Eliciting priors and relaxing the single causal variant assumption in colocalisation analyses

Horizontal integration of summary statistics from different GWAS traits can be used to evaluate evidence for their shared genetic causality. One popular method to do this is a Bayesian method, coloc, which is attractive in requiring only GWAS summary statistics and no linkage disequilibrium estimate...

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Bibliographic Details
Published in:	PLoS genetics Vol. 16; no. 4; p. e1008720
Main Author:	Wallace, Chris
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.04.2020 Public Library of Science (PLoS)
Subjects:	Bayesian analysis Biology and Life Sciences Causality Computer programs Genome-Wide Association Study - methods Genome-Wide Association Study - standards Genomes Humans Hypotheses Linkage Disequilibrium Medicine and Health Sciences Polymorphism, Single Nucleotide Quantitative Trait Loci Research and Analysis Methods Sensitivity analysis Software Statistical analysis
ISSN:	1553-7404, 1553-7390, 1553-7404
Online Access:	Get full text
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