Nitric Oxide Sustains IL-1β Expression in Human Dendritic Cells Enhancing Their Capacity to Induce IL-17–Producing T-Cells

The role played by lung dendritic cells (DCs) which are influenced by external antigens and by their redox state in controlling inflammation is unclear. We studied the role played by nitric oxide (NO) in DC maturation and function. Human DCs were stimulated with a long-acting NO donor, DPTA NONOate,...

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Bibliographic Details
Published in:	PloS one Vol. 10; no. 4; p. e0120134
Main Authors:	Obregon, Carolina, Graf, Lukas, Chung, Kian Fan, Cesson, Valerie, Nicod, Laurent P.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 08.04.2015 Public Library of Science (PLoS)
Subjects:	Alkenes - pharmacology Antigens Benzoates - pharmacology Cell differentiation Cytokines Dendritic cells Dendritic Cells - drug effects Dendritic Cells - immunology Dendritic Cells - metabolism Differentiation (biology) Dose-Response Relationship, Drug Gene expression Gene Expression Regulation - drug effects Helper cells Humans Imidazoles - pharmacology Inflammation Interleukin 12 Interleukin 17 Interleukin 23 Interleukin 6 Interleukin-17 - biosynthesis Interleukin-17 - metabolism Interleukin-1beta - genetics Lipopolysaccharides Lungs Lymphocytes T Maturation Nitric oxide Nitric Oxide - pharmacology Redox properties T-Lymphocytes - drug effects T-Lymphocytes - immunology T-Lymphocytes - metabolism Time Factors
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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