Quantifying the flash effect and its dependence on average dose rate in vivo for 6 MeV electron and 6 MV photon beams
•Increasing the average dose rate delays the onset, and reduces the severity, of radiation induced skin toxicity.•Similar FLASH effect following 6 MV photon and 6 MeV electron beam irradiation.•30 Gy/s shows a dose modifying factor (DMF) of ≈1.2–1.25, for both photon and electron beams.•DMF was incr...
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| Published in: | Clinical and translational radiation oncology Vol. 56; p. 101052 |
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| Abstract | •Increasing the average dose rate delays the onset, and reduces the severity, of radiation induced skin toxicity.•Similar FLASH effect following 6 MV photon and 6 MeV electron beam irradiation.•30 Gy/s shows a dose modifying factor (DMF) of ≈1.2–1.25, for both photon and electron beams.•DMF was increased to ≈1.5 for our highest used electron dose rates (≥1,800 Gy/s).•Radiotherapy is mainly delivered with MV photon beams, highlighting its importance as a future clinical modality for FLASH.
This study shows that an increase in average dose rate delays the onset, and reduces the severity, of radiation induced skin toxicity in mice following hemi-thorax irradiation. The FLASH sparing effect’s magnitude and dependence on dose rate appear similar following irradiations using 6 MV photon and 6 MeV electron beams. |
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| AbstractList | This study shows that an increase in average dose rate delays the onset, and reduces the severity, of radiation induced skin toxicity in mice following hemi-thorax irradiation. The FLASH sparing effect's magnitude and dependence on dose rate appear similar following irradiations using 6 MV photon and 6 MeV electron beams. Highlights•Increasing the average dose rate delays the onset, and reduces the severity, of radiation induced skin toxicity. •Similar FLASH effect following 6 MV photon and 6 MeV electron beam irradiation. •30 Gy/s shows a dose modifying factor (DMF) of ≈1.2–1.25, for both photon and electron beams. •DMF was increased to ≈1.5 for our highest used electron dose rates (≥1,800 Gy/s). •Radiotherapy is mainly delivered with MV photon beams, highlighting its importance as a future clinical modality for FLASH. •Increasing the average dose rate delays the onset, and reduces the severity, of radiation induced skin toxicity.•Similar FLASH effect following 6 MV photon and 6 MeV electron beam irradiation.•30 Gy/s shows a dose modifying factor (DMF) of ≈1.2–1.25, for both photon and electron beams.•DMF was increased to ≈1.5 for our highest used electron dose rates (≥1,800 Gy/s).•Radiotherapy is mainly delivered with MV photon beams, highlighting its importance as a future clinical modality for FLASH. This study shows that an increase in average dose rate delays the onset, and reduces the severity, of radiation induced skin toxicity in mice following hemi-thorax irradiation. The FLASH sparing effect’s magnitude and dependence on dose rate appear similar following irradiations using 6 MV photon and 6 MeV electron beams. This study shows that an increase in average dose rate delays the onset, and reduces the severity, of radiation induced skin toxicity in mice following hemi-thorax irradiation. The FLASH sparing effect's magnitude and dependence on dose rate appear similar following irradiations using 6 MV photon and 6 MeV electron beams.This study shows that an increase in average dose rate delays the onset, and reduces the severity, of radiation induced skin toxicity in mice following hemi-thorax irradiation. The FLASH sparing effect's magnitude and dependence on dose rate appear similar following irradiations using 6 MV photon and 6 MeV electron beams. |
| ArticleNumber | 101052 |
| Author | Lövgren, Nathalie Paillas, Salomé Tullis, Iain D.C. Petersson, Kristoffer Taylor, Edward R.J.F. |
| Author_xml | – sequence: 1 givenname: Salomé orcidid: 0000-0003-0240-7528 surname: Paillas fullname: Paillas, Salomé – sequence: 2 givenname: Edward R.J.F. orcidid: 0000-0001-9617-8206 surname: Taylor fullname: Taylor, Edward R.J.F. – sequence: 3 givenname: Nathalie orcidid: 0009-0003-6668-1195 surname: Lövgren fullname: Lövgren, Nathalie – sequence: 4 givenname: Iain D.C. orcidid: 0000-0001-5148-0161 surname: Tullis fullname: Tullis, Iain D.C. – sequence: 5 givenname: Kristoffer orcidid: 0000-0003-0300-5790 surname: Petersson fullname: Petersson, Kristoffer email: kristoffer.petersson@oncology.ox.ac.uk |
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| Cites_doi | 10.1016/j.radonc.2018.08.016 10.1038/s41598-023-50412-w 10.1016/j.ijrobp.2024.04.071 10.1002/mp.12111 10.1016/j.radonc.2021.12.022 10.1038/s41598-018-30543-1 10.1016/j.radonc.2023.109967 10.1667/RR1880.1 10.3389/fonc.2019.01563 10.1002/mp.15222 10.1088/1361-6560/abf2fa 10.1016/j.radonc.2017.05.003 10.1093/jrr/rrae079 10.1088/1361-6560/abd672 10.1016/j.radonc.2025.110796 10.1016/j.ijrobp.2025.04.021 10.1016/j.ijrobp.2021.08.004 10.1002/mp.17891 10.1016/j.ijrobp.2024.02.050 |
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