Evaluation of the PPAR-γ Agonist Pioglitazone in Mild Asthma: A Double-Blind Randomized Controlled Trial

Peroxisome proliferator-activated receptor gamma (PPAR-γ) is a nuclear receptor that modulates inflammation in models of asthma. To determine whether pioglitazone improves measures of asthma control and airway inflammation, we performed a single-center randomized, double-blind, placebo-controlled, p...

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Bibliographic Details
Published in:	PloS one Vol. 11; no. 8; p. e0160257
Main Authors:	Anderson, J. R., Mortimer, K., Pang, L., Smith, K. M, Bailey, H., Hodgson, D. B., Shaw, D. E., Knox, A. J., Harrison, T. W.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 25.08.2016 Public Library of Science (PLoS)
Subjects:	Adult Aged Airway management Allergies Asthma Asthma - drug therapy Asthma - metabolism Asthma - physiopathology Biology and Life Sciences Bladder Bladder cancer Cancer Chemokine CCL2 - analysis Chemokine CXCL10 - analysis Clinical trials Confidence intervals Control methods Diabetes Double-Blind Method Double-blind studies Drug therapy Eosinophil cationic protein Eosinophil Cationic Protein - analysis Ethics Female Health risks Humans Hypoglycemic Agents - therapeutic use Inflammation Interferon IP-10 protein Male Medicine and Health Sciences Metabolism Middle Aged Monocyte chemoattractant protein 1 Nitric oxide Peroxisome proliferator-activated receptors Physical Sciences Pioglitazone Pneumonia - drug therapy Pneumonia - metabolism Pneumonia - physiopathology PPAR gamma - agonists PPAR gamma - metabolism Quality of Life Randomization Recruitment Research and Analysis Methods Respiratory Function Tests - methods Respiratory tract Respiratory tract diseases Sputum Sputum - metabolism Surveys and Questionnaires Thiazolidinediones - therapeutic use Time Factors Treatment Outcome Tumor necrosis factor-TNF Urinary bladder Vascular endothelial growth factor Vascular Endothelial Growth Factor A - analysis Young Adult
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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