Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors

Tumor-associated macrophages (TAM) contribute to all aspects of tumor progression. Use of CSF1R inhibitors to target TAM is therapeutically appealing, but has had very limited anti-tumor effects. Here, we have identified the mechanism that limited the effect of CSF1R targeted therapy. We demonstrate...

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Bibliographic Details
Published in:	Cancer cell Vol. 32; no. 5; p. 654
Main Authors:	Kumar, Vinit, Donthireddy, Laxminarasimha, Marvel, Douglas, Condamine, Thomas, Wang, Fang, Lavilla-Alonso, Sergio, Hashimoto, Ayumi, Vonteddu, Prashanthi, Behera, Reeti, Goins, Marlee A, Mulligan, Charles, Nam, Brian, Hockstein, Neil, Denstman, Fred, Shakamuri, Shanti, Speicher, David W, Weeraratna, Ashani T, Chao, Timothy, Vonderheide, Robert H, Languino, Lucia R, Ordentlich, Peter, Liu, Qin, Xu, Xiaowei, Lo, Albert, Puré, Ellen, Zhang, Chunsheng, Loboda, Andrey, Sepulveda, Manuel A, Snyder, Linda A, Gabrilovich, Dmitry I
Format:	Journal Article
Language:	English
Published:	United States 13.11.2017
Subjects:	Animals Cancer-Associated Fibroblasts - drug effects Cancer-Associated Fibroblasts - metabolism Cell Line, Tumor Granulocytes - metabolism Histone Deacetylase 2 Humans Imidazoles - pharmacology Macrophages - metabolism Mice, Inbred C57BL Monocytes - metabolism Myeloid-Derived Suppressor Cells - metabolism Neoplasms, Experimental - drug therapy Neoplasms, Experimental - metabolism Neoplasms, Experimental - pathology Phenylurea Compounds - pharmacology Pyridines - pharmacology Receptor, Macrophage Colony-Stimulating Factor - antagonists & inhibitors Receptor, Macrophage Colony-Stimulating Factor - metabolism Receptors, Interleukin-8B - antagonists & inhibitors Receptors, Interleukin-8B - metabolism Tumor Burden - drug effects granulocytes CSF1R fibroblasts macrophages M-CSF PMN-MDSC
ISSN:	1878-3686, 1878-3686
Online Access:	Get more information
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