Nanoparticle-mediated codelivery of myelin antigen and a tolerogenic small molecule suppresses experimental autoimmune encephalomyelitis

The immune response is normally controlled by regulatory T cells (Tregs). However, Treg deficits are found in autoimmune diseases, and therefore the induction of functional Tregs is considered a potential therapeutic approach for autoimmune disorders. The activation of the ligand-activated transcrip...

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Vydané v:	Proceedings of the National Academy of Sciences - PNAS Ročník 109; číslo 28; s. 11270
Hlavní autori:	Yeste, Ada, Nadeau, Meghan, Burns, Evan J, Weiner, Howard L, Quintana, Francisco J
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 10.07.2012
Predmet:	Animals Autoimmune Diseases - immunology Cytokines - metabolism Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - therapy Epitopes - chemistry Epitopes, T-Lymphocyte - chemistry Genes, Reporter Humans Immune System - physiology Ligands Mice Mice, Inbred C57BL Microscopy, Electron, Transmission - methods Microsomes, Liver - metabolism Multiple Sclerosis - metabolism Myelin Sheath - immunology Nanoparticles - chemistry Nanotechnology - methods T-Lymphocytes, Regulatory - cytology
ISSN:	1091-6490, 1091-6490
On-line prístup:	Zistit podrobnosti o prístupe
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