Parkinson's disease-related LRRK2 G2019S mutation results from independent mutational events in humans

Mutations in the leucine-rich-repeat kinase 2 (LRRK2) gene have been identified in families with autosomal dominant Parkinson's disease (PD) and in sporadic cases; the G2019S mutation is the single most frequent. Intriguingly, the frequency of this mutation in PD patients varies greatly among e...

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Vydané v:	Human molecular genetics Ročník 19; číslo 10; s. 1998
Hlavní autori:	Lesage, Suzanne, Patin, Etienne, Condroyer, Christel, Leutenegger, Anne-Louise, Lohmann, Ebba, Giladi, Nir, Bar-Shira, Anat, Belarbi, Soraya, Hecham, Nassima, Pollak, Pierre, Ouvrard-Hernandez, Anne-Marie, Bardien, Soraya, Carr, Jonathan, Benhassine, Traki, Tomiyama, Hiroyuki, Pirkevi, Caroline, Hamadouche, Tarik, Cazeneuve, Cécile, Basak, A Nazli, Hattori, Nobutaka, Dürr, Alexandra, Tazir, Meriem, Orr-Urtreger, Avi, Quintana-Murci, Lluis, Brice, Alexis
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England 15.05.2010
Predmet:	Amino Acid Substitution - genetics Ethnic Groups - genetics Evolution, Molecular Haplotypes - genetics Humans Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Mutation - genetics Parkinson Disease - genetics Protein-Serine-Threonine Kinases - genetics
ISSN:	1460-2083, 1460-2083
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