Antigen-Independent IFN-γ Production by Human Naïve CD4+ T Cells Activated by IL-12 Plus IL-18

The role of T cells in innate immunity is not well defined. In this report, we show that a subset of human peripheral blood CD4(+) T cells responds to IL-12 plus IL-18, but not to IL-12 or IL-18 alone, by producing IFN-γ in the absence of any antigenic stimulation or cell proliferation. Intracellula...

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Bibliographic Details
Published in:	PloS one Vol. 6; no. 5; p. e18553
Main Authors:	Munk, Rachel B., Sugiyama, Katsuki, Ghosh, Paritosh, Sasaki, Carl Y., Rezanka, Louis, Banerjee, Kasturi, Takahashi, Hidenori, Sen, Ranjan, Longo, Dan L.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 10.05.2011 Public Library of Science (PLoS)
Subjects:	Adaptive immunity Animals Antigens Antigens, Differentiation - metabolism Biology CD4 antigen CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - metabolism CD45RA antigen Cell proliferation Cells, Cultured Humans Imidazoles - pharmacology Immune response Immunity Innate immunity Interferon Interferon-gamma - genetics Interferon-gamma - metabolism Interleukin 12 Interleukin 18 Interleukin-12 - pharmacology Interleukin-18 - pharmacology Intracellular Signaling Peptides and Proteins - metabolism Kinases Laboratories Listeria monocytogenes Lymphocytes Lymphocytes T Male MAP kinase Mice NF-κB protein p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors p38 Mitogen-Activated Protein Kinases - metabolism Peripheral blood Phosphorylation - drug effects Polymerase Chain Reaction Pyridines - pharmacology Rapamycin Sirolimus - pharmacology STAT4 Transcription Factor - metabolism Stimulation T cell receptors TOR protein TOR Serine-Threonine Kinases - antagonists & inhibitors TOR Serine-Threonine Kinases - metabolism Transcription γ-Interferon United States > US Maryland Baltimore Maryland
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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