Folic Acid Mitigates Angiotensin-II-Induced Blood Pressure and Renal Remodeling

Clinical data suggests an association between systolic hypertension, renal function and hyperhomocysteinemia (HHcy). HHcy is a state of elevated plasma homocysteine (Hcy) levels and is known to cause vascular complications. In this study, we tested the hypothesis whether Ang II-induced hypertension...

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Bibliographic Details
Published in:	PloS one Vol. 8; no. 12; p. e83813
Main Authors:	Pushpakumar, Sathnur B., Kundu, Sourav, Metreveli, Naira, Sen, Utpal
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 26.12.2013 Public Library of Science (PLoS)
Subjects:	Acids Angiogenesis Angiostatin Angiotensin Angiotensin II Angiotensin II - pharmacology Animals Arginine - analogs & derivatives Arginine - metabolism Biology Biophysics Blood Blood flow Blood pressure Blood Pressure - drug effects Cardiovascular disease Collagen (type IV) Collagen - metabolism Complications Drinking - drug effects Drinking water Drug dosages Endostatin Fibrosis Folic acid Folic Acid - pharmacology Gelatinase A Gene expression Gene Expression Regulation, Enzymologic - drug effects Homocysteine Homocysteine - blood Hyperhomocysteinemia Hyperhomocysteinemia - complications Hypertension Hypertension - chemically induced Hypertension - complications Hypertension - metabolism Hypertension - physiopathology Immunoglobulins Inflammation Kidney - physiopathology Laboratories Matrix Metalloproteinases - metabolism Medicine Mice Mice, Inbred C57BL Microvasculature mRNA Nitric Oxide - biosynthesis Nitric Oxide Synthase Type III - metabolism Oxidative stress Physiology Plasma Renal function RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Tissue Inhibitor of Metalloproteinases - metabolism Vascular endothelial growth factor Vitamin B United States > US Kentucky
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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