The MITF-SOX10 regulated long non-coding RNA DIRC3 is a melanoma tumour suppressor

The MITF and SOX10 transcription factors regulate the expression of genes important for melanoma proliferation, invasion and metastasis. Despite growing evidence of the contribution of long noncoding RNAs (lncRNAs) in cancer, including melanoma, their functions within MITF-SOX10 transcriptional prog...

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Veröffentlicht in:	PLoS genetics Jg. 15; H. 12; S. e1008501
Hauptverfasser:	Coe, Elizabeth A., Tan, Jennifer Y., Shapiro, Michael, Louphrasitthiphol, Pakavarin, Bassett, Andrew R., Marques, Ana C., Goding, Colin R., Vance, Keith W.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 01.12.2019 Public Library of Science (PLoS)
Schlagworte:	Binding sites Biochemistry Biology Biology and life sciences Cancer Cell adhesion & migration Cell cycle Cell Line, Tumor Cell Nucleus - genetics Cell Proliferation Chromatin Down-Regulation Funding Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene loci Genomes Humans Insulin-Like Growth Factor Binding Protein 5 - genetics Insulin-like growth factor-binding protein 5 Kidney cancer Medical research Medicine and Health Sciences Melanoma Melanoma - genetics Metastases Microphthalmia-associated transcription factor Microphthalmia-Associated Transcription Factor - genetics Non-coding RNA Prognosis Proteins Regulatory sequences Renal cell carcinoma Research and Analysis Methods RNA polymerase RNA, Long Noncoding - genetics Sequence Analysis, RNA Software Sox10 protein SOXE Transcription Factors - genetics Survival Analysis Therapeutic applications Transcription factors Tumors United Kingdom > UK Switzerland
ISSN:	1553-7404, 1553-7390, 1553-7404
Online-Zugang:	Volltext
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