht in:	Psychoneuroendocrinology Jg. 99; S. 128 - 136
Hauptverfasser:	Perkeybile, Allison M., Carter, C. Sue, Wroblewski, Kelly L., Puglia, Meghan H., Kenkel, William M., Lillard, Travis S., Karaoli, Themistoclis, Gregory, Simon G., Mohammadi, Niaz, Epstein, Larissa, Bales, Karen L., Connelly, Jessica J.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Elsevier Ltd 01.01.2019
Schlagworte:	Animals Arvicolinae Brain - metabolism CpG Islands - genetics DNA methylation DNA Methylation - genetics Female Male Maternal Behavior - physiology Maternal Behavior - psychology Mothers - psychology Nucleus Accumbens - metabolism OXTR Oxytocin Oxytocin - metabolism Pair Bond Prairie vole Promoter Regions, Genetic - genetics Receptors, Oxytocin - genetics Receptors, Oxytocin - physiology Social Behavior DNA methylation OXTR Social behavior Oxytocin Prairie vole
ISSN:	0306-4530, 1873-3360, 1873-3360
Online-Zugang:	Volltext
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