Acute effects of oral mesna administration on the full amino acid profile and 3-methylhistidine: secondary results from the CYLOB dose-finding study

Plasma total cysteine (tCys) is strongly associated with fat mass in humans. Mesna lowers plasma tCys in a dose-dependent manner, but it is not known whether it interferes with metabolism of other amino acids or protein. In this Phase-1 study, we show that a single dose of mesna administered at 400,...

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Bibliographic Details
Published in:	Amino acids Vol. 56; no. 1; p. 39
Main Authors:	Olsen, Thomas, Elshorbagy, Amany, Stolt, Emma, Åsberg, Anders, Zaré, Hasse K., Bastani, Nasser E., Refsum, Helga, Retterstøl, Kjetil, Vinknes, Kathrine J.
Format:	Journal Article
Language:	English
Published:	Vienna Springer Vienna 06.06.2024 Springer Nature B.V Springer
Subjects:	3-methylhistidine Acute effects Administration, Oral Adult amino acid composition Amino acid profile Amino acids Amino Acids - blood Analytical Chemistry Biochemical Engineering Biochemistry Biomedical and Life Sciences Body composition Body fat Brief Report cysteine Cysteine - chemistry dose response Dose-Response Relationship, Drug Drug dosages Female Humans Life Sciences Male Medicine Mesna Metabolism Methylhistidines Middle Aged Musculoskeletal system Neurobiology Obesity Overweight Plasma Protein synthesis Protein turnover Proteins Proteomics Total cysteine Urine Valine Weight control Obesity Mesna Total cysteine Amino acid profile 3-methylhistidine Overweight
ISSN:	1438-2199, 0939-4451, 1438-2199
Online Access:	Get full text
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