In vitro and in vivo characterization of anthrax anti-protective antigen and anti-lethal factor monoclonal antibodies after passive transfer in a mouse lethal toxin challenge model to define correlates of immunity

Passive transfer of antibody may be useful for preexposure prophylaxis against biological agents used as weapons of terror, such as Bacillus anthracis. Studies were performed to evaluate the ability of anthrax antiprotective antigen (anti-PA) and antilethal factor (anti-LF) neutralizing monoclonal a...

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Bibliographic Details
Published in:	Infection and immunity Vol. 75; no. 11; p. 5443
Main Authors:	Staats, Herman F, Alam, S Munir, Scearce, Richard M, Kirwan, Shaun M, Zhang, Julia Xianzhi, Gwinn, William M, Haynes, Barton F
Format:	Journal Article
Language:	English
Published:	United States 01.11.2007
Subjects:	Animals Anthrax - immunology Anthrax - prevention & control Antibodies, Bacterial - immunology Antibodies, Monoclonal - immunology Antibody Affinity Antigens, Bacterial - immunology Antigens, Bacterial - toxicity Antitoxins - immunology Bacillus anthracis - immunology Bacterial Toxins - immunology Bacterial Toxins - toxicity Cell Line Cell Survival Female Immunization, Passive Macrophages - drug effects Mice Mice, Inbred BALB C Neutralization Tests
ISSN:	0019-9567
Online Access:	Get more information
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