Germline Genetic IKZF1 Variation and Predisposition to Childhood Acute Lymphoblastic Leukemia

Somatic genetic alterations of IKZF1, which encodes the lymphoid transcription factor IKAROS, are common in high-risk B-progenitor acute lymphoblastic leukemia (ALL) and are associated with poor prognosis. Such alterations result in the acquisition of stem cell-like features, overexpression of adhes...

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Bibliographic Details
Published in:	Cancer cell Vol. 33; no. 5; p. 937
Main Authors:	Churchman, Michelle L, Qian, Maoxiang, Te Kronnie, Geertruy, Zhang, Ranran, Yang, Wenjian, Zhang, Hui, Lana, Tobia, Tedrick, Paige, Baskin, Rebekah, Verbist, Katherine, Peters, Jennifer L, Devidas, Meenakshi, Larsen, Eric, Moore, Ian M, Gu, Zhaohui, Qu, Chunxu, Yoshihara, Hiroki, Porter, Shaina N, Pruett-Miller, Shondra M, Wu, Gang, Raetz, Elizabeth, Martin, Paul L, Bowman, W Paul, Winick, Naomi, Mardis, Elaine, Fulton, Robert, Stanulla, Martin, Evans, William E, Relling, Mary V, Pui, Ching-Hon, Hunger, Stephen P, Loh, Mignon L, Handgretinger, Rupert, Nichols, Kim E, Yang, Jun J, Mullighan, Charles G
Format:	Journal Article
Language:	English
Published:	United States 14.05.2018
Subjects:	Animals Child Female Frameshift Mutation Genetic Predisposition to Disease Germ-Line Mutation Humans Ikaros Transcription Factor - genetics Ikaros Transcription Factor - metabolism Male Mice Neoplasm Transplantation Pedigree Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism Sequence Analysis, DNA drug response ALL germline genetic variation acute lymphoblastic leukemia IKAROS predisposition immunodeficiency IKZF1 familial leukemia
ISSN:	1878-3686, 1878-3686
Online Access:	Get more information
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