Direct reprogramming of fibroblasts into endothelial cells capable of angiogenesis and reendothelialization in tissue-engineered vessels

The generation of induced pluripotent stem (iPS) cells is an important tool for regenerative medicine. However, the main restriction is the risk of tumor development. In this study we found that during the early stages of somatic cell reprogramming toward a pluripotent state, specific gene expressio...

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Vydané v:	Proceedings of the National Academy of Sciences - PNAS Ročník 109; číslo 34; s. 13793
Hlavní autori:	Margariti, Andriana, Winkler, Bernhard, Karamariti, Eirini, Zampetaki, Anna, Tsai, Tsung-neng, Baban, Dilair, Ragoussis, Jiannis, Huang, Yi, Han, Jing-Dong J, Zeng, Lingfang, Hu, Yanhua, Xu, Qingbo
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 21.08.2012
Predmet:	Animals Antigens, CD - genetics Aorta - pathology Cadherins - genetics Cell Differentiation Cells, Cultured Cellular Reprogramming Endothelial Cells - cytology Fibroblasts - cytology Fibroblasts - metabolism Humans Induced Pluripotent Stem Cells - cytology Kruppel-Like Factor 4 Mice Mice, SCID Models, Genetic Neovascularization, Pathologic Promoter Regions, Genetic Stem Cells - cytology Stress, Mechanical Tissue Engineering - methods
ISSN:	1091-6490, 1091-6490
On-line prístup:	Zistit podrobnosti o prístupe
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