Infrared microspectroscopy analysis of Ibuprofen release from drug eluting beads in uterine tissue

Ibuprofen loaded embolization beads (IBU-BB) have been developed to reduce inflammation and pain following uterine artery embolization for the treatment of uterine fibroids. The present work has investigated the elution properties of IBU-BB in situ after embolization with Fourier Transform Infrared...

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Vydáno v:Journal of controlled release Ročník 135; číslo 3; s. 198 - 202
Hlavní autoři: Namur, J., Wassef, M., Pelage, J.P., Lewis, A., Manfait, M., Laurent, A.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Kidlington Elsevier B.V 05.05.2009
Elsevier
Témata:
Animals
Anti-Inflammatory Agents, Non-Steroidal - analysis
Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics
Biological and medical sciences
Calibration
Delayed-Action Preparations
Dose-Response Relationship, Drug
Drug eluting beads
Embolization
Embolization, Therapeutic
Female
General pharmacology
Ibuprofen
Ibuprofen - analysis
Ibuprofen - pharmacokinetics
In vivo drug release
Infrared microspectroscopy
Medical sciences
Microspheres
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Sensitivity and Specificity
Sheep, Domestic
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Spectroscopy, Fourier Transform Infrared
Time Factors
Uterus - blood supply
Embolization
In vivo drug release
Drug eluting beads
Infrared microspectroscopy
Ibuprofen
Drug
Prostaglandin-endoperoxide synthase
Pharmaceutical technology
Enzyme
Enzyme inhibitor
Non steroidal antiinflammatory agent
In vivo
Tissue
Arylpropionic acid derivatives
Oxidoreductases
Release
ISSN:0168-3659, 1873-4995, 1873-4995
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Shrnutí:Ibuprofen loaded embolization beads (IBU-BB) have been developed to reduce inflammation and pain following uterine artery embolization for the treatment of uterine fibroids. The present work has investigated the elution properties of IBU-BB in situ after embolization with Fourier Transform Infrared Microspectroscopy (FTIRMS). Twelve sheep underwent uterine artery embolization with IBU-BB (485 mM) or control unloaded beads. IBU concentration was determined inside the beads and in the tissue surrounding the beads using FTIRMS of uterine tissue sections sampled 24 h or 1 week after embolization. After 24 h, IBU concentration inside the bead was only 18.6 mM out of the 485 mM initially loaded ( p < 0.0001, univariate sign test). The concentration in the tissue around the beads was 8 mM, which is well above the in vitro therapeutic levels (6 µM). After one week the concentration of IBU had decreased to 4.9 mM in the beads ( p = 0.0502, Mann Whitney) and no IBU was detected in the surrounding tissue. This work has demonstrated that IBU-BB can provide a sustained release of the anti-inflammatory drug over at least one week. The in vivo elution properties of IBU-BB may be suitable to alleviate pain and inflammation after embolization. [Display omitted]
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0168-3659
1873-4995
1873-4995
DOI:10.1016/j.jconrel.2008.12.017