Hyperforin Potentiates Antidepressant-Like Activity of Lanicemine in Mice

N-methyl-D-aspartate receptor (NMDAR) modulators induce rapid and sustained antidepressant like-activity in rodents through a molecular mechanism of action that involves the activation of Ca dependent signaling pathways. Moreover, ketamine, a global NMDAR antagonist is a potent, novel, and atypical...

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Veröffentlicht in:	Frontiers in molecular neuroscience Jg. 11; S. 456
Hauptverfasser:	Pochwat, Bartłomiej, Szewczyk, Bernadeta, Kotarska, Katarzyna, Rafało-Ulińska, Anna, Siwiec, Marcin, Sowa, Joanna E., Tokarski, Krzysztof, Siwek, Agata, Bouron, Alexandre, Friedland, Kristina, Nowak, Gabriel
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Switzerland Frontiers Research Foundation 12.12.2018 Frontiers Media Frontiers Media S.A
Schlagworte:	AKT protein Antidepressants Brain-derived neurotrophic factor Calcium (intracellular) Calcium imaging Calcium influx Calcium signalling Clinical trials Cognitive ability Cortex (frontal) Corticosterone depression Dizocilpine Drug dosages Enzyme inhibitors Glutamic acid receptors hyperforin Ketamine lanicemine Life Sciences Mental depression N-Methyl-D-aspartic acid receptors Neurobiology Neuroimaging Neuromodulation Neurons and Cognition Neuroscience Neurosciences NMDA - receptor Pattern recognition Pharmaceutical sciences Pharmacy Psychiatry Psychotropic drugs Studies Synapsin I Transient receptor potential proteins TRPC 6 Western blotting Poland TRPC 6 hyperforin depression ketamine lanicemine NMDA - receptor
ISSN:	1662-5099, 1662-5099
Online-Zugang:	Volltext
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