Parkinson's disease-related LRRK2 G2019S mutation results from independent mutational events in humans

Mutations in the leucine-rich-repeat kinase 2 (LRRK2) gene have been identified in families with autosomal dominant Parkinson's disease (PD) and in sporadic cases; the G2019S mutation is the single most frequent. Intriguingly, the frequency of this mutation in PD patients varies greatly among e...

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Veröffentlicht in:	Human molecular genetics Jg. 19; H. 10; S. 1998
Hauptverfasser:	Lesage, Suzanne, Patin, Etienne, Condroyer, Christel, Leutenegger, Anne-Louise, Lohmann, Ebba, Giladi, Nir, Bar-Shira, Anat, Belarbi, Soraya, Hecham, Nassima, Pollak, Pierre, Ouvrard-Hernandez, Anne-Marie, Bardien, Soraya, Carr, Jonathan, Benhassine, Traki, Tomiyama, Hiroyuki, Pirkevi, Caroline, Hamadouche, Tarik, Cazeneuve, Cécile, Basak, A Nazli, Hattori, Nobutaka, Dürr, Alexandra, Tazir, Meriem, Orr-Urtreger, Avi, Quintana-Murci, Lluis, Brice, Alexis
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England 15.05.2010
Schlagworte:	Amino Acid Substitution - genetics Ethnic Groups - genetics Evolution, Molecular Haplotypes - genetics Humans Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Mutation - genetics Parkinson Disease - genetics Protein-Serine-Threonine Kinases - genetics
ISSN:	1460-2083, 1460-2083
Online-Zugang:	Weitere Angaben
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