Increased protein and mRNA expression of corticotropin-releasing factor (CRF), decreased CRF receptors and CRF binding protein in specific postmortem brain areas of teenage suicide subjects

•Abnormalities of HPA-axis are associated with depression and suicidal behavior.•CRF expression is increased in PFC, but not in HIPPO of teenage suicide subjects.•We found region-specific changes in the expression of CRF and its receptors.•Increased CRF and decreased CRF-BP and CRF-R1 may be associa...

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Bibliographic Details
Published in:	Psychoneuroendocrinology Vol. 106; pp. 233 - 243
Main Authors:	Pandey, Ghanshyam N., Rizavi, Hooriyah S., Bhaumik, Runa, Ren, Xinguo
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.08.2019
Subjects:	Adolescent Adrenocorticotropic Hormone - metabolism Amygdala - metabolism Autopsy Brain - metabolism Carrier Proteins - metabolism Corticotropin-Releasing Hormone - metabolism Corticotropin-Releasing Hormone - physiology CRF CRF-BP CRF-R1 CRF-R2 Depression Female Hippocampus - metabolism Humans Hypothalamo-Hypophyseal System - metabolism Male Pituitary-Adrenal System - metabolism Postmortem brain Prefrontal Cortex - metabolism Receptors, Corticotropin-Releasing Hormone - metabolism RNA, Messenger - metabolism Suicide - psychology Suicide, Completed - psychology Teenage suicide Young Adult Teenage suicide CRF-BP CRF-R1 Postmortem brain CRF CRF-R2
ISSN:	0306-4530, 1873-3360, 1873-3360
Online Access:	Get full text
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