Atypical angiopoietin-like protein that regulates ANGPTL3

Angiopoietin-like proteins (ANGPTLs) play major roles in the trafficking and metabolism of lipids. Inactivation of ANGPTL3, a gene located in an intron of DOCK7, results in very low levels of LDL-cholesterol (C), HDL-C and triglyceride (TAG). We identified another ANGPTL family member, ANGPTL8, whic...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 109; no. 48; p. 19751
Main Authors:	Quagliarini, Fabiana, Wang, Yan, Kozlitina, Julia, Grishin, Nick V, Hyde, Rhonda, Boerwinkle, Eric, Valenzuela, David M, Murphy, Andrew J, Cohen, Jonathan C, Hobbs, Helen H
Format:	Journal Article
Language:	English
Published:	United States 27.11.2012
Subjects:	Amino Acid Sequence Angiopoietin-like Proteins Angiopoietins - chemistry Angiopoietins - metabolism Angiopoietins - physiology Animals Cholesterol, HDL - blood Cholesterol, LDL - blood Guanine Nucleotide Exchange Factors - genetics Hypertriglyceridemia - physiopathology Introns Liver - metabolism Mice Molecular Sequence Data Sequence Homology, Amino Acid Triglycerides - blood
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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