RORγt and RORα signature genes in human Th17 cells

RORγt and RORα are transcription factors of the RAR-related orphan nuclear receptor (ROR) family. They are expressed in Th17 cells and have been suggested to play a role in Th17 differentiation. Although RORγt signature genes have been characterized in mouse Th17 cells, detailed information on its t...

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Veröffentlicht in:	PloS one Jg. 12; H. 8; S. e0181868
Hauptverfasser:	Castro, Glenda, Liu, Xuejun, Ngo, Karen, De Leon-Tabaldo, Aimee, Zhao, Shanrong, Luna-Roman, Rosa, Yu, Jingxue, Cao, Tinghua, Kuhn, Robert, Wilkinson, Patrick, Herman, Krystal, Nelen, Marina I., Blevitt, Jonathan, Xue, Xiaohua, Fourie, Anne, Fung-Leung, Wai-Ping
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 01.08.2017 Public Library of Science (PLoS)
Schlagworte:	Arthritis Autoimmune diseases Biology and life sciences Biomarkers Biomarkers - metabolism CCL20 protein CCR6 protein CD4 antigen Cell Differentiation Clinical trials Cytokines Differentiation (biology) Gene expression Gene Expression Profiling Gene Expression Regulation Gene sequencing Genes Genes, Reporter Helper cells Humans Inhibitory Concentration 50 Leukocytes, Mononuclear - cytology Ligands Lymphocyte Activation Lymphocytes Lymphocytes T Medical research Medicine and Health Sciences Modulators Nuclear Receptor Subfamily 1, Group F, Member 1 - metabolism Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism Patients Pharmacodynamics Pharmacology Psoriasis Recombinant Proteins - metabolism Research and analysis methods Ribonucleic acid RNA RNA, Small Interfering - metabolism siRNA Skin diseases Th1 Cells - cytology Th17 Cells - metabolism Transcription factors United States > US California
ISSN:	1932-6203, 1932-6203
Online-Zugang:	Volltext
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