On the Mechanisms of Biliary Flux
Since the late 1950s, transport of bile in the liver has been described by the “osmotic concept,” according to which bile flows into the canaliculi toward the ducts, countercurrent to the blood flow in the sinusoids. However, because of the small size of canaliculi, it was so far impossible to obser...
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| Vydáno v: | Hepatology (Baltimore, Md.) Ročník 74; číslo 6; s. 3497 - 3512 |
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| Hlavní autoři: | , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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United States
Wolters Kluwer Health, Inc
01.12.2021
Wiley-Blackwell |
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| ISSN: | 0270-9139, 1527-3350, 1527-3350 |
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| Abstract | Since the late 1950s, transport of bile in the liver has been described by the “osmotic concept,” according to which bile flows into the canaliculi toward the ducts, countercurrent to the blood flow in the sinusoids. However, because of the small size of canaliculi, it was so far impossible to observe, let alone to quantify this process. Still, “osmotic canalicular flow” was a sufficient and plausible explanation for the clearance characteristics of a wide variety of choleretic compounds excreted in bile. Imaging techniques have now been established that allow direct flux analysis in bile canaliculi of the intact liver in living organisms. In contrast to the prevailing osmotic concept these analyses strongly suggest that the transport of small molecules in canalicular bile is diffusion dominated, while canalicular flow is negligibly small. In contrast, with the same experimental approach, it could be shown that in the interlobular ducts, diffusion is augmented by flow. Thus, bile canaliculi can be compared to a standing water zone that is connected to a river. The seemingly subtle difference between diffusion and flow is of relevance for therapy of a wide range of liver diseases including cholestasis and NAFLD. Here, we incorporated the latest findings on canalicular solute transport, and align them with extant knowledge to present an integrated and explanatory framework of bile flux that will undoubtedly be refined further in the future. |
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| AbstractList | Since the late 1950s, transport of bile in the liver has been described by the "osmotic concept," according to which bile flows into the canaliculi toward the ducts, countercurrent to the blood flow in the sinusoids. However, because of the small size of canaliculi, it was so far impossible to observe, let alone to quantify this process. Still, "osmotic canalicular flow" was a sufficient and plausible explanation for the clearance characteristics of a wide variety of choleretic compounds excreted in bile. Imaging techniques have now been established that allow direct flux analysis in bile canaliculi of the intact liver in living organisms. In contrast to the prevailing osmotic concept these analyses strongly suggest that the transport of small molecules in canalicular bile is diffusion dominated, while canalicular flow is negligibly small. In contrast, with the same experimental approach, it could be shown that in the interlobular ducts, diffusion is augmented by flow. Thus, bile canaliculi can be compared to a standing water zone that is connected to a river. The seemingly subtle difference between diffusion and flow is of relevance for therapy of a wide range of liver diseases including cholestasis and NAFLD. Here, we incorporated the latest findings on canalicular solute transport, and align them with extant knowledge to present an integrated and explanatory framework of bile flux that will undoubtedly be refined further in the future.Since the late 1950s, transport of bile in the liver has been described by the "osmotic concept," according to which bile flows into the canaliculi toward the ducts, countercurrent to the blood flow in the sinusoids. However, because of the small size of canaliculi, it was so far impossible to observe, let alone to quantify this process. Still, "osmotic canalicular flow" was a sufficient and plausible explanation for the clearance characteristics of a wide variety of choleretic compounds excreted in bile. Imaging techniques have now been established that allow direct flux analysis in bile canaliculi of the intact liver in living organisms. In contrast to the prevailing osmotic concept these analyses strongly suggest that the transport of small molecules in canalicular bile is diffusion dominated, while canalicular flow is negligibly small. In contrast, with the same experimental approach, it could be shown that in the interlobular ducts, diffusion is augmented by flow. Thus, bile canaliculi can be compared to a standing water zone that is connected to a river. The seemingly subtle difference between diffusion and flow is of relevance for therapy of a wide range of liver diseases including cholestasis and NAFLD. Here, we incorporated the latest findings on canalicular solute transport, and align them with extant knowledge to present an integrated and explanatory framework of bile flux that will undoubtedly be refined further in the future. Since the late 1950s, transport of bile in the liver has been described by the "osmotic concept," according to which bile flows into the canaliculi toward the ducts, countercurrent to the blood flow in the sinusoids. However, because of the small size of canaliculi, it was so far impossible to observe, let alone to quantify this process. Still, "osmotic canalicular flow" was a sufficient and plausible explanation for the clearance characteristics of a wide variety of choleretic compounds excreted in bile. Imaging techniques have now been established that allow direct flux analysis in bile canaliculi of the intact liver in living organisms. In contrast to the prevailing osmotic concept these analyses strongly suggest that the transport of small molecules in canalicular bile is diffusion dominated, while canalicular flow is negligibly small. In contrast, with the same experimental approach, it could be shown that in the interlobular ducts, diffusion is augmented by flow. Thus, bile canaliculi can be compared to a standing water zone that is connected to a river. The seemingly subtle difference between diffusion and flow is of relevance for therapy of a wide range of liver diseases including cholestasis and NAFLD. Here, we incorporated the latest findings on canalicular solute transport, and align them with extant knowledge to present an integrated and explanatory framework of bile flux that will undoubtedly be refined further in the future. |
| Author | Trauner, Michael P.J.Oude Elferink, Ronald Geisler, Fabian Jansen, Peter Graaf, Stan F.J. Drasdo, Dirk Chiang, John Keitel, Verena Vartak, Nachiket Itoh, Tohru Hengstler, Jan G. |
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| Cites_doi | 10.1152/ajpcell.00369.2007 10.1152/ajpgi.2001.281.3.G612 10.1042/BC20040089 10.1002/hep.28373 10.1172/JCI114189 10.1002/j.2040-4603.2013.tb00519.x 10.1002/hep.20996 10.1186/s12964-015-0107-9 10.1016/j.cels.2017.02.008 10.1111/nyas.13383 10.3390/ijms19123913 10.1053/jhep.2000.7986 10.1007/BF00646787 10.1152/physrev.1984.64.4.1055 10.1016/S0016-5085(79)91329-5 10.1210/me.2010-0460 10.1038/s42003-020-1006-1 10.1002/hep.22891 10.1016/j.jhep.2015.02.023 10.1002/hep.31422 10.1007/BF01243172 10.1016/S0031-6997(25)07389-2 10.1002/hep.30213 10.1152/ajpgi.90226.2008 10.1074/jbc.M202394200 10.1074/jbc.M212079200 10.1677/joe.1.06546 10.1172/JCI105612 10.1002/hep.1840210435 10.1002/hep.23883 10.1159/000324121 10.1002/hep.1840060625 10.1038/s41591-019-0660-7 10.1172/JCI107817 10.1053/j.gastro.2014.07.033 10.1002/hep.510230205 10.1172/JCI78585 10.1152/ajpgi.00383.2012 10.1152/ajplegacy.1954.177.1.103 10.3748/wjg.v12.i22.3496 |
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| References | 1989; 84 2015; 13 1984; 64 2013; 3 1974; 54 2017; 4 2006; 12 2006; 98 2001; 281 2015; 125 2002; 277 2015; 10 2013; 304 1978; 234 1967; 46 2006; 191 1978; 235 2003; 278 2021; 73 1979; 76 2009; 49 1993; 265 2018; 19 1997; 127 2018; 1864 2020; 3 2006; 43 2015; 62 2017; 1397 2019; 25 1995; 21 2000; 31 1986; 6 2019; 69 2016; 63 1954; 177 2011; 25 2011; 29 2014; 147 2008; 295 2010; 52 1959; 11 1979; 8 1996; 23 (hep32027-bib-0008-20250824) 2013; 3 (hep32027-bib-0011-20250824) 1984; 64 (hep32027-bib-0042-20250824) 2016; 63 (hep32027-bib-0014-20250824) 1997; 127 (hep32027-bib-0021-20250824) 2003; 278 (hep32027-bib-0040-20250824) 2001; 281 (hep32027-bib-0007-20250824) 1978; 234 (hep32027-bib-0009-20250824) 1993; 265 (hep32027-bib-0015-20250824) 1989; 84 (hep32027-bib-0043-20250824) 2015; 62 (hep32027-bib-0002-20250824) 2017; 4 (hep32027-bib-0003-20250824) 2019; 25 (hep32027-bib-0036-20250824) 2010; 52 (hep32027-bib-0005-20250824) 1959; 11 (hep32027-bib-0032-20250824) 2006; 191 (hep32027-bib-0039-20250824) 2011; 29 (hep32027-bib-0018-20250824) 2002; 277 (hep32027-bib-0044-20250824) 2009; 49 (hep32027-bib-0024-20250824) 1967; 46 (hep32027-bib-0028-20250824) 1996; 23 (hep32027-bib-0030-20250824) 2011; 25 (hep32027-bib-0022-20250824) 2006; 98 (hep32027-bib-0027-20250824) 1986; 6 (hep32027-bib-0004-20250824) 2015; 125 (hep32027-bib-0010-20250824) 1978; 235 (hep32027-bib-0033-20250824) 2013; 304 (hep32027-bib-0012-20250824) 1995; 21 (hep32027-bib-0013-20250824) 1979; 8 (hep32027-bib-0038-20250824) 2018; 19 (hep32027-bib-0045-20250824) 2019; 69 (hep32027-bib-0025-20250824) 1974; 54 (hep32027-bib-0029-20250824) 2018; 1864 (hep32027-bib-0001-20250824) 2021; 73 (hep32027-bib-0020-20250824) 2006; 43 (hep32027-bib-0034-20250824) 2006; 12 (hep32027-bib-0037-20250824) 2008; 295 (hep32027-bib-0019-20250824) 2008; 295 (hep32027-bib-0041-20250824) 2020; 3 (hep32027-bib-0031-20250824) 2015; 10 (hep32027-bib-0006-20250824) 1954; 177 (hep32027-bib-0026-20250824) 1979; 76 (hep32027-bib-0035-20250824) 2015; 13 (hep32027-bib-0017-20250824) 2014; 147 (hep32027-bib-0023-20250824) 2000; 31 (hep32027-bib-0016-20250824) 2017; 1397 34957580 - Hepatology. 2022 Apr;75(4):1061 |
| References_xml | – volume: 21 start-page: 1120 year: 1995 end-page: 1129 article-title: Functional and ultrastructural features of ethanol/bile salts interaction in the isolated perfused rat liver publication-title: Hepatology – volume: 84 start-page: 476 year: 1989 end-page: 483 article-title: Hepatobiliary transport of glutathione and glutathione conjugate in rats with hereditary hyperbilirubinemia publication-title: J Clin Invest – volume: 125 start-page: 2445 year: 2015 end-page: 2457 article-title: Lineage fate of ductular reactions in liver injury and carcinogenesis publication-title: J Clin Invest – volume: 295 start-page: G682 year: 2008 end-page: G690 article-title: Altered expression and distribution of aquaporin‐9 in the liver of rat with obstructive extrahepatic cholestasis publication-title: Am J Physiol Gastrointest Liver Physiol – volume: 25 start-page: 1066 year: 2011 end-page: 1071 article-title: The G protein‐coupled bile acid receptor, TGR5, stimulates gallbladder filling publication-title: Mol Endocrinol – volume: 177 start-page: 103 year: 1954 end-page: 112 article-title: Mechanics of bile secretion publication-title: Am J Physiol – volume: 98 start-page: 43 year: 2006 end-page: 52 article-title: Cytoskeletal and motor proteins facilitate trafficking of AQP1‐containing vesicles in cholangiocytes publication-title: Biol Cell – volume: 19 start-page: 3913 year: 2018 article-title: Calcium signaling in cholangiocytes: methods, mechanisms, and effects publication-title: Int J Mol Sci – volume: 63 start-page: 951 year: 2016 end-page: 964 article-title: Cholestasis‐induced adaptive remodeling of interlobular bile ducts publication-title: Hepatology – volume: 43 start-page: S75 year: 2006 end-page: S81 article-title: Aquaporins in the hepatobiliary system publication-title: Hepatology – volume: 11 start-page: 109 year: 1959 end-page: 134 article-title: Secretion of organic anions in the formation of urine and bile publication-title: Pharmacol Rev – volume: 54 start-page: 773 year: 1974 end-page: 781 article-title: Canalicular bile secretion in man. Studies utilizing the biliary clearance of [14c]mannitol publication-title: J Clin Invest – volume: 49 start-page: 1972 year: 2009 end-page: 1981 article-title: Side chain structure determines unique physiologic and therapeutic properties of norursodeoxycholic acid in Mdr2‐/‐ mice publication-title: Hepatology – volume: 234 start-page: E584 year: 1978 end-page: E592 article-title: Hemodynamic effects on determinants of bile secretion in isolated rat liver publication-title: Am J Physiol – volume: 127 start-page: 101 year: 1997 end-page: 104 article-title: Determination of critical micelle concentration of bile acid salts by micro‐calorimetric titration publication-title: Microchim Acta – volume: 265 start-page: G445 year: 1993 end-page: G452 article-title: Preserved organic anion transport in mutant TR‐ rats with a hepatobiliary secretion defect publication-title: Am J Physiol – volume: 4 start-page: 277 year: 2017 end-page: 290.e9 article-title: A predictive 3D multi‐scale model of biliary fluid dynamics in the liver lobule publication-title: Cell Syst – volume: 1864 start-page: 1319 issue: 4 Pt B year: 2018 end-page: 1325 article-title: Bile acid receptors in the biliary tree: TGR5 in physiology and disease publication-title: Biochim Biophys Acta Mol Basis Dis – volume: 304 start-page: G1013 year: 2013 end-page: G1024 article-title: Ciliary subcellular localization of TGR5 determines the cholangiocyte functional response to bile acid signaling publication-title: Am J Physiol Gastrointest Liver Physiol – volume: 31 start-page: 1313 year: 2000 end-page: 1317 article-title: Expression of aquaporin‐4 water channels in rat cholangiocytes publication-title: Hepatology – volume: 6 start-page: 1369 year: 1986 end-page: 1381 article-title: Permeability characteristics of the guinea pig biliary apparatus publication-title: Hepatology – volume: 191 start-page: 197 year: 2006 end-page: 205 article-title: Targeted disruption of G protein‐coupled bile acid receptor 1 (Gpbar1/M‐Bar) in mice publication-title: J Endocrinol – volume: 62 start-page: S25 year: 2015 end-page: S37 article-title: New paradigms in the treatment of hepatic cholestasis: from UDCA to FXR, PXR and beyond publication-title: J Hepatol – volume: 29 start-page: 6 year: 2011 end-page: 12 article-title: The role of cilia in the regulation of bile flow publication-title: Dig Dis – volume: 69 start-page: 666 year: 2019 end-page: 683 article-title: Bile micro‐infarcts in cholestasis are initiated by rupture of the apical hepatocyte membrane and cause shunting of bile to sinusoidal blood publication-title: Hepatology – volume: 8 start-page: 347 year: 1979 end-page: 357 article-title: Osmotic and activity coefficients of aqueous bile salt solutions at 25, 37, and 45°C publication-title: J Solut Chem – volume: 46 start-page: 1189 year: 1967 end-page: 1195 article-title: Two sites of bile formation as determined by mannitol and erythritol clearance in the guinea pig publication-title: J Clin Invest – volume: 235 start-page: E158 year: 1978 end-page: E164 article-title: Importance of bicarbonate in bile salt independent fraction of bile flow publication-title: Am J Physiol – volume: 13 start-page: 28 year: 2015 article-title: Bile acid effects are mediated by ATP release and purinergic signalling in exocrine pancreatic cells publication-title: Cell Commun Signal – volume: 277 start-page: 22710 year: 2002 end-page: 22717 article-title: Expression and localization of aquaporin water channels in rat hepatocytes publication-title: J Biol Chem – volume: 25 start-page: 1885 year: 2019 end-page: 1893 article-title: Three‐dimensional spatially resolved geometrical and functional models of human liver tissue reveal new aspects of NAFLD progression publication-title: Nat Med – volume: 64 start-page: 1055 year: 1984 end-page: 1102 article-title: Hepatic bile flow publication-title: Physiol Rev – volume: 1397 start-page: 100 year: 2017 end-page: 109 article-title: Water channels and barriers formed by claudins publication-title: Ann N Y Acad Sci – volume: 281 start-page: G612 year: 2001 end-page: G625 article-title: Regulation of cholangiocyte bicarbonate secretion publication-title: Am J Physiol Gastrointest Liver Physiol – volume: 76 start-page: 983 year: 1979 end-page: 987 article-title: Biliary mannitol clearance and bile salt output before and during secretin choleresis in the dog publication-title: Gastroenterology – volume: 3 start-page: 289 year: 2020 article-title: Multidimensional imaging of liver injury repair in mice reveals fundamental role of the ductular reaction publication-title: Commun Biol – volume: 147 start-page: 1134 year: 2014 end-page: 1145.e10 article-title: Claudin 2 deficiency reduces bile flow and increases susceptibility to cholesterol gallstone disease in mice publication-title: Gastroenterology – volume: 3 start-page: 1035 year: 2013 end-page: 1078 article-title: Bile formation and secretion publication-title: Compr Physiol – volume: 12 start-page: 3496 year: 2006 end-page: 3511 article-title: Cholangiocyte anion exchange and biliary bicarbonate excretion publication-title: World J Gastroenterol – volume: 10 year: 2015 article-title: Cholic acid induces a Cftr dependent biliary secretion and liver growth response in mice publication-title: PLoS One – volume: 295 start-page: C499 year: 2008 end-page: C513 article-title: Small mouse cholangiocytes proliferate in response to H1 histamine receptor stimulation by activation of the IP3/CaMK I/CREB pathway publication-title: Am J Physiol Cell Physiol – volume: 278 start-page: 6268 year: 2003 end-page: 6274 article-title: Specific inhibition of AQP1 water channels in isolated rat intrahepatic bile duct units by small interfering RNAs publication-title: J Biol Chem – volume: 52 start-page: 1819 year: 2010 end-page: 1828 article-title: Adenosine triphosphate release and purinergic (P2) receptor–mediated secretion in small and large mouse cholangiocytes publication-title: Hepatology – volume: 73 start-page: 1531 year: 2021 end-page: 1550 article-title: Intravital dynamic and correlative imaging reveals diffusion‐dominated canalicular and flow‐augmented ductular bile flux publication-title: Hepatology – volume: 23 start-page: 229 year: 1996 end-page: 233 article-title: The effect of mannitol and secretin on the biliary transport of urate in humans publication-title: Hepatology – volume: 295 start-page: C499 year: 2008 ident: hep32027-bib-0037-20250824 article-title: Small mouse cholangiocytes proliferate in response to H1 histamine receptor stimulation by activation of the IP3/CaMK I/CREB pathway publication-title: Am J Physiol Cell Physiol doi: 10.1152/ajpcell.00369.2007 – volume: 281 start-page: G612 year: 2001 ident: hep32027-bib-0040-20250824 article-title: Regulation of cholangiocyte bicarbonate secretion publication-title: Am J Physiol Gastrointest Liver Physiol doi: 10.1152/ajpgi.2001.281.3.G612 – volume: 1864 start-page: 1319 issue: 4 Pt B year: 2018 ident: hep32027-bib-0029-20250824 article-title: Bile acid receptors in the biliary tree: TGR5 in physiology and disease publication-title: Biochim Biophys Acta Mol Basis Dis – volume: 98 start-page: 43 year: 2006 ident: hep32027-bib-0022-20250824 article-title: Cytoskeletal and motor proteins facilitate trafficking of AQP1‐containing vesicles in cholangiocytes publication-title: Biol Cell doi: 10.1042/BC20040089 – volume: 63 start-page: 951 year: 2016 ident: hep32027-bib-0042-20250824 article-title: Cholestasis‐induced adaptive remodeling of interlobular bile ducts publication-title: Hepatology doi: 10.1002/hep.28373 – volume: 84 start-page: 476 year: 1989 ident: hep32027-bib-0015-20250824 article-title: Hepatobiliary transport of glutathione and glutathione conjugate in rats with hereditary hyperbilirubinemia publication-title: J Clin Invest doi: 10.1172/JCI114189 – volume: 3 start-page: 1035 year: 2013 ident: hep32027-bib-0008-20250824 article-title: Bile formation and secretion publication-title: Compr Physiol doi: 10.1002/j.2040-4603.2013.tb00519.x – volume: 43 start-page: S75 year: 2006 ident: hep32027-bib-0020-20250824 article-title: Aquaporins in the hepatobiliary system publication-title: Hepatology doi: 10.1002/hep.20996 – volume: 13 start-page: 28 year: 2015 ident: hep32027-bib-0035-20250824 article-title: Bile acid effects are mediated by ATP release and purinergic signalling in exocrine pancreatic cells publication-title: Cell Commun Signal doi: 10.1186/s12964-015-0107-9 – volume: 4 start-page: 277 year: 2017 ident: hep32027-bib-0002-20250824 article-title: A predictive 3D multi‐scale model of biliary fluid dynamics in the liver lobule publication-title: Cell Syst doi: 10.1016/j.cels.2017.02.008 – volume: 1397 start-page: 100 year: 2017 ident: hep32027-bib-0016-20250824 article-title: Water channels and barriers formed by claudins publication-title: Ann N Y Acad Sci doi: 10.1111/nyas.13383 – volume: 19 start-page: 3913 year: 2018 ident: hep32027-bib-0038-20250824 article-title: Calcium signaling in cholangiocytes: methods, mechanisms, and effects publication-title: Int J Mol Sci doi: 10.3390/ijms19123913 – volume: 10 year: 2015 ident: hep32027-bib-0031-20250824 article-title: Cholic acid induces a Cftr dependent biliary secretion and liver growth response in mice publication-title: PLoS One – volume: 31 start-page: 1313 year: 2000 ident: hep32027-bib-0023-20250824 article-title: Expression of aquaporin‐4 water channels in rat cholangiocytes publication-title: Hepatology doi: 10.1053/jhep.2000.7986 – volume: 8 start-page: 347 year: 1979 ident: hep32027-bib-0013-20250824 article-title: Osmotic and activity coefficients of aqueous bile salt solutions at 25, 37, and 45°C publication-title: J Solut Chem doi: 10.1007/BF00646787 – volume: 64 start-page: 1055 year: 1984 ident: hep32027-bib-0011-20250824 article-title: Hepatic bile flow publication-title: Physiol Rev doi: 10.1152/physrev.1984.64.4.1055 – volume: 76 start-page: 983 year: 1979 ident: hep32027-bib-0026-20250824 article-title: Biliary mannitol clearance and bile salt output before and during secretin choleresis in the dog publication-title: Gastroenterology doi: 10.1016/S0016-5085(79)91329-5 – volume: 25 start-page: 1066 year: 2011 ident: hep32027-bib-0030-20250824 article-title: The G protein‐coupled bile acid receptor, TGR5, stimulates gallbladder filling publication-title: Mol Endocrinol doi: 10.1210/me.2010-0460 – volume: 3 start-page: 289 year: 2020 ident: hep32027-bib-0041-20250824 article-title: Multidimensional imaging of liver injury repair in mice reveals fundamental role of the ductular reaction publication-title: Commun Biol doi: 10.1038/s42003-020-1006-1 – volume: 234 start-page: E584 year: 1978 ident: hep32027-bib-0007-20250824 article-title: Hemodynamic effects on determinants of bile secretion in isolated rat liver publication-title: Am J Physiol – volume: 49 start-page: 1972 year: 2009 ident: hep32027-bib-0044-20250824 article-title: Side chain structure determines unique physiologic and therapeutic properties of norursodeoxycholic acid in Mdr2‐/‐ mice publication-title: Hepatology doi: 10.1002/hep.22891 – volume: 62 start-page: S25 year: 2015 ident: hep32027-bib-0043-20250824 article-title: New paradigms in the treatment of hepatic cholestasis: from UDCA to FXR, PXR and beyond publication-title: J Hepatol doi: 10.1016/j.jhep.2015.02.023 – volume: 73 start-page: 1531 year: 2021 ident: hep32027-bib-0001-20250824 article-title: Intravital dynamic and correlative imaging reveals diffusion‐dominated canalicular and flow‐augmented ductular bile flux publication-title: Hepatology doi: 10.1002/hep.31422 – volume: 127 start-page: 101 year: 1997 ident: hep32027-bib-0014-20250824 article-title: Determination of critical micelle concentration of bile acid salts by micro‐calorimetric titration publication-title: Microchim Acta doi: 10.1007/BF01243172 – volume: 11 start-page: 109 year: 1959 ident: hep32027-bib-0005-20250824 article-title: Secretion of organic anions in the formation of urine and bile publication-title: Pharmacol Rev doi: 10.1016/S0031-6997(25)07389-2 – volume: 69 start-page: 666 year: 2019 ident: hep32027-bib-0045-20250824 article-title: Bile micro‐infarcts in cholestasis are initiated by rupture of the apical hepatocyte membrane and cause shunting of bile to sinusoidal blood publication-title: Hepatology doi: 10.1002/hep.30213 – volume: 295 start-page: G682 year: 2008 ident: hep32027-bib-0019-20250824 article-title: Altered expression and distribution of aquaporin‐9 in the liver of rat with obstructive extrahepatic cholestasis publication-title: Am J Physiol Gastrointest Liver Physiol doi: 10.1152/ajpgi.90226.2008 – volume: 277 start-page: 22710 year: 2002 ident: hep32027-bib-0018-20250824 article-title: Expression and localization of aquaporin water channels in rat hepatocytes publication-title: J Biol Chem doi: 10.1074/jbc.M202394200 – volume: 278 start-page: 6268 year: 2003 ident: hep32027-bib-0021-20250824 article-title: Specific inhibition of AQP1 water channels in isolated rat intrahepatic bile duct units by small interfering RNAs publication-title: J Biol Chem doi: 10.1074/jbc.M212079200 – volume: 265 start-page: G445 year: 1993 ident: hep32027-bib-0009-20250824 article-title: Preserved organic anion transport in mutant TR‐ rats with a hepatobiliary secretion defect publication-title: Am J Physiol – volume: 191 start-page: 197 year: 2006 ident: hep32027-bib-0032-20250824 article-title: Targeted disruption of G protein‐coupled bile acid receptor 1 (Gpbar1/M‐Bar) in mice publication-title: J Endocrinol doi: 10.1677/joe.1.06546 – volume: 46 start-page: 1189 year: 1967 ident: hep32027-bib-0024-20250824 article-title: Two sites of bile formation as determined by mannitol and erythritol clearance in the guinea pig publication-title: J Clin Invest doi: 10.1172/JCI105612 – volume: 21 start-page: 1120 year: 1995 ident: hep32027-bib-0012-20250824 article-title: Functional and ultrastructural features of ethanol/bile salts interaction in the isolated perfused rat liver publication-title: Hepatology doi: 10.1002/hep.1840210435 – volume: 52 start-page: 1819 year: 2010 ident: hep32027-bib-0036-20250824 article-title: Adenosine triphosphate release and purinergic (P2) receptor–mediated secretion in small and large mouse cholangiocytes publication-title: Hepatology doi: 10.1002/hep.23883 – volume: 29 start-page: 6 year: 2011 ident: hep32027-bib-0039-20250824 article-title: The role of cilia in the regulation of bile flow publication-title: Dig Dis doi: 10.1159/000324121 – volume: 6 start-page: 1369 year: 1986 ident: hep32027-bib-0027-20250824 article-title: Permeability characteristics of the guinea pig biliary apparatus publication-title: Hepatology doi: 10.1002/hep.1840060625 – volume: 25 start-page: 1885 year: 2019 ident: hep32027-bib-0003-20250824 article-title: Three‐dimensional spatially resolved geometrical and functional models of human liver tissue reveal new aspects of NAFLD progression publication-title: Nat Med doi: 10.1038/s41591-019-0660-7 – volume: 54 start-page: 773 year: 1974 ident: hep32027-bib-0025-20250824 article-title: Canalicular bile secretion in man. Studies utilizing the biliary clearance of [14c]mannitol publication-title: J Clin Invest doi: 10.1172/JCI107817 – volume: 235 start-page: E158 year: 1978 ident: hep32027-bib-0010-20250824 article-title: Importance of bicarbonate in bile salt independent fraction of bile flow publication-title: Am J Physiol – volume: 147 start-page: 1134 year: 2014 ident: hep32027-bib-0017-20250824 article-title: Claudin 2 deficiency reduces bile flow and increases susceptibility to cholesterol gallstone disease in mice publication-title: Gastroenterology doi: 10.1053/j.gastro.2014.07.033 – volume: 23 start-page: 229 year: 1996 ident: hep32027-bib-0028-20250824 article-title: The effect of mannitol and secretin on the biliary transport of urate in humans publication-title: Hepatology doi: 10.1002/hep.510230205 – volume: 125 start-page: 2445 year: 2015 ident: hep32027-bib-0004-20250824 article-title: Lineage fate of ductular reactions in liver injury and carcinogenesis publication-title: J Clin Invest doi: 10.1172/JCI78585 – volume: 304 start-page: G1013 year: 2013 ident: hep32027-bib-0033-20250824 article-title: Ciliary subcellular localization of TGR5 determines the cholangiocyte functional response to bile acid signaling publication-title: Am J Physiol Gastrointest Liver Physiol doi: 10.1152/ajpgi.00383.2012 – volume: 177 start-page: 103 year: 1954 ident: hep32027-bib-0006-20250824 article-title: Mechanics of bile secretion publication-title: Am J Physiol doi: 10.1152/ajplegacy.1954.177.1.103 – volume: 12 start-page: 3496 year: 2006 ident: hep32027-bib-0034-20250824 article-title: Cholangiocyte anion exchange and biliary bicarbonate excretion publication-title: World J Gastroenterol doi: 10.3748/wjg.v12.i22.3496 – reference: 34957580 - Hepatology. 2022 Apr;75(4):1061 |
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| SubjectTerms | Animals Bile Bile - metabolism Bile Acids and Salts - metabolism Bile ducts Bile Ducts - metabolism Blood flow Cholestasis Computer Science Diffusion Fatty liver Hepatology Humans Liver - metabolism Liver diseases Mice Modeling and Simulation Osmosis |
| Title | On the Mechanisms of Biliary Flux |
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