Pyruvate Kinase M2 and Cancer: The Role of PKM2 in Promoting Tumorigenesis

Pyruvate kinase plays a pivotal role in regulating cell metabolism. The final and rate-limiting step of glycolysis is the conversion of Phosphoenolpyruvate (PEP) to Pyruvate, which is catalyzed by Pyruvate Kinase. There are four isomeric, tissue-specific forms of Pyruvate Kinase found in mammals: PK...

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Bibliographic Details

Published in:	Frontiers in oncology Vol. 10; p. 159
Main Authors:	Zahra, Kulsoom, Dey, Tulika, Ashish, Mishra, Surendra Pratap, Pandey, Uma
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 02.03.2020
Subjects:	anaerobic glycolysis angiogenesis cancer metabolism chemotherapy Oncology pyruvate kinase M2 cancer metabolism anaerobic glycolysis chemotherapy angiogenesis pyruvate kinase M2
ISSN:	2234-943X, 2234-943X
Online Access:	Get full text
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