Role of Matrix Metalloproteinases in Angiogenesis and Cancer

During angiogenesis, new vessels emerge from existing endothelial lined vessels to promote the degradation of the vascular basement membrane and remodel the extracellular matrix (ECM), followed by endothelial cell migration, and proliferation and the new generation of matrix components. Matrix metal...

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Bibliographic Details
Published in:Frontiers in oncology Vol. 9; p. 1370
Main Authors: Quintero-Fabián, Saray, Arreola, Rodrigo, Becerril-Villanueva, Enrique, Torres-Romero, Julio César, Arana-Argáez, Victor, Lara-Riegos, Julio, Ramírez-Camacho, Mario Alberto, Alvarez-Sánchez, María Elizbeth
Format: Journal Article
Language:English
Published: Switzerland Frontiers Media S.A 06.12.2019
Subjects:
angiogenesis and cancer
immune system
metalloproteinases
MMP
MT-MMP
Oncology
MT-MMP
immune system
metalloproteinases
MMP
angiogenesis and cancer
ISSN:2234-943X, 2234-943X
Online Access:Get full text
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Summary:During angiogenesis, new vessels emerge from existing endothelial lined vessels to promote the degradation of the vascular basement membrane and remodel the extracellular matrix (ECM), followed by endothelial cell migration, and proliferation and the new generation of matrix components. Matrix metalloproteinases (MMPs) participate in the disruption, tumor neovascularization, and subsequent metastasis while tissue inhibitors of metalloproteinases (TIMPs) downregulate the activity of these MMPs. Then, the angiogenic response can be directly or indirectly mediated by MMPs through the modulation of the balance between pro- and anti-angiogenic factors. This review analyzes recent knowledge on MMPs and their participation in angiogenesis.
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Reviewed by: Linda C. Meade-Tollin, University of Arizona, United States; Ronca Roberto, University of Brescia, Italy
This article was submitted to Molecular and Cellular Oncology, a section of the journal Frontiers in Oncology
These authors have contributed equally to this work
Edited by: Erika Ruiz-Garcia, National Institute of Cancerology (INCan), Mexico
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2019.01370