Targeting Vascular NADPH Oxidase 1 Blocks Tumor Angiogenesis through a PPARα Mediated Mechanism

Reactive oxygen species, ROS, are regulators of endothelial cell migration, proliferation and survival, events critically involved in angiogenesis. Different isoforms of ROS-generating NOX enzymes are expressed in the vasculature and provide distinct signaling cues through differential localization...

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Bibliographic Details
Published in:	PloS one Vol. 6; no. 2; p. e14665
Main Authors:	Garrido-Urbani, Sarah, Jemelin, Stephane, Deffert, Christine, Carnesecchi, Stéphanie, Basset, Olivier, Szyndralewiez, Cédric, Heitz, Freddy, Page, Patrick, Montet, Xavier, Michalik, Liliane, Arbiser, Jack, Rüegg, Curzio, Krause, Karl Heinz, Imhof, Beat
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 07.02.2011 Public Library of Science (PLoS)
Subjects:	Angiogenesis Angiogenesis Inhibitors - pharmacology Angiogenesis Inhibitors - therapeutic use Animals Cancer Cardiovascular Disorders/Vascular Biology Cell adhesion & migration Cell Biology Cell migration Cell survival Cells, Cultured Cues CYBB protein Endothelial cells Endothelial Cells - drug effects Endothelial Cells - metabolism Female Fibroblasts Gene Knockdown Techniques Gene Targeting Humans Immunoglobulins Immunology Isoforms Kinases Leukocyte migration Localization Medical imaging Metastasis Mice Mice, Inbred C57BL Mice, Knockout Models, Biological Molecular Targeted Therapy NAD(P)H oxidase NADH, NADPH Oxidoreductases - antagonists & inhibitors NADH, NADPH Oxidoreductases - genetics NADH, NADPH Oxidoreductases - physiology NADPH Oxidase 1 Neoplasms - blood supply Neoplasms - drug therapy Neoplasms - genetics Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - genetics NF-κB protein NOX4 protein Oncology Oxygen Pathology PPAR alpha - genetics PPAR alpha - physiology Proteins Pyrazoles - pharmacology Pyrazoles - therapeutic use Pyridones - pharmacology Pyridones - therapeutic use Reactive oxygen species Regulators RNA, Small Interfering - pharmacology Rodents Signal Transduction - drug effects Signal Transduction - genetics Signaling Tomography Tumors Switzerland
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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