Shaping the Gut Microbiota by Breastfeeding: The Gateway to Allergy Prevention?

Evidence is accumulating that demonstrates the importance of the gut microbiota in health and diseases such as allergy. Recent studies emphasize the importance of the "window of opportunity" in early life, during which interventions altering the gut microbiota induce long-term effects. The...

Full description

Saved in:

Bibliographic Details
Published in:	Frontiers in pediatrics Vol. 7; p. 47
Main Authors:	van den Elsen, Lieke W. J., Garssen, Johan, Burcelin, Remy, Verhasselt, Valerie
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 27.02.2019
Subjects:	allergy breastmilk gut microbiota neonate Pediatrics prevention allergy neonate breastmilk gut microbiota prevention
ISSN:	2296-2360, 2296-2360
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	Evidence is accumulating that demonstrates the importance of the gut microbiota in health and diseases such as allergy. Recent studies emphasize the importance of the "window of opportunity" in early life, during which interventions altering the gut microbiota induce long-term effects. The neonate's gut microbiota composition and metabolism could therefore play an essential role in allergic disease risk. Breastfeeding shapes the gut microbiota in early life, both directly by exposure of the neonate to the milk microbiota and indirectly, via maternal milk factors that affect bacterial growth and metabolism such as human milk oligosaccharides, secretory IgA, and anti-microbial factors. The potential of breastmilk to modulate the offspring's early gut microbiota is a promising tool for allergy prevention. Here, we will review the existing evidence demonstrating the impact of breastfeeding on shaping the neonate's gut microbiota and highlight the potential of this strategy for allergy prevention.
AbstractList	Evidence is accumulating that demonstrates the importance of the gut microbiota in health and diseases such as allergy. Recent studies emphasize the importance of the "window of opportunity" in early life, during which interventions altering the gut microbiota induce long-term effects. The neonate's gut microbiota composition and metabolism could therefore play an essential role in allergic disease risk. Breastfeeding shapes the gut microbiota in early life, both directly by exposure of the neonate to the milk microbiota and indirectly, via maternal milk factors that affect bacterial growth and metabolism such as human milk oligosaccharides, secretory IgA, and anti-microbial factors. The potential of breastmilk to modulate the offspring's early gut microbiota is a promising tool for allergy prevention. Here, we will review the existing evidence demonstrating the impact of breastfeeding on shaping the neonate's gut microbiota and highlight the potential of this strategy for allergy prevention. Evidence is accumulating that demonstrates the importance of the gut microbiota in health and diseases such as allergy. Recent studies emphasize the importance of the "window of opportunity" in early life, during which interventions altering the gut microbiota induce long-term effects. The neonate's gut microbiota composition and metabolism could therefore play an essential role in allergic disease risk. Breastfeeding shapes the gut microbiota in early life, both directly by exposure of the neonate to the milk microbiota and indirectly, via maternal milk factors that affect bacterial growth and metabolism such as human milk oligosaccharides, secretory IgA, and anti-microbial factors. The potential of breastmilk to modulate the offspring's early gut microbiota is a promising tool for allergy prevention. Here, we will review the existing evidence demonstrating the impact of breastfeeding on shaping the neonate's gut microbiota and highlight the potential of this strategy for allergy prevention.Evidence is accumulating that demonstrates the importance of the gut microbiota in health and diseases such as allergy. Recent studies emphasize the importance of the "window of opportunity" in early life, during which interventions altering the gut microbiota induce long-term effects. The neonate's gut microbiota composition and metabolism could therefore play an essential role in allergic disease risk. Breastfeeding shapes the gut microbiota in early life, both directly by exposure of the neonate to the milk microbiota and indirectly, via maternal milk factors that affect bacterial growth and metabolism such as human milk oligosaccharides, secretory IgA, and anti-microbial factors. The potential of breastmilk to modulate the offspring's early gut microbiota is a promising tool for allergy prevention. Here, we will review the existing evidence demonstrating the impact of breastfeeding on shaping the neonate's gut microbiota and highlight the potential of this strategy for allergy prevention.
Author	Garssen, Johan van den Elsen, Lieke W. J. Verhasselt, Valerie Burcelin, Remy
AuthorAffiliation	1 School of Molecular Sciences, University of Western Australia , Perth, WA , Australia 2 Division of Pharmacology, Faculty of Science, Utrecht Institute of Pharmaceutical Sciences, Utrecht University , Utrecht , Netherlands 3 Institut National de la Santé et de la Recherche Médicale (INSERM) , Toulouse , France
AuthorAffiliation_xml	– name: 2 Division of Pharmacology, Faculty of Science, Utrecht Institute of Pharmaceutical Sciences, Utrecht University , Utrecht , Netherlands – name: 1 School of Molecular Sciences, University of Western Australia , Perth, WA , Australia – name: 3 Institut National de la Santé et de la Recherche Médicale (INSERM) , Toulouse , France
Author_xml	– sequence: 1 givenname: Lieke W. J. surname: van den Elsen fullname: van den Elsen, Lieke W. J. – sequence: 2 givenname: Johan surname: Garssen fullname: Garssen, Johan – sequence: 3 givenname: Remy surname: Burcelin fullname: Burcelin, Remy – sequence: 4 givenname: Valerie surname: Verhasselt fullname: Verhasselt, Valerie
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/30873394$$D View this record in MEDLINE/PubMed
BookMark	eNp1kUtv1DAURi1URB90zQ55yWamfsSJzQLUVqVUKioSZW3d2DczrjLx4HiK5t_jdErVIrGy5Zz7fY7PIdkb4oCEvONsLqU2J90a_VwwbuaMsap5RQ6EMPVMyJrtPdvvk-NxvCsIMw1TXL0h-5LpRkpTHZCbH0tYh2FB8xLp5SbTb8Gl2IaYgbZbepYQxtwh-sJ8pLcTBBl_w5bmSE_7HtNiS78nvMchhzh8fkted9CPePy4HpGfXy5uz7_Orm8ur85Pr2dOCZVnXkow2hjlTN1p41mlWdtopZXjyIyqHDIJEhyDTjTAUWuOQtcoWxC8quQRudrl-gh3dp3CCtLWRgj24SCmhYWUg-vReq09YIVKSqykLk2d8A5Kk1ZNq3TJ-rTLWm_aFXpXfiVB_yL05ZchLO0i3tu6Km-q6xLw4TEgxV8bHLNdhdFh38OAcTNawY3kDWdqQt8_73oq-WukACc7oGgYx4TdE8KZnbTbSbudtNsH7WVC_TPhQobJRrls6P879wcvoLD9
CitedBy_id	crossref_primary_10_3389_fmed_2024_1377186 crossref_primary_10_1002_fsn3_70788 crossref_primary_10_3390_antiox14091078 crossref_primary_10_3390_brainsci15030253 crossref_primary_10_1016_j_anai_2021_04_025 crossref_primary_10_1093_ecco_jcc_jjad096 crossref_primary_10_1080_1040841X_2019_1680601 crossref_primary_10_1093_ismeco_ycad019 crossref_primary_10_1080_19490976_2023_2295403 crossref_primary_10_3390_ijerph20021463 crossref_primary_10_1038_s41467_025_61998_2 crossref_primary_10_3390_microorganisms8081119 crossref_primary_10_3389_fmicb_2023_1236254 crossref_primary_10_3390_nu15051070 crossref_primary_10_1016_j_jmb_2024_168718 crossref_primary_10_1038_s41372_022_01376_8 crossref_primary_10_1016_j_jpeds_2024_114266 crossref_primary_10_3390_ijms21176424 crossref_primary_10_3390_app11167247 crossref_primary_10_3389_fmicb_2021_750635 crossref_primary_10_3389_fmicb_2023_1154114 crossref_primary_10_3390_microorganisms9102066 crossref_primary_10_1039_D3FO02092D crossref_primary_10_3390_ijms25041984 crossref_primary_10_1016_j_tim_2021_01_012 crossref_primary_10_3389_fimmu_2025_1575656 crossref_primary_10_3390_nu13031026 crossref_primary_10_7717_peerj_13325 crossref_primary_10_1016_j_foodhyd_2022_107697 crossref_primary_10_1016_j_neures_2020_11_006 crossref_primary_10_1016_j_jasrep_2025_105350 crossref_primary_10_3390_nu12041039 crossref_primary_10_3390_ijms231810476 crossref_primary_10_3390_life13020588 crossref_primary_10_1038_s41579_024_01068_4 crossref_primary_10_1038_s41577_020_00420_y crossref_primary_10_1016_j_nwh_2022_05_006 crossref_primary_10_3390_nu13031030 crossref_primary_10_3390_nu16223806 crossref_primary_10_1128_msystems_00243_22 crossref_primary_10_1038_s41598_020_66056_z crossref_primary_10_3390_ijms241411422 crossref_primary_10_1038_s41467_023_43279_y crossref_primary_10_1016_j_isci_2023_108311 crossref_primary_10_1186_s12934_021_01599_y crossref_primary_10_3389_fimmu_2021_628741 crossref_primary_10_3389_fimmu_2021_668569 crossref_primary_10_1016_j_microb_2025_100310 crossref_primary_10_1186_s40168_024_01852_7 crossref_primary_10_3389_fimmu_2024_1405344 crossref_primary_10_1186_s12929_019_0554_5 crossref_primary_10_1007_s40746_022_00252_z crossref_primary_10_3390_nu13041137 crossref_primary_10_1002_ueg2_12338 crossref_primary_10_3389_fnut_2022_1018153 crossref_primary_10_1111_imr_13411 crossref_primary_10_1038_s41598_023_50791_0 crossref_primary_10_1080_1040841X_2025_2480230 crossref_primary_10_3389_fmolb_2021_660456 crossref_primary_10_1111_imr_13376 crossref_primary_10_3390_medicina61061114 crossref_primary_10_1007_s10620_019_05648_w crossref_primary_10_1177_1535370219900898 crossref_primary_10_1016_j_fm_2022_104103 crossref_primary_10_1186_s40168_022_01230_1 crossref_primary_10_3389_fmicb_2021_664257 crossref_primary_10_3390_nu13051716 crossref_primary_10_3389_fimmu_2021_644269 crossref_primary_10_3389_fimmu_2020_01545 crossref_primary_10_3390_nu16152544 crossref_primary_10_3389_fvets_2020_00261 crossref_primary_10_3389_fimmu_2021_608372 crossref_primary_10_1186_s11658_022_00368_y crossref_primary_10_1016_j_chom_2024_08_014 crossref_primary_10_1016_j_postharvbio_2021_111572 crossref_primary_10_3390_cimb47080674 crossref_primary_10_3389_fimmu_2022_912529 crossref_primary_10_3390_antibiotics12111617 crossref_primary_10_3389_fimmu_2022_877771 crossref_primary_10_3390_nu13020606 crossref_primary_10_1007_s00281_019_00774_z crossref_primary_10_1017_S0007114521001197 crossref_primary_10_1128_spectrum_04967_22 crossref_primary_10_3389_fmicb_2020_00050 crossref_primary_10_1183_13993003_03997_2020 crossref_primary_10_3389_fmolb_2023_1204025 crossref_primary_10_3390_children11091113 crossref_primary_10_1016_j_nutres_2024_08_005 crossref_primary_10_1038_s44259_024_00030_x crossref_primary_10_1038_s41390_022_02350_y crossref_primary_10_1016_j_jpeds_2020_12_036 crossref_primary_10_1515_jom_2021_0069 crossref_primary_10_3390_nu12041105 crossref_primary_10_1097_TIN_0000000000000321 crossref_primary_10_1038_s41598_021_03779_7 crossref_primary_10_1016_j_tox_2024_153751 crossref_primary_10_3390_nu12061756 crossref_primary_10_1097_ACI_0000000000000629 crossref_primary_10_3390_biomedicines10020308 crossref_primary_10_3390_jcm9051483 crossref_primary_10_3390_biomedicines12112423 crossref_primary_10_1186_s12879_022_07107_w crossref_primary_10_1016_j_jff_2021_104719 crossref_primary_10_3390_foods13101438 crossref_primary_10_1007_s12088_022_01051_8 crossref_primary_10_1128_msystems_01132_21 crossref_primary_10_3390_children11081030 crossref_primary_10_1001_jamanetworkopen_2023_48230 crossref_primary_10_3390_nu16234122 crossref_primary_10_1038_s44321_024_00179_y crossref_primary_10_1093_femsec_fiae075 crossref_primary_10_3389_fmicb_2022_1006721 crossref_primary_10_3390_app15179590 crossref_primary_10_3390_microorganisms10010070 crossref_primary_10_1016_j_fbio_2024_103942 crossref_primary_10_1038_s41568_023_00584_4 crossref_primary_10_1111_apha_14092 crossref_primary_10_3389_fnut_2022_872217 crossref_primary_10_3389_fimmu_2021_645415 crossref_primary_10_1016_j_reval_2020_11_004 crossref_primary_10_1097_MS9_0000000000003099 crossref_primary_10_1093_advances_nmab122 crossref_primary_10_1515_jpm_2020_0131 crossref_primary_10_3390_nu17152396 crossref_primary_10_3390_pharmaceutics17060752 crossref_primary_10_1080_10408398_2020_1754756 crossref_primary_10_1016_j_jff_2020_104268 crossref_primary_10_3390_ijms23052804 crossref_primary_10_1371_journal_pone_0288689 crossref_primary_10_1016_j_jmii_2023_07_005 crossref_primary_10_1007_s00203_024_04104_2 crossref_primary_10_1177_1559827620912703 crossref_primary_10_3390_life15040593 crossref_primary_10_1016_j_csbj_2020_11_057 crossref_primary_10_3389_fimmu_2020_573629 crossref_primary_10_1007_s12519_021_00506_0 crossref_primary_10_3390_ani13213378 crossref_primary_10_1053_j_gastro_2020_01_024 crossref_primary_10_3390_nu13030724 crossref_primary_10_1016_j_ejogrb_2020_06_024 crossref_primary_10_1016_j_jnn_2021_08_003 crossref_primary_10_1080_1744666X_2023_2150612 crossref_primary_10_1016_j_jaci_2021_07_012 crossref_primary_10_1002_aur_3263 crossref_primary_10_1002_mnfr_202200066 crossref_primary_10_3390_metabo12020127 crossref_primary_10_1038_s41598_022_07904_y crossref_primary_10_1177_08903344211060343 crossref_primary_10_3389_fped_2023_1275436 crossref_primary_10_3389_fped_2023_1146089 crossref_primary_10_3390_nu15153447 crossref_primary_10_1186_s13213_020_01608_2 crossref_primary_10_2147_JAA_S334752 crossref_primary_10_1080_1040841X_2024_2342427 crossref_primary_10_1002_clt2_12356 crossref_primary_10_3390_jcm10030459 crossref_primary_10_3390_nu12113552 crossref_primary_10_3389_fimmu_2019_02866 crossref_primary_10_1111_mcn_13328 crossref_primary_10_1126_science_aay0618 crossref_primary_10_3390_nu15061535 crossref_primary_10_1097_JPN_0000000000000498 crossref_primary_10_1093_jn_nxaa310 crossref_primary_10_1080_10408398_2022_2136620 crossref_primary_10_1093_nutrit_nuac072 crossref_primary_10_1016_j_clnesp_2025_03_032 crossref_primary_10_3389_fcimb_2021_650893 crossref_primary_10_1002_mnfr_202200058 crossref_primary_10_3390_cancers13194947 crossref_primary_10_3390_pr9040569
Cites_doi	10.1093/glycob/cws074 10.1542/peds.2005-2824 10.1159/000071488 10.1007/s10534-014-9762-3 10.1016/j.jnutbio.2015.08.013 10.1128/IAI.00064-15 10.1016/j.jaci.2016.08.031 10.1371/journal.pone.0023031 10.4049/jimmunol.175.7.4490 10.3389/fnut.2017.00011 10.1084/jem.20180427 10.1111/all.13476 10.1067/mai.2001.111237 10.1016/j.jaci.2017.08.041 10.1136/gut.51.1.51 10.1017/S0954422410000065 10.1097/ACI.0000000000000303 10.7554/eLife.36521 10.1016/j.cell.2016.01.024 10.1038/nature09944 10.1039/C7FO00088J 10.1152/physrev.00045.2009 10.1002/emmm.201100159 10.4049/jimmunol.1601266 10.1016/j.chom.2015.05.012 10.15252/emmm.201404169 10.1136/gut.2006.100164 10.1034/j.1398-9995.2003.00264.x 10.1016/S0140-6736(15)01024-7 10.1126/science.1219328 10.1038/s41467-017-02573-2 10.1073/pnas.1412008111 10.1111/cea.12487 10.1126/science.aad9378 10.1002/bdrc.21113 10.3389/fimmu.2017.01822 10.1126/scitranslmed.aab2271 10.1016/j.cell.2013.11.042 10.1016/j.earlhumdev.2015.09.001 10.1038/nature12506 10.1038/s41586-018-0617-x 10.1016/j.chom.2018.05.003 10.1038/mi.2012.4 10.1016/j.chom.2016.04.025 10.1042/CS20160349 10.1016/j.imbio.2015.06.004 10.1016/S0264-410X(03)00338-4 10.1126/science.aad2571 10.1038/nm.4142 10.3389/fped.2017.00111 10.3390/nu10101355 10.1073/pnas.1000083107 10.3389/fimmu.2017.01374 10.1073/pnas.1315792111 10.1016/j.jaci.2018.02.032 10.1038/pr.2014.160 10.1038/nature12331 10.3945/ajcn.112.037382 10.1126/science.1223813 10.3389/fcimb.2018.00013 10.1111/pai.12874 10.1146/annurev-animal-022114-111112 10.1038/embor.2012.32 10.1371/journal.pone.0117038 10.1038/nm.4176 10.3390/microorganisms3040641 10.1038/srep40597 10.1038/ismej.2015.151 10.1016/j.cell.2016.05.056 10.1111/apa.13132 10.1038/nature08821 10.1542/peds.113.2.361 10.1093/jn/137.3.830S 10.4049/jimmunol.171.12.6680 10.1016/j.jaci.2017.11.019 10.4049/jimmunol.176.6.3742 10.1038/npjbiofilms.2016.14 10.1038/cti.2016.91 10.1073/pnas.1005963107 10.1016/j.jaci.2011.04.060 10.1128/IAI.69.6.3611-3617.2001 10.3389/fped.2018.00239 10.1084/jem.191.10.1807 10.1093/aje/kwu072 10.3390/nu9080817 10.1016/j.jaci.2016.06.047 10.1067/mpd.2001.117006 10.1038/nm.3444 10.1001/jamapediatrics.2018.1161 10.1038/srep23129 10.1128/AEM.00003-14 10.1016/j.chom.2013.10.004 10.1016/j.phrs.2012.09.001 10.1067/mai.2001.118130 10.1128/AEM.02599-07 10.1017/S2040174415001233 10.1016/j.imlet.2014.05.008 10.1038/nri.2016.42
ContentType	Journal Article
Copyright	Copyright © 2019 van den Elsen, Garssen, Burcelin and Verhasselt. 2019 van den Elsen, Garssen, Burcelin and Verhasselt
Copyright_xml	– notice: Copyright © 2019 van den Elsen, Garssen, Burcelin and Verhasselt. 2019 van den Elsen, Garssen, Burcelin and Verhasselt
DBID	AAYXX CITATION NPM 7X8 5PM DOA
DOI	10.3389/fped.2019.00047
DatabaseName	CrossRef PubMed MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals
DatabaseTitle	CrossRef PubMed MEDLINE - Academic
DatabaseTitleList	PubMed MEDLINE - Academic
Database_xml	– sequence: 1 dbid: DOA name: Directory of Open Access Journals (DOAJ) url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine
EISSN	2296-2360
ExternalDocumentID	oai_doaj_org_article_d88dae4e533e438480f2dca5c1857b58 PMC6400986 30873394 10_3389_fped_2019_00047
Genre	Journal Article Review
GroupedDBID	53G 5VS 9T4 AAFWJ AAYXX ACGFO ACGFS ADBBV ADRAZ AFPKN ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BCNDV CITATION DIK GROUPED_DOAJ GX1 HYE KQ8 M48 M~E OK1 PGMZT RNS RPM ACXDI EMOBN IAO IEA IHR IHW IPNFZ NPM RIG 7X8 5PM
ID	FETCH-LOGICAL-c525t-d33a98995c96f89d0480b78585c1e0954ce03a3ac0af27a1e881e286e3ba21443
IEDL.DBID	DOA
ISICitedReferencesCount	199
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000459812800002&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	2296-2360
IngestDate	Fri Oct 03 12:50:48 EDT 2025 Thu Aug 21 18:10:51 EDT 2025 Thu Oct 02 09:49:52 EDT 2025 Thu Jan 02 23:01:14 EST 2025 Sat Nov 29 02:51:30 EST 2025 Tue Nov 18 22:17:48 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Keywords	allergy neonate breastmilk gut microbiota prevention
Language	English
License	This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c525t-d33a98995c96f89d0480b78585c1e0954ce03a3ac0af27a1e881e286e3ba21443
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 This article was submitted to Pediatric Immunology, a section of the journal Frontiers in Pediatrics Reviewed by: Klaus Tenbrock, RWTH Aachen Universität, Germany; Beatriz Elena Marciano, National Institutes of Health (NIH), United States Edited by: George N. Konstantinou, 424 General Military Hospital, Greece
OpenAccessLink	https://doaj.org/article/d88dae4e533e438480f2dca5c1857b58
PMID	30873394
PQID	2193171056
PQPubID	23479
ParticipantIDs	doaj_primary_oai_doaj_org_article_d88dae4e533e438480f2dca5c1857b58 pubmedcentral_primary_oai_pubmedcentral_nih_gov_6400986 proquest_miscellaneous_2193171056 pubmed_primary_30873394 crossref_primary_10_3389_fped_2019_00047 crossref_citationtrail_10_3389_fped_2019_00047
PublicationCentury	2000
PublicationDate	2019-02-27
PublicationDateYYYYMMDD	2019-02-27
PublicationDate_xml	– month: 02 year: 2019 text: 2019-02-27 day: 27
PublicationDecade	2010
PublicationPlace	Switzerland
PublicationPlace_xml	– name: Switzerland
PublicationTitle	Frontiers in pediatrics
PublicationTitleAlternate	Front Pediatr
PublicationYear	2019
Publisher	Frontiers Media S.A
Publisher_xml	– name: Frontiers Media S.A
References	Charbonneau (B26) 2016; 164 Amenyogbe (B54) 2017; 5 Rogier (B82) 2014; 111 Victora (B10) 2016; 387 Rooks (B25) 2016; 16 Arumugam (B23) 2011; 473 Le (B63) 2010; 23 Jiang (B83) 2001; 69 Collado (B61) 2016; 6 Penders (B36) 2006; 118 van Odijk (B6) 2003; 58 Azad (B20) 2015; 45 An (B43) 2014; 156 Iraporda (B57) 2015; 220 Thio (B60) 2018; 142 Bode (B72) 2015; 91 Renz (B13) 2018; 141 Ramsay (B70) 2004; 113 Munblit (B12) 2016; 16 Arrieta (B30) 2018; 142 Walker (B89) 2015; 77 Kalliomaki (B34) 2001; 107 Kirjavainen (B37) 2002; 51 Ling (B28) 2014; 80 Johansson (B19) 2011; 6 Brandtzaeg (B81) 2003; 21 Backhed (B22) 2015; 17 Denou (B50) 2015; 7 Jimenez (B99) 2008; 74 Trompette (B59) 2014; 20 LeBouder (B94) 2003; 171 Coats (B48) 2005; 175 Gomez-Gallego (B90) 2018; 10 Pacheco (B78) 2015; 3 Fujimura (B31) 2016; 22 Roberfroid (B71) 2007; 137 Ojeda (B96) 2016; 28 Rautava (B64) 2016; 7 Gomez de Aguero (B91) 2016; 351 Arrieta (B17) 2015; 7 Dogaru (B9) 2014; 179 Cahenzli (B14) 2013; 14 Wickens (B98) 2018; 29 Vatanen (B32) 2016; 165 van Best (B2) 2015; 105 Bisgaard (B18) 2011; 128 Trend (B88) 2015; 10 Sekirov (B5) 2010; 90 Gao (B47) 2018; 8 Van der Leek (B45) 2017; 8 Ayechu-Muruzabal (B75) 2018; 6 Ip (B8) 2007 Murphy (B68) 2017; 7 Labeta (B93) 2000; 191 Jiang (B97) 2018; 9 Pirr (B87) 2017; 8 Russell (B16) 2012; 13 Stiemsma (B29) 2016; 130 Martinez (B3) 2018; 7 Stokholm (B39) 2018; 9 Miliku (B77) 2018; 73 Agus (B46) 2018; 23 Lodge (B11) 2015; 104 Pabst (B40) 2012; 5 Demmelmair (B79) 2017; 9 Berni Canani (B27) 2016; 10 Lodinova-Zadnikova (B38) 2003; 131 Cabrera-Rubio (B69) 2012; 96 Qin (B24) 2010; 464 Amar (B51) 2011; 3 LeBouder (B95) 2006; 176 Nakajima (B85) 2018; 215 Stewart (B62) 2018; 562 Gdalevich (B7) 2001; 139 Gensollen (B1) 2016; 352 Seppo (B76) 2017; 139 Plunkett (B52) 2017; 198 Fernandez (B67) 2013; 69 Mastromarino (B86) 2014; 27 Secher (B41) 2015; 83 Feehley (B49) 2016; 19 Kaetzel (B80) 2014; 162 Zivkovic (B74) 2011; 108 Penders (B35) 2007; 56 van den Elsen (B58) 2017; 6 Stefka (B44) 2014; 111 Baars (B55) 2015; 3 Le Chatelier (B21) 2013; 500 Bjorksten (B33) 2001; 108 Bridgman (B56) 2017; 4 Forbes (B65) 2018; 172 Tamburini (B4) 2016; 22 Nicholson (B53) 2012; 336 Olszak (B15) 2012; 336 De Filippo (B66) 2010; 107 Atarashi (B42) 2013; 500 Dzidic (B84) 2017; 139 Korecka (B92) 2016; 2 Bode (B73) 2012; 22
References_xml	– volume: 22 start-page: 1147 year: 2012 ident: B73 article-title: Human milk oligosaccharides: every baby needs a sugar mama publication-title: Glycobiology doi: 10.1093/glycob/cws074 – volume: 118 start-page: 511 year: 2006 ident: B36 article-title: Factors influencing the composition of the intestinal microbiota in early infancy publication-title: Pediatrics doi: 10.1542/peds.2005-2824 – volume: 131 start-page: 209 year: 2003 ident: B38 article-title: Oral administration of probiotic Escherichia coli after birth reduces frequency of allergies and repeated infections later in life (after 10 and 20 years) publication-title: Int Arch Allergy Immunol. doi: 10.1159/000071488 – volume: 27 start-page: 1077 year: 2014 ident: B86 article-title: Correlation between lactoferrin and beneficial microbiota in breast milk and infant's feces publication-title: Biometals doi: 10.1007/s10534-014-9762-3 – volume: 28 start-page: 191 year: 2016 ident: B96 article-title: Nutritional modulation of gut microbiota - the impact on metabolic disease pathophysiology publication-title: J Nutr Biochem. doi: 10.1016/j.jnutbio.2015.08.013 – volume: 83 start-page: 2420 year: 2015 ident: B41 article-title: Oral tolerance failure upon neonatal gut colonization with Escherichia coli producing the genotoxin colibactin publication-title: Infect Immun. doi: 10.1128/IAI.00064-15 – volume: 139 start-page: 708 year: 2017 ident: B76 article-title: Human milk oligosaccharides and development of cow's milk allergy in infants publication-title: J Allergy Clin Immunol. doi: 10.1016/j.jaci.2016.08.031 – volume: 6 start-page: e23031 year: 2011 ident: B19 article-title: Early colonization with a group of Lactobacilli decreases the risk for allergy at five years of age despite allergic heredity publication-title: PLoS ONE doi: 10.1371/journal.pone.0023031 – volume: 175 start-page: 4490 year: 2005 ident: B48 article-title: MD-2 mediates the ability of tetra-acylated and penta-acylated lipopolysaccharides to antagonize Escherichia coli lipopolysaccharide at the TLR4 signaling complex publication-title: J Immunol doi: 10.4049/jimmunol.175.7.4490 – volume: 4 start-page: 11 year: 2017 ident: B56 article-title: Fecal short-chain fatty acid variations by breastfeeding status in infants at 4 months: differences in relative versus absolute concentrations publication-title: Front Nutr. doi: 10.3389/fnut.2017.00011 – volume: 215 start-page: 2019 year: 2018 ident: B85 article-title: IgA regulates the composition and metabolic function of gut microbiota by promoting symbiosis between bacteria publication-title: J Exp Med. doi: 10.1084/jem.20180427 – volume: 73 start-page: 2070 year: 2018 ident: B77 article-title: Human milk oligosaccharide profiles and food sensitization among infants in the CHILD Study publication-title: Allergy doi: 10.1111/all.13476 – volume: 107 start-page: 129 year: 2001 ident: B34 article-title: Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing publication-title: J Allergy Clin Immunol. doi: 10.1067/mai.2001.111237 – volume: 142 start-page: 424 year: 2018 ident: B30 article-title: Associations between infant fungal and bacterial dysbiosis and childhood atopic wheeze in a nonindustrialized setting publication-title: J Allergy Clin Immunol. doi: 10.1016/j.jaci.2017.08.041 – volume: 51 start-page: 51 year: 2002 ident: B37 article-title: Aberrant composition of gut microbiota of allergic infants: a target of bifidobacterial therapy at weaning? publication-title: Gut doi: 10.1136/gut.51.1.51 – volume: 23 start-page: 23 year: 2010 ident: B63 article-title: Breast- v. formula-feeding: impacts on the digestive tract and immediate and long-term health effects publication-title: Nutr Res Rev doi: 10.1017/S0954422410000065 – volume: 16 start-page: 427 year: 2016 ident: B12 article-title: Allergy prevention by breastfeeding: possible mechanisms and evidence from human cohorts publication-title: Curr Opin Allergy Clin Immunol. doi: 10.1097/ACI.0000000000000303 – volume: 7 start-page: e36521 year: 2018 ident: B3 article-title: Experimental evaluation of the importance of colonization history in early-life gut microbiota assembly publication-title: Elife doi: 10.7554/eLife.36521 – volume: 164 start-page: 859 year: 2016 ident: B26 article-title: Sialylated milk oligosaccharides promote microbiota-dependent growth in models of infant undernutrition publication-title: Cell doi: 10.1016/j.cell.2016.01.024 – volume: 473 start-page: 174 year: 2011 ident: B23 article-title: Enterotypes of the human gut microbiome publication-title: Nature doi: 10.1038/nature09944 – volume: 9 start-page: 1028 year: 2018 ident: B97 article-title: Association between sn-2 fatty acid profiles of breast milk and development of the infant intestinal microbiome publication-title: Food Funct doi: 10.1039/C7FO00088J – volume: 90 start-page: 859 year: 2010 ident: B5 article-title: Gut microbiota in health and disease publication-title: Physiol Rev. doi: 10.1152/physrev.00045.2009 – volume: 3 start-page: 559 year: 2011 ident: B51 article-title: Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment publication-title: EMBO Mol Med. doi: 10.1002/emmm.201100159 – volume: 198 start-page: 581 year: 2017 ident: B52 article-title: The influence of the microbiome on allergic sensitization to food publication-title: J Immunol doi: 10.4049/jimmunol.1601266 – volume: 17 start-page: 852 year: 2015 ident: B22 article-title: Dynamics and stabilization of the human gut microbiome during the first year of life publication-title: Cell Host Microbe doi: 10.1016/j.chom.2015.05.012 – volume: 7 start-page: 259 year: 2015 ident: B50 article-title: Defective NOD2 peptidoglycan sensing promotes diet-induced inflammation, dysbiosis, and insulin resistance publication-title: EMBO Mol Med. doi: 10.15252/emmm.201404169 – volume: 56 start-page: 661 year: 2007 ident: B35 article-title: Gut microbiota composition and development of atopic manifestations in infancy: the KOALA Birth Cohort Study publication-title: Gut doi: 10.1136/gut.2006.100164 – volume: 58 start-page: 833 year: 2003 ident: B6 article-title: Breastfeeding and allergic disease: a multidisciplinary review of the literature (1966–2001) on the mode of early feeding in infancy and its impact on later atopic manifestations publication-title: Allergy doi: 10.1034/j.1398-9995.2003.00264.x – volume: 387 start-page: 475 year: 2016 ident: B10 article-title: Breastfeeding in the 21st century: epidemiology, mechanisms, and lifelong effect publication-title: Lancet doi: 10.1016/S0140-6736(15)01024-7 – volume: 336 start-page: 489 year: 2012 ident: B15 article-title: Microbial exposure during early life has persistent effects on natural killer T cell function publication-title: Science doi: 10.1126/science.1219328 – volume: 9 start-page: 141 year: 2018 ident: B39 article-title: Maturation of the gut microbiome and risk of asthma in childhood publication-title: Nat Commun. doi: 10.1038/s41467-017-02573-2 – volume: 111 start-page: 13145 year: 2014 ident: B44 article-title: Commensal bacteria protect against food allergen sensitization publication-title: Proc Nat Acad Sci USA. doi: 10.1073/pnas.1412008111 – volume: 45 start-page: 632 year: 2015 ident: B20 article-title: Infant gut microbiota and food sensitization: associations in the first year of life publication-title: Clin Exp Allergy doi: 10.1111/cea.12487 – volume: 352 start-page: 539 year: 2016 ident: B1 article-title: How colonization by microbiota in early life shapes the immune system publication-title: Science doi: 10.1126/science.aad9378 – volume: 105 start-page: 240 year: 2015 ident: B2 article-title: On the origin of species: factors shaping the establishment of infant's gut microbiota publication-title: Birth Defects Res C Embryo Today doi: 10.1002/bdrc.21113 – volume: 8 start-page: 1822 year: 2017 ident: B87 article-title: High amounts of S100-alarmins confer antimicrobial activity on human breast milk targeting pathogens relevant in neonatal sepsis publication-title: Front Immunol. doi: 10.3389/fimmu.2017.01822 – volume: 7 start-page: 307ra152 year: 2015 ident: B17 article-title: Early infancy microbial and metabolic alterations affect risk of childhood asthma publication-title: Sci Transl Med. doi: 10.1126/scitranslmed.aab2271 – volume: 156 start-page: 123 year: 2014 ident: B43 article-title: Sphingolipids from a symbiotic microbe regulate homeostasis of host intestinal natural killer T cells publication-title: Cell doi: 10.1016/j.cell.2013.11.042 – volume: 91 start-page: 619 year: 2015 ident: B72 article-title: The functional biology of human milk oligosaccharides publication-title: Early Hum Dev. doi: 10.1016/j.earlhumdev.2015.09.001 – volume: 500 start-page: 541 year: 2013 ident: B21 article-title: Richness of human gut microbiome correlates with metabolic markers publication-title: Nature doi: 10.1038/nature12506 – volume: 562 start-page: 583 year: 2018 ident: B62 article-title: Temporal development of the gut microbiome in early childhood from the TEDDY study publication-title: Nature doi: 10.1038/s41586-018-0617-x – volume: 23 start-page: 716 year: 2018 ident: B46 article-title: Gut microbiota regulation of tryptophan metabolism in health and disease publication-title: Cell Host Microbe doi: 10.1016/j.chom.2018.05.003 – volume: 5 start-page: 232 year: 2012 ident: B40 article-title: Oral tolerance to food protein publication-title: Mucosal Immunol. doi: 10.1038/mi.2012.4 – volume: 19 start-page: 572 year: 2016 ident: B49 article-title: What's LPS got to do with it? a role for gut LPS variants in driving autoimmune and allergic disease publication-title: Cell Host Microbe doi: 10.1016/j.chom.2016.04.025 – volume: 130 start-page: 2199 year: 2016 ident: B29 article-title: Shifts in Lachnospira and Clostridium sp publication-title: Clin Sci. doi: 10.1042/CS20160349 – volume: 220 start-page: 1161 year: 2015 ident: B57 article-title: Lactate and short chain fatty acids produced by microbial fermentation downregulate proinflammatory responses in intestinal epithelial cells and myeloid cells publication-title: Immunobiology doi: 10.1016/j.imbio.2015.06.004 – volume: 21 start-page: 3382 year: 2003 ident: B81 article-title: Mucosal immunity: integration between mother and the breast-fed infant publication-title: Vaccine doi: 10.1016/S0264-410X(03)00338-4 – volume: 351 start-page: 1296 year: 2016 ident: B91 article-title: The maternal microbiota drives early postnatal innate immune development publication-title: Science doi: 10.1126/science.aad2571 – volume: 22 start-page: 713 year: 2016 ident: B4 article-title: The microbiome in early life: implications for health outcomes publication-title: Nat Med. doi: 10.1038/nm.4142 – volume: 5 start-page: 111 year: 2017 ident: B54 article-title: Early-life host-microbiome interphase: the key frontier for immune development publication-title: Front Pediatr doi: 10.3389/fped.2017.00111 – volume: 10 start-page: E1355 year: 2018 ident: B90 article-title: Human breast milk NMR metabolomic profile across specific geographical locations and its association with the milk microbiota publication-title: Nutrients doi: 10.3390/nu10101355 – volume: 108 start-page: 4653 year: 2011 ident: B74 article-title: Human milk glycobiome and its impact on the infant gastrointestinal microbiota publication-title: Proc Nat Acad Sci USA. doi: 10.1073/pnas.1000083107 – volume: 8 start-page: 1374 year: 2017 ident: B45 article-title: The kynurenine pathway as a novel link between allergy and the gut microbiome publication-title: Front Immunol. doi: 10.3389/fimmu.2017.01374 – volume: 111 start-page: 3074 year: 2014 ident: B82 article-title: Secretory antibodies in breast milk promote long-term intestinal homeostasis by regulating the gut microbiota and host gene expression publication-title: Proc Nat Acad Sci USA. doi: 10.1073/pnas.1315792111 – volume: 142 start-page: 1867 year: 2018 ident: B60 article-title: Regulation of type 2 innate lymphoid cell-dependent airway hyperreactivity by butyrate publication-title: J Allergy Clin Immunol. doi: 10.1016/j.jaci.2018.02.032 – volume: 77 start-page: 220 year: 2015 ident: B89 article-title: Breast milk, microbiota, and intestinal immune homeostasis publication-title: Pediatr Res. doi: 10.1038/pr.2014.160 – volume: 500 start-page: 232 year: 2013 ident: B42 article-title: Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota publication-title: Nature doi: 10.1038/nature12331 – volume: 96 start-page: 544 year: 2012 ident: B69 article-title: The human milk microbiome changes over lactation and is shaped by maternal weight and mode of delivery publication-title: Am J Clin. Nutr. doi: 10.3945/ajcn.112.037382 – volume: 336 start-page: 1262 year: 2012 ident: B53 article-title: Host-gut microbiota metabolic interactions publication-title: Science doi: 10.1126/science.1223813 – volume: 8 start-page: 13 year: 2018 ident: B47 article-title: Impact of the gut microbiota on intestinal immunity mediated by tryptophan metabolism publication-title: Front Cell Infect Microbiol doi: 10.3389/fcimb.2018.00013 – volume: 29 start-page: 296 year: 2018 ident: B98 article-title: Maternal supplementation alone with Lactobacillus rhamnosus HN001 during pregnancy and breastfeeding does not reduce infant eczema publication-title: Pediatr Allergy Immunol doi: 10.1111/pai.12874 – volume: 3 start-page: 419 year: 2015 ident: B78 article-title: The impact of the milk glycobiome on the neonate gut microbiota publication-title: Annu Rev Anim Biosci doi: 10.1146/annurev-animal-022114-111112 – volume: 13 start-page: 440 year: 2012 ident: B16 article-title: Early life antibiotic-driven changes in microbiota enhance susceptibility to allergic asthma publication-title: EMBO Rep doi: 10.1038/embor.2012.32 – volume: 10 start-page: e0117038 year: 2015 ident: B88 article-title: Antimicrobial protein and Peptide concentrations and activity in human breast milk consumed by preterm infants at risk of late-onset neonatal sepsis publication-title: PLoS One doi: 10.1371/journal.pone.0117038 – volume: 22 start-page: 1187 year: 2016 ident: B31 article-title: Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation publication-title: Nat Med. doi: 10.1038/nm.4176 – volume: 3 start-page: 641 year: 2015 ident: B55 article-title: The gut microbiota as a therapeutic target in IBD and metabolic disease: a role for the bile acid receptors FXR and TGR5 publication-title: Microorganisms doi: 10.3390/microorganisms3040641 – volume: 7 start-page: 40597 year: 2017 ident: B68 article-title: The composition of human milk and infant faecal microbiota over the first three months of life: a pilot study publication-title: Sci Rep. doi: 10.1038/srep40597 – volume: 10 start-page: 742 year: 2016 ident: B27 article-title: Lactobacillus rhamnosus GG-supplemented formula expands butyrate-producing bacterial strains in food allergic infants publication-title: ISME J doi: 10.1038/ismej.2015.151 – volume: 165 start-page: 1551 year: 2016 ident: B32 article-title: Variation in microbiome LPS immunogenicity contributes to autoimmunity in humans publication-title: Cell doi: 10.1016/j.cell.2016.05.056 – volume: 104 start-page: 38 year: 2015 ident: B11 article-title: Breastfeeding and asthma and allergies: a systematic review and meta-analysis publication-title: Acta Paediatr. doi: 10.1111/apa.13132 – volume: 464 start-page: 59 year: 2010 ident: B24 article-title: A human gut microbial gene catalogue established by metagenomic sequencing publication-title: Nature doi: 10.1038/nature08821 – volume: 113 start-page: 361 year: 2004 ident: B70 article-title: Ultrasound imaging of milk ejection in the breast of lactating women publication-title: Pediatrics doi: 10.1542/peds.113.2.361 – volume: 137 start-page: 830S year: 2007 ident: B71 article-title: Prebiotics: the concept revisited publication-title: J Nutr. doi: 10.1093/jn/137.3.830S – volume: 171 start-page: 6680 year: 2003 ident: B94 article-title: Soluble forms of Toll-like receptor (TLR)2 capable of modulating TLR2 signaling are present in human plasma and breast milk publication-title: J Immunol doi: 10.4049/jimmunol.171.12.6680 – volume: 141 start-page: 1212 year: 2018 ident: B13 article-title: The neonatal window of opportunity-early priming for life publication-title: J Allergy Clin Immunol. doi: 10.1016/j.jaci.2017.11.019 – volume: 176 start-page: 3742 year: 2006 ident: B95 article-title: Modulation of neonatal microbial recognition: TLR-mediated innate immune responses are specifically and differentially modulated by human milk publication-title: J Immunol doi: 10.4049/jimmunol.176.6.3742 – volume: 2 start-page: 16014 year: 2016 ident: B92 article-title: Bidirectional communication between the Aryl hydrocarbon receptor (AhR) and the microbiome tunes host metabolism publication-title: NPJ Biofilms Microbiomes doi: 10.1038/npjbiofilms.2016.14 – volume: 6 start-page: e125 year: 2017 ident: B58 article-title: Embracing the gut microbiota: the new frontier for inflammatory and infectious diseases publication-title: Clin Transl Immunol. doi: 10.1038/cti.2016.91 – volume: 107 start-page: 14691 year: 2010 ident: B66 article-title: Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa publication-title: Proc Nat Acad Sci USA. doi: 10.1073/pnas.1005963107 – volume: 128 start-page: 646 year: 2011 ident: B18 article-title: Reduced diversity of the intestinal microbiota during infancy is associated with increased risk of allergic disease at school age publication-title: J Allergy Clin Immunol. doi: 10.1016/j.jaci.2011.04.060 – volume: 69 start-page: 3611 year: 2001 ident: B83 article-title: Timing, localization, and persistence of colonization by segmented filamentous bacteria in the neonatal mouse gut depend on immune status of mothers and pups publication-title: Infect Immun. doi: 10.1128/IAI.69.6.3611-3617.2001 – volume: 6 start-page: 239 year: 2018 ident: B75 article-title: Diversity of human milk oligosaccharides and effects on early life immune development publication-title: Front Pediatr. doi: 10.3389/fped.2018.00239 – volume: 191 start-page: 1807 year: 2000 ident: B93 article-title: Innate recognition of bacteria in human milk is mediated by a milk-derived highly expressed pattern recognition receptor, soluble CD14 publication-title: J Exp Med. doi: 10.1084/jem.191.10.1807 – volume: 179 start-page: 1153 year: 2014 ident: B9 article-title: Breastfeeding and childhood asthma: systematic review and meta-analysis publication-title: Am J Epidemiol. doi: 10.1093/aje/kwu072 – volume: 9 start-page: E817 year: 2017 ident: B79 article-title: Benefits of lactoferrin, osteopontin and milk fat globule membranes for infants publication-title: Nutrients doi: 10.3390/nu9080817 – volume: 139 start-page: 1017 year: 2017 ident: B84 article-title: Aberrant IgA responses to the gut microbiota during infancy precede asthma and allergy development publication-title: J Allergy Clin Immunol. doi: 10.1016/j.jaci.2016.06.047 – volume: 139 start-page: 261 year: 2001 ident: B7 article-title: Breast-feeding and the risk of bronchial asthma in childhood: a systematic review with meta-analysis of prospective studies publication-title: J Pediatr. doi: 10.1067/mpd.2001.117006 – volume: 20 start-page: 159 year: 2014 ident: B59 article-title: Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis publication-title: Nature medicine doi: 10.1038/nm.3444 – volume: 172 start-page: e181161 year: 2018 ident: B65 article-title: Association of exposure to formula in the hospital and subsequent infant feeding practices with gut microbiota and risk of overweight in the first year of life publication-title: JAMA Pediatr doi: 10.1001/jamapediatrics.2018.1161 – volume: 6 start-page: 23129 year: 2016 ident: B61 article-title: Human gut colonisation may be initiated in utero by distinct microbial communities in the placenta and amniotic fluid publication-title: Sci Rep. doi: 10.1038/srep23129 – volume: 80 start-page: 2546 year: 2014 ident: B28 article-title: Altered fecal microbiota composition associated with food allergy in infants publication-title: Appl Environ Microbiol. doi: 10.1128/AEM.00003-14 – volume: 14 start-page: 559 year: 2013 ident: B14 article-title: Intestinal microbial diversity during early-life colonization shapes long-term IgE levels publication-title: Cell Host Microbe doi: 10.1016/j.chom.2013.10.004 – volume: 69 start-page: 1 year: 2013 ident: B67 article-title: The human milk microbiota: origin and potential roles in health and disease publication-title: Pharmacol Res doi: 10.1016/j.phrs.2012.09.001 – start-page: 1 year: 2007 ident: B8 article-title: Breastfeeding and maternal and infant health outcomes in developed countries publication-title: Evid Rep Technol Assess – volume: 108 start-page: 516 year: 2001 ident: B33 article-title: Allergy development and the intestinal microflora during the first year of life publication-title: J Allergy Clin Immunol. doi: 10.1067/mai.2001.118130 – volume: 74 start-page: 4650 year: 2008 ident: B99 article-title: Oral administration of Lactobacillus strains isolated from breast milk as an alternative for the treatment of infectious mastitis during lactation publication-title: Appl Environ. Microbiol. doi: 10.1128/AEM.02599-07 – volume: 7 start-page: 5 year: 2016 ident: B64 article-title: Early microbial contact, the breast milk microbiome and child health publication-title: J Dev Orig Health Dis doi: 10.1017/S2040174415001233 – volume: 162 start-page: 10 year: 2014 ident: B80 article-title: Cooperativity among secretory IgA, the polymeric immunoglobulin receptor, and the gut microbiota promotes host-microbial mutualism publication-title: Immunol Lett. doi: 10.1016/j.imlet.2014.05.008 – volume: 16 start-page: 341 year: 2016 ident: B25 article-title: Gut microbiota, metabolites and host immunity publication-title: Nat Rev Immunol. doi: 10.1038/nri.2016.42
SSID	ssj0000970515
Score	2.5259182
SecondaryResourceType	review_article
Snippet	Evidence is accumulating that demonstrates the importance of the gut microbiota in health and diseases such as allergy. Recent studies emphasize the importance...
SourceID	doaj pubmedcentral proquest pubmed crossref
SourceType	Open Website Open Access Repository Aggregation Database Index Database Enrichment Source
StartPage	47
SubjectTerms	allergy breastmilk gut microbiota neonate Pediatrics prevention
Title	Shaping the Gut Microbiota by Breastfeeding: The Gateway to Allergy Prevention?
URI	https://www.ncbi.nlm.nih.gov/pubmed/30873394 https://www.proquest.com/docview/2193171056 https://pubmed.ncbi.nlm.nih.gov/PMC6400986 https://doaj.org/article/d88dae4e533e438480f2dca5c1857b58
Volume	7
WOSCitedRecordID	wos000459812800002&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAON databaseName: Directory of Open Access Journals (DOAJ) customDbUrl: eissn: 2296-2360 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000970515 issn: 2296-2360 databaseCode: DOA dateStart: 20130101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2296-2360 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000970515 issn: 2296-2360 databaseCode: M~E dateStart: 20130101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrZ3Pb9MwFMefYEKIy8RvMsZkJA5cwprajm1u27TBgQ4khtSb5TjPWyWUTls6aZf97fjZadUiEBcuPaSOYj07ft8X-30ewDvfuiq0I1VK4bEUdRNKxxFLp3SjvAjCuITM_6JOT_V0ar6tlfqiM2EZD5wNt99q3ToUGGUJCq6FHoVx6530BDFqZErzjapnLZhKa7BRVLwks3xiFGb2wyUSGLQyic-pNtxQovX_SWL-flJyzfWcPIbtQTOyg9zXJ3APu6fwcDLsij-Dr98vHKU9sSjm2KdFzyazjFfqHWtu2SGdO-9DdlMf2Rk1yt_MWD9nB5QLeH7LliynKL-fw4-T47Ojz-VQKKH0ciz7suXcmRg4SW_qoE1LeeKNoh0_X2HUUIKKgjnu_MiFsXIVal3hWNfIG0fINP4Ctrp5h6-AiVqiMBWquBKIEIKJPr4x3NVRyUk0soAPS7tZP1DEqZjFTxujCTK0JUNbMrRNhi7g_eqGywzQ-HvTQxqIVTMiX6cLcT7YYT7Yf82HAt4uh9HGN4W2P1yH88W1jWtzFEtRT9YFvMzDunoUcRE5N6IAtTHgG33Z_KebXSQady2IyVrv_I_Ov4ZHZI6UMq92Yau_WuAbeOBv-tn11R7cV1O9lyZ6_J3cHf8CbcgDBw
linkProvider	Directory of Open Access Journals
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Shaping+the+Gut+Microbiota+by+Breastfeeding%3A+The+Gateway+to+Allergy+Prevention%3F&rft.jtitle=Frontiers+in+pediatrics&rft.au=van+den+Elsen%2C+Lieke+W+J&rft.au=Garssen%2C+Johan&rft.au=Burcelin%2C+Remy&rft.au=Verhasselt%2C+Valerie&rft.date=2019-02-27&rft.issn=2296-2360&rft.eissn=2296-2360&rft.volume=7&rft.spage=47&rft_id=info:doi/10.3389%2Ffped.2019.00047&rft.externalDBID=NO_FULL_TEXT
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2296-2360&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2296-2360&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2296-2360&client=summon