Plasma interleukin-10 levels and adverse outcomes in acute coronary syndrome

PURPOSE OR BACKGROUND: Interleukin (IL)-10 is an immunoregulatory cytokine that is produced by a variety of cell types, such as macrophages and activated monocytes. IL-10 possesses numerous anti-inflammatory, anti-thrombotic and anti-atherosclerotic properties. Furthermore, patients with acute coron...

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Veröffentlicht in:The American journal of medicine Jg. 124; H. 8; S. 724
Hauptverfasser: Cavusoglu, Erdal, Marmur, Jonathan D, Hojjati, Mohammad R, Chopra, Vineet, Butala, Mitul, Subnani, Rakesh, Huda, Mohammad S, Yanamadala, Sunitha, Ruwende, Cyril, Eng, Calvin, Pinsky, David J
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 01.08.2011
Schlagworte:
Acute Coronary Syndrome - blood
Acute Coronary Syndrome - complications
Acute Coronary Syndrome - drug therapy
Acute Coronary Syndrome - mortality
Aged
Angina, Unstable - blood
Angina, Unstable - etiology
Biomarkers - blood
C-Reactive Protein - metabolism
Confounding Factors (Epidemiology)
Hospitals, Veterans - statistics & numerical data
Humans
Interleukin-10 - blood
Kaplan-Meier Estimate
Male
Middle Aged
Multivariate Analysis
Myocardial Infarction - blood
Myocardial Infarction - etiology
Natriuretic Peptide, Brain - blood
New York City - epidemiology
Peptide Fragments - blood
Predictive Value of Tests
Prognosis
Proportional Hazards Models
Prospective Studies
Risk Assessment
Risk Factors
ROC Curve
Time Factors
Treatment Outcome
New York City
ISSN:1555-7162, 1555-7162
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Zusammenfassung:PURPOSE OR BACKGROUND: Interleukin (IL)-10 is an immunoregulatory cytokine that is produced by a variety of cell types, such as macrophages and activated monocytes. IL-10 possesses numerous anti-inflammatory, anti-thrombotic and anti-atherosclerotic properties. Furthermore, patients with acute coronary syndrome have been demonstrated to have reduced levels of IL-10 compared to their stable counterparts. For these reasons, it has been proposed that IL-10 plays a protective role in both atherogenesis and plaque vulnerability. However, 2 short-term studies on the prognostic utility of IL-10 in patients with acute coronary syndrome have provided conflicting results, with one study showing that reduced levels of IL-10 were predictors of adverse outcomes and another showing that elevated levels predicted poor outcomes. The objective of the present study was to investigate the long-term prognostic significance of baseline IL-10 levels in patients with acute coronary syndrome. Baseline plasma IL-10 levels were measured in 193 well-characterized male patients with acute coronary syndrome who were referred for coronary angiography and followed prospectively for 5 years for the development of major adverse cardiovascular events. After controlling for a variety of baseline variables (including established biomarkers such as high-sensitivity C-reactive protein and N-terminal-pro-B-type natriuretic peptide), plasma IL-10 levels (whether analyzed as a continuous variable or as a categorical variable using receiver operating characteristic-derived cut point) were a strong and independent predictor of the composite outcome of death or non-fatal myocardial infarction when using a Cox proportional hazards model. These data demonstrate that, despite biologic plausibility for IL-10 as being a cardioprotective cytokine, elevated baseline plasma levels of IL-10 are a strong and independent predictor of long-term adverse cardiovascular outcomes in patients with acute coronary syndrome.
Bibliographie:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:1555-7162
1555-7162
DOI:10.1016/j.amjmed.2011.02.040