Nanoparticle-mediated codelivery of myelin antigen and a tolerogenic small molecule suppresses experimental autoimmune encephalomyelitis

The immune response is normally controlled by regulatory T cells (Tregs). However, Treg deficits are found in autoimmune diseases, and therefore the induction of functional Tregs is considered a potential therapeutic approach for autoimmune disorders. The activation of the ligand-activated transcrip...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS Jg. 109; H. 28; S. 11270
Hauptverfasser:	Yeste, Ada, Nadeau, Meghan, Burns, Evan J, Weiner, Howard L, Quintana, Francisco J
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 10.07.2012
Schlagworte:	Animals Autoimmune Diseases - immunology Cytokines - metabolism Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - therapy Epitopes - chemistry Epitopes, T-Lymphocyte - chemistry Genes, Reporter Humans Immune System - physiology Ligands Mice Mice, Inbred C57BL Microscopy, Electron, Transmission - methods Microsomes, Liver - metabolism Multiple Sclerosis - metabolism Myelin Sheath - immunology Nanoparticles - chemistry Nanotechnology - methods T-Lymphocytes, Regulatory - cytology
ISSN:	1091-6490, 1091-6490
Online-Zugang:	Weitere Angaben
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