Novel models for prediction of benefit and toxicity with FOLFIRINOX treatment of pancreatic cancer using clinically available parameters

Despite modern chemotherapy regimens, survival of pancreatic cancer patients remains dismal. Toxicity is a major concern and it is a challenge to upfront identify patients with the highest benefit from aggressive polychemotherapy. We aimed to evaluate ORR and side effects of the FOLFIRINOX regimen,...

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Vydáno v:	PloS one Ročník 13; číslo 11; s. e0206688
Hlavní autoři:	Schlick, Konstantin, Magnes, Teresa, Ratzinger, Lukas, Jaud, Bernhard, Weiss, Lukas, Melchardt, Thomas, Greil, Richard, Egle, Alexander
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Public Library of Science 09.11.2018 Public Library of Science (PLoS)
Témata:	Aged Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Bioindicators Biology and Life Sciences Body composition Body composition (biology) Body mass Body mass index Cancer Cancer therapies Chemotherapy Drug Combinations Female Fluorouracil - adverse effects Fluorouracil - therapeutic use Follow-Up Studies Hematology Humans Infectious diseases Inflammation Leucovorin - adverse effects Leucovorin - therapeutic use Male Mathematical models Medical diagnosis Medical personnel Medical research Medicine and Health Sciences Metastases Metastasis Middle Aged Moths Obesity Oncology Organometallic Compounds - adverse effects Organometallic Compounds - therapeutic use Pancreatic cancer Pancreatic Neoplasms - diagnosis Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - mortality Pancreatic Neoplasms - pathology Parameters Patients Physicians Prognosis Research and Analysis Methods Retrospective Studies Rheumatology Risk analysis Risk factors Side effects Survival Survival Analysis Systematic review Thrombocytosis Toxicity Tumor markers Austria
ISSN:	1932-6203, 1932-6203
On-line přístup:	Získat plný text
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