Identification of anticancer drugs to radiosensitise BRAF -wild-type and mutant colorectal cancer

Patients with -mutant colorectal cancer (CRC) have a poor prognosis. Molecular status is not currently used to select which drug to use in combination with radiotherapy. Our aim was to identify drugs that radiosensitise CRC cells with known status. We screened 298 oncological drugs with and without...

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Vydáno v:	Cancer biology & medicine Ročník 16; číslo 2; s. 234 - 246
Hlavní autoři:	Rebecca, Carter, Azadeh, Cheraghchi-Bashi, Adam, Westhorpe, Sheng, Yu, Yasmin, Shanneik, Elena, Seraia, Djamila, Ouaret, Yasuhiro, Inoue, Catherine, Koch, Jenny, Wilding, Daniel, Ebner, Anderson, J. Ryan, Francesca, M. Buffa, Ricky, A. Sharma
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	China NIHR University College London Hospitals Biomedical Research Centre, UCL Cancer Institute, University College London, London WC1E 6DD, UK 01.05.2019 NIHR Oxford Biomedical Research Centre, Department of Oncology, University of Oxford, Oxford OX12JD, UK%NIHR Oxford Biomedical Research Centre, Department of Oncology, University of Oxford, Oxford OX12JD, UK%Computational Biology and Integrative Genomics, University of Oxford, Oxford OX12JD, UK%NDM Research Building, Nuffield Department of Medicine, University of Oxford, Oxford OX12JD, UK%Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX12JD, UK%Mie University, Graduate School of Medicine, Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Edobashi 2-174, Tsu, Japan%Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA%Target Discovery Institute, National Phenotypic Screening Centre, Nuffield Department of Medicine, University of Oxford, Oxford OX12JD, UK%CRUK & MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford OX12JD, UK Chinese Anti-Cancer Association China Anti-Cancer Association
Témata:	colorectal cancer Original PARP inhibitor Radiosensitizer radiotherapy radiotherapy Radiosensitizer colorectal cancer PARP inhibitor
ISSN:	2095-3941, 2095-3941
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