Use of the γ-H2AX Assay to Investigate DNA Repair Dynamics Following Multiple Radiation Exposures

Radiation therapy is one of the most common and effective strategies used to treat cancer. The irradiation is usually performed with a fractionated scheme, where the dose required to kill tumour cells is given in several sessions, spaced by specific time intervals, to allow healthy tissue recovery....

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Bibliographic Details
Published in:	PloS one Vol. 8; no. 11; p. e79541
Main Authors:	Mariotti, Luca G., Pirovano, Giacomo, Savage, Kienan I., Ghita, Mihaela, Ottolenghi, Andrea, Prise, Kevin M., Schettino, Giuseppe
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 29.11.2013 Public Library of Science (PLoS)
Subjects:	Apoptosis Biology Cancer Cell cycle Cell Line Cell survival Cell Survival - radiation effects Chromatin Chromatin - radiation effects Deoxyribonucleic acid DNA DNA Damage DNA repair DNA Repair - radiation effects Dose-Response Relationship, Radiation Dynamic tests Exposure Fibroblasts Fibroblasts - metabolism Fibroblasts - radiation effects Histones - metabolism Humans Irradiation Kinases Medical research Oncology Order parameters Phosphatase Phosphorylation Proteins Radiation Radiation Dosage Radiation effects Radiation therapy Radiotherapy - adverse effects Recovery Repair Tumors X-Rays - adverse effects United Kingdom > UK Italy
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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