Hypertension-Linked Mutation of α-Adducin Increases CFTR Surface Expression and Activity in HEK and Cultured Rat Distal Convoluted Tubule Cells

The CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) activity and localization are influenced by the cytoskeleton, in particular by actin and its polymerization state. In this study we investigated whether the expression of the hypertensive mutations of α-adducin (G460W-S586C in humans, F3...

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Bibliographic Details
Published in:	PloS one Vol. 7; no. 12; p. e52014
Main Authors:	Mondini, Anna, Sassone, Francesca, Civello, Davide Antonio, Garavaglia, Maria Lisa, Bazzini, Claudia, Rodighiero, Simona, Vezzoli, Valeria, Conti, Fabio, Torielli, Lucia, Capasso, Giovanbattista, Paulmichl, Markus, Meyer, Giuliano
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 21.12.2012 Public Library of Science (PLoS)
Subjects:	Actin Adducin Animals Biology Calmodulin-Binding Proteins - genetics Cell Membrane - metabolism Cells, Cultured Channel gating Chloride Conductance Cystic fibrosis Cystic fibrosis transmembrane conductance regulator Cystic Fibrosis Transmembrane Conductance Regulator - genetics Cystic Fibrosis Transmembrane Conductance Regulator - metabolism Cytoskeleton Data recovery Disease Models, Animal Experiments Fluorescence Fluorescence recovery after photobleaching Forskolin Gene Expression Glycosylation HEK293 Cells Humans Hypertension Hypertension - genetics Hypertension - metabolism Kidney Tubules, Distal - metabolism Life sciences Localization Lymphocytes Lymphocytes T Male Medicine Membrane proteins Membrane turnover Membranes Mutation Patch-Clamp Techniques Phosphorylation Photoactivation Photobleaching Polymerization Protein Binding Proteins Quantum dots Rats Recovery (Medical) Retention Rodents Signal Transduction Transport
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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