Lp-PLA2, scavenger receptor class B type I gene (SCARB1) rs10846744 variant, and cardiovascular disease

We previously reported association of SCARB1 SNP rs10846744 with common carotid IMT (cIMT) and cardiovascular disease (CVD) events. Since rs10846744 has been reported in association with Lp-PLA2 mass and activity, we hypothesized that inflammatory pathways might mediate the association of rs10846744...

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Bibliographic Details
Published in:	PloS one Vol. 13; no. 10; p. e0204352
Main Authors:	Manichaikul, Ani, Wang, Xin-Qun, Li, Li, Erdmann, Jeanette, Lettre, Guillaume, Bis, Joshua C., Waterworth, Dawn, Cushman, Mary, Jenny, Nancy S., Post, Wendy S., Palmas, Walter, Tsai, Michael Y., Wallentin, Lars, White, Harvey, Schunkert, Heribert, O’Donnell, Christopher J., Herrington, David M., Rich, Stephen S., O’Donoghue, Michelle L., Rodriguez, Annabelle
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 05.10.2018 Public Library of Science (PLoS)
Subjects:	1-Alkyl-2-acetylglycerophosphocholine Esterase - metabolism Aged Arteriosclerosis Atherosclerosis Biology and Life Sciences Biomarkers - metabolism Cardiology Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - ethnology Cardiovascular Diseases - genetics Cardiovascular Diseases - metabolism Consortia Coronary artery Coronary artery disease Docosahexaenoic acid Eicosapentaenoic acid Fatty acids Female Genetic Predisposition to Disease Genome-Wide Association Study Genomes Genomics Health sciences Heart Heart attacks Heart diseases Homocysteine Humans Infarction Inflammation Inhibitors Laboratories Lipoproteins Lipoproteins (low density) Low density lipoprotein Male Medicine Medicine and Health Sciences Middle Aged Minority & ethnic groups Myocardial infarction Pathology People and places Phospholipase A2 Phospholipids Physical Sciences Polymorphism, Single Nucleotide Public health Research and Analysis Methods Risk analysis Risk Factors Scavenger receptors Scavenger Receptors, Class B - genetics Single-nucleotide polymorphism Stability Stabilization Studies Thrombolysis Canada Montreal Quebec Canada United States > US Germany Quebec Canada
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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