Identification of Genetic Determinants and Enzymes Involved with the Amidation of Glutamic Acid Residues in the Peptidoglycan of Staphylococcus aureus

The glutamic acid residues of the peptidoglycan of Staphylococcus aureus and many other bacteria become amidated by an as yet unknown mechanism. In this communication we describe the identification, in the genome of S. aureus strain COL, of two co-transcribed genes, murT and gatD, which are responsi...

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Bibliographic Details
Published in:	PLoS pathogens Vol. 8; no. 1; p. e1002508
Main Authors:	Figueiredo, Teresa A., Sobral, Rita G., Ludovice, Ana Madalena, de Almeida, João Manuel Feio, Bui, Nhat K., Vollmer, Waldemar, de Lencastre, Hermínia, Tomasz, Alexander
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.01.2012 Public Library of Science (PLoS)
Subjects:	Amidohydrolases - genetics Amidohydrolases - metabolism Amino Acid Sequence Antibiotics Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacteriology Biology Biosynthesis Blotting, Northern Chromatography, High Pressure Liquid Drug resistance Enzymes Experiments Genes, Bacterial - genetics Genomes Glutamic Acid - metabolism Gram-positive bacteria Growth rate Lipids Mass Spectrometry Microbiology Molecular Sequence Data Peptides Peptidoglycan - metabolism Plasmids Reverse Transcriptase Polymerase Chain Reaction Staphylococcus aureus - genetics Staphylococcus aureus - metabolism Amidohydrolases Glutamic Acid Amino Acid Sequence Genes, Bacterial Peptidoglycan Blotting, Northern Mass Spectrometry Molecular Sequence Data Chromatography, High Pressure Liquid Reverse Transcriptase Polymerase Chain Reaction Staphylococcus aureus Bacterial Proteins
ISSN:	1553-7374, 1553-7366, 1553-7374
Online Access:	Get full text
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