Characterization of an adaptive immune response in microsatellite-instable colorectal cancer

Sporadic or hereditary colorectal cancer (CRC) with microsatellite instability (MSI) is frequently characterized by inflammatory lymphocytic infiltration and tends to be associated with a better outcome than microsatellite stable (MSS) CRC, probably reflecting a more effective immune response. We in...

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Published in:Oncoimmunology Vol. 3; no. 6; p. e29256
Main Authors: Boissière-Michot, Florence, Lazennec, Gwendal, Frugier, Hélène, Jarlier, Marta, Roca, Lise, Duffour, Jacqueline, Du Paty, Emilie, Laune, Daniel, Blanchard, France, Le Pessot, Florence, Sabourin, Jean-Christophe, Bibeau, Frédéric
Format: Journal Article
Language:English
Published: United States Taylor & Francis 01.06.2014
Landes Bioscience
Subjects:
Adaptive immunology
Cancer
chemokine
colorectal cancer
cytokine
Human health and pathology
Hépatology and Gastroenterology
Immunology
inflammation
Life Sciences
microsatellite instability
Original Research
cytokine
microsatellite instability
chemokine
colorectal cancer
inflammation
ISSN:2162-402X, 2162-4011, 2162-402X
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Abstract Sporadic or hereditary colorectal cancer (CRC) with microsatellite instability (MSI) is frequently characterized by inflammatory lymphocytic infiltration and tends to be associated with a better outcome than microsatellite stable (MSS) CRC, probably reflecting a more effective immune response. We investigated inflammatory mechanisms in 48 MSI CRCs and 62 MSS CRCs by analyzing: (1) the expression of 48 cytokines using Bio-Plex multiplex cytokine assays, and (2) the in situ immune response by immunohistochemical analysis with antibodies against CD3 (T lymphocytes), CD8 (cytotoxic T lymphocytes), CD45RO (memory T lymphocytes), T-bet (Th1 CD4 cells), and FoxP3 (regulatory T cells). MSI CRC exhibited significantly higher expression of CCL5 (RANTES), CXCL8 (IL-8), CXCL9 (MIG), IL-1β, CXCL10 (IP-10), IL-16, CXCL1 (GROα), and IL-1ra, and lower expression of MIF, compared with MSS CRC. Immunohistochemistry combined with image analysis indicated that the density of CD3 + , CD8 + , CD45RO + , and T-bet + T lymphocytes was higher in MSI CRC than in MSS CRC, whereas the number of regulatory T cells (FoxP3 + ) was not statistically different between the groups. These results indicate that MSI CRC is associated with a specific cytokine expression profile that includes CCL5, CXCL10, and CXCL9, which are involved in the T helper type 1 (Th1) response and in the recruitment of memory CD45RO + T cells. Our findings highlight the major role of adaptive immunity in MSI CRC and provide a possible explanation for the more favorable prognosis of this CRC subtype.
AbstractList Sporadic or hereditary colorectal cancer (CRC) with microsatellite instability (MSI) is frequently characterized by inflammatory lymphocytic infiltration and tends to be associated with a better outcome than microsatellite stable (MSS) CRC, probably reflecting a more effective immune response. We investigated inflammatory mechanisms in 48 MSI CRCs and 62 MSS CRCs by analyzing: (1) the expression of 48 cytokines using Bio-Plex multiplex cytokine assays, and (2) the in situ immune response by immunohistochemical analysis with antibodies against CD3 (T lymphocytes), CD8 (cytotoxic T lymphocytes), CD45RO (memory T lymphocytes), T-bet (Th1 CD4 cells), and FoxP3 (regulatory T cells). MSI CRC exhibited significantly higher expression of CCL5 (RANTES), CXCL8 (IL-8), CXCL9 (MIG), IL-1β, CXCL10 (IP-10), IL-16, CXCL1 (GROα), and IL-1ra, and lower expression of MIF, compared with MSS CRC. Immunohistochemistry combined with image analysis indicated that the density of CD3 , CD8 , CD45RO , and T-bet T lymphocytes was higher in MSI CRC than in MSS CRC, whereas the number of regulatory T cells (FoxP3 ) was not statistically different between the groups. These results indicate that MSI CRC is associated with a specific cytokine expression profile that includes CCL5, CXCL10, and CXCL9, which are involved in the T helper type 1 (Th1) response and in the recruitment of memory CD45RO T cells. Our findings highlight the major role of adaptive immunity in MSI CRC and provide a possible explanation for the more favorable prognosis of this CRC subtype.
Sporadic or hereditary colorectal cancer (CRC) with microsatellite instability (MSI) is frequently characterized by inflammatory lymphocytic infiltration and tends to be associated with a better outcome than microsatellite stable (MSS) CRC, probably reflecting a more effective immune response. We investigated inflammatory mechanisms in 48 MSI CRCs and 62 MSS CRCs by analyzing: (1) the expression of 48 cytokines using Bio-Plex multiplex cytokine assays, and (2) the in situ immune response by immunohistochemical analysis with antibodies against CD3 (T lymphocytes), CD8 (cytotoxic T lymphocytes), CD45RO (memory T lymphocytes), T-bet (Th1 CD4 cells), and FoxP3 (regulatory T cells). MSI CRC exhibited significantly higher expression of CCL5 (RANTES), CXCL8 (IL-8), CXCL9 (MIG), IL-1β, CXCL10 (IP-10), IL-16, CXCL1 (GROα), and IL-1ra, and lower expression of MIF, compared with MSS CRC. Immunohistochemistry combined with image analysis indicated that the density of CD3 + , CD8 + , CD45RO + , and T-bet + T lymphocytes was higher in MSI CRC than in MSS CRC, whereas the number of regulatory T cells (FoxP3 + ) was not statistically different between the groups. These results indicate that MSI CRC is associated with a specific cytokine expression profile that includes CCL5, CXCL10, and CXCL9, which are involved in the T helper type 1 (Th1) response and in the recruitment of memory CD45RO + T cells. Our findings highlight the major role of adaptive immunity in MSI CRC and provide a possible explanation for the more favorable prognosis of this CRC subtype.
Sporadic or hereditary colorectal cancer (CRC) with microsatellite instability (MSI) is frequently characterized by inflammatory lymphocytic infiltration and tends to be associated with a better outcome than microsatellite stable (MSS) CRC, probably reflecting a more effective immune response. We investigated inflammatory mechanisms in 48 MSI CRCs and 62 MSS CRCs by analyzing: (1) the expression of 48 cytokines using Bio-Plex multiplex cytokine assays, and (2) the in situ immune response by immunohistochemical analysis with antibodies against CD3 (T lymphocytes), CD8 (cytotoxic T lymphocytes), CD45RO (memory T lymphocytes), T-bet (Th1 CD4 cells), and FoxP3 (regulatory T cells). MSI CRC exhibited significantly higher expression of CCL5 (RANTES), CXCL8 (IL-8), CXCL9 (MIG), IL-1β, CXCL10 (IP-10), IL-16, CXCL1 (GROα), and IL-1ra, and lower expression of MIF, compared with MSS CRC. Immunohistochemistry combined with image analysis indicated that the density of CD3+, CD8+, CD45RO+, and T-bet+ T lymphocytes was higher in MSI CRC than in MSS CRC, whereas the number of regulatory T cells (FoxP3+) was not statistically different between the groups. These results indicate that MSI CRC is associated with a specific cytokine expression profile that includes CCL5, CXCL10, and CXCL9, which are involved in the T helper type 1 (Th1) response and in the recruitment of memory CD45RO+ T cells. Our findings highlight the major role of adaptive immunity in MSI CRC and provide a possible explanation for the more favorable prognosis of this CRC subtype.
Sporadic or hereditary colorectal cancer (CRC) with microsatellite instability (MSI) is frequently characterized by inflammatory lymphocytic infiltration and tends to be associated with a better outcome than microsatellite stable (MSS) CRC, probably reflecting a more effective immune response. We investigated inflammatory mechanisms in 48 MSI CRCs and 62 MSS CRCs by analyzing: (1) the expression of 48 cytokines using Bio-Plex multiplex cytokine assays, and (2) the in situ immune response by immunohistochemical analysis with antibodies against CD3 (T lymphocytes), CD8 (cytotoxic T lymphocytes), CD45RO (memory T lymphocytes), T-bet (Th1 CD4 cells), and FoxP3 (regulatory T cells). MSI CRC exhibited significantly higher expression of CCL5 (RANTES), CXCL8 (IL-8), CXCL9 (MIG), IL-1β, CXCL10 (IP-10), IL-16, CXCL1 (GROα), and IL-1ra, and lower expression of MIF, compared with MSS CRC. Immunohistochemistry combined with image analysis indicated that the density of CD3+, CD8+, CD45RO+, and T-bet+ T lymphocytes was higher in MSI CRC than in MSS CRC, whereas the number of regulatory T cells (FoxP3+) was not statistically different between the groups. These results indicate that MSI CRC is associated with a specific cytokine expression profile that includes CCL5, CXCL10, and CXCL9, which are involved in the T helper type 1 (Th1) response and in the recruitment of memory CD45RO+ T cells. Our findings highlight the major role of adaptive immunity in MSI CRC and provide a possible explanation for the more favorable prognosis of this CRC subtype.Sporadic or hereditary colorectal cancer (CRC) with microsatellite instability (MSI) is frequently characterized by inflammatory lymphocytic infiltration and tends to be associated with a better outcome than microsatellite stable (MSS) CRC, probably reflecting a more effective immune response. We investigated inflammatory mechanisms in 48 MSI CRCs and 62 MSS CRCs by analyzing: (1) the expression of 48 cytokines using Bio-Plex multiplex cytokine assays, and (2) the in situ immune response by immunohistochemical analysis with antibodies against CD3 (T lymphocytes), CD8 (cytotoxic T lymphocytes), CD45RO (memory T lymphocytes), T-bet (Th1 CD4 cells), and FoxP3 (regulatory T cells). MSI CRC exhibited significantly higher expression of CCL5 (RANTES), CXCL8 (IL-8), CXCL9 (MIG), IL-1β, CXCL10 (IP-10), IL-16, CXCL1 (GROα), and IL-1ra, and lower expression of MIF, compared with MSS CRC. Immunohistochemistry combined with image analysis indicated that the density of CD3+, CD8+, CD45RO+, and T-bet+ T lymphocytes was higher in MSI CRC than in MSS CRC, whereas the number of regulatory T cells (FoxP3+) was not statistically different between the groups. These results indicate that MSI CRC is associated with a specific cytokine expression profile that includes CCL5, CXCL10, and CXCL9, which are involved in the T helper type 1 (Th1) response and in the recruitment of memory CD45RO+ T cells. Our findings highlight the major role of adaptive immunity in MSI CRC and provide a possible explanation for the more favorable prognosis of this CRC subtype.
Author Roca, Lise
Duffour, Jacqueline
Laune, Daniel
Boissière-Michot, Florence
Blanchard, France
Le Pessot, Florence
Jarlier, Marta
Sabourin, Jean-Christophe
Lazennec, Gwendal
Du Paty, Emilie
Frugier, Hélène
Bibeau, Frédéric
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  surname: Boissière-Michot
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  surname: Lazennec
  fullname: Lazennec, Gwendal
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  surname: Frugier
  fullname: Frugier, Hélène
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  givenname: Marta
  surname: Jarlier
  fullname: Jarlier, Marta
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  surname: Roca
  fullname: Roca, Lise
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  surname: Duffour
  fullname: Duffour, Jacqueline
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  surname: Du Paty
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  surname: Laune
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  fullname: Sabourin, Jean-Christophe
– sequence: 12
  givenname: Frédéric
  surname: Bibeau
  fullname: Bibeau, Frédéric
  email: Frederic.Bibeau@icm.unicancer.fr
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Cites_doi 10.2353/jmoldx.2008.070082
10.1093/hmg/10.5.513
10.1002/cncr.25293
10.1007/s00262-009-0702-y
10.1016/j.cyto.2011.10.019
10.1111/j.1365-2559.2006.02549.x
10.1038/nature07205
10.1038/nri748
10.1371/journal.pone.0028842
10.1002/bjs.4472
10.1186/1471-2407-8-178
10.1158/1078-0432.CCR-11-3216
10.1016/S0002-9440(10)61695-1
10.1038/sj.bjc.6604756
10.1111/j.1365-2559.1986.tb02497.x
10.1200/JCO.2008.19.6147
10.1073/pnas.0913683107
10.1189/jlb.1107773
10.1053/j.gastro.2008.01.015
10.1136/gut.2007.123794
10.1186/bcr1648
10.1084/jem.20052124
10.1677/ERC-09-0109
10.1158/1078-0432.CCR-10-2173
10.1038/nrc3245
10.1016/S1470-2045(09)70186-X
10.1038/nrc1388
10.1073/pnas.231326898
10.1016/j.molmed.2010.01.003
10.1002/path.2803
10.1002/path.2774
10.1371/journal.pone.0026264
10.1053/j.gastro.2009.10.057
10.1160/TH07-01-0040
10.1007/s00262-009-0781-9
10.1038/nri3024
10.1002/ijc.24989
10.1016/S0002-9440(10)65436-3
10.1126/science.1129139
10.1016/S0959-8049(96)00221-3
10.1126/science.1059835
10.1158/1055-9965.EPI-04-0396
10.1189/jlb.71.4.669
10.1186/1476-4598-3-21
10.1016/j.ejca.2006.01.006
10.1038/nature01322
10.1002/ijc.25562
10.1158/0008-5472.CAN-11-2493
10.1097/00024382-199509000-00001
10.1093/carcin/bgp127
10.1016/j.humpath.2004.01.022
10.1002/ijc.21135
10.1038/sj.bjc.6606055
10.1016/j.canlet.2008.03.018
10.1172/JCI31202
10.1200/JCO.2009.27.1825
10.1136/gut.2008.158824
10.1056/NEJMoa051424
10.1038/modpathol.2009.80
10.1200/JCO.2008.18.7229
10.1038/sj.bjc.6690164
10.1158/0008-5472.CAN-10-2907
10.1002/jcp.24260
10.1007/s10555-007-9073-z
10.1007/s11033-009-9873-z
10.1053/j.gastro.2009.06.053
10.1016/j.cell.2011.02.013
10.1002/ijc.23401
10.1007/s12253-012-9556-2
10.1097/CJI.0b013e3181d32f01
10.1038/nri3049
10.1002/ijc.1298
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Issue 6
Keywords cytokine
microsatellite instability
chemokine
colorectal cancer
inflammation
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References R61
R60
R63
R62
R65
R20
R64
R23
R67
R22
R25
R69
R24
R68
R27
R26
R29
R28
R1
R2
R3
R4
R5
R6
R7
R8
R9
R70
R72
Padovan E (R66) 2002; 71
R71
R30
R32
R31
R34
R33
R36
R35
R38
R39
R41
R40
R43
R42
R45
R44
R47
R46
R49
R48
R50
Mehrad B (R21) 2007; 97
Frey DM (R37) 2010; 126
R52
R51
R10
R54
R53
R12
R56
R11
R55
R14
R58
R13
R57
R16
R15
R59
R18
R17
R19
References_xml – ident: R7
  doi: 10.2353/jmoldx.2008.070082
– ident: R8
  doi: 10.1093/hmg/10.5.513
– ident: R46
  doi: 10.1002/cncr.25293
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  doi: 10.1007/s00262-009-0702-y
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  doi: 10.1016/j.cyto.2011.10.019
– ident: R6
  doi: 10.1111/j.1365-2559.2006.02549.x
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  doi: 10.1038/nature07205
– ident: R57
  doi: 10.1038/nri748
– ident: R61
  doi: 10.1371/journal.pone.0028842
– ident: R10
  doi: 10.1002/bjs.4472
– ident: R48
  doi: 10.1186/1471-2407-8-178
– ident: R44
  doi: 10.1158/1078-0432.CCR-11-3216
– ident: R31
  doi: 10.1016/S0002-9440(10)61695-1
– ident: R33
  doi: 10.1038/sj.bjc.6604756
– ident: R70
  doi: 10.1111/j.1365-2559.1986.tb02497.x
– ident: R38
  doi: 10.1200/JCO.2008.19.6147
– ident: R43
  doi: 10.1073/pnas.0913683107
– ident: R29
  doi: 10.1189/jlb.1107773
– ident: R13
  doi: 10.1053/j.gastro.2008.01.015
– ident: R25
  doi: 10.1136/gut.2007.123794
– ident: R72
  doi: 10.1186/bcr1648
– ident: R49
  doi: 10.1084/jem.20052124
– ident: R17
  doi: 10.1677/ERC-09-0109
– ident: R28
  doi: 10.1158/1078-0432.CCR-10-2173
– ident: R2
  doi: 10.1038/nrc3245
– ident: R32
  doi: 10.1016/S1470-2045(09)70186-X
– ident: R56
  doi: 10.1038/nrc1388
– ident: R14
  doi: 10.1073/pnas.231326898
– ident: R15
  doi: 10.1016/j.molmed.2010.01.003
– ident: R24
  doi: 10.1002/path.2803
– ident: R30
  doi: 10.1002/path.2774
– ident: R67
  doi: 10.1371/journal.pone.0026264
– ident: R3
  doi: 10.1053/j.gastro.2009.10.057
– volume: 97
  start-page: 755
  year: 2007
  ident: R21
  publication-title: Thromb Haemost
  doi: 10.1160/TH07-01-0040
– ident: R39
  doi: 10.1007/s00262-009-0781-9
– ident: R54
  doi: 10.1038/nri3024
– volume: 126
  start-page: 2635
  year: 2010
  ident: R37
  publication-title: Int J Cancer
  doi: 10.1002/ijc.24989
– ident: R9
  doi: 10.1016/S0002-9440(10)65436-3
– ident: R5
  doi: 10.1126/science.1129139
– ident: R52
  doi: 10.1016/S0959-8049(96)00221-3
– ident: R36
  doi: 10.1126/science.1059835
– ident: R69
  doi: 10.1158/1055-9965.EPI-04-0396
– volume: 71
  start-page: 669
  year: 2002
  ident: R66
  publication-title: J Leukoc Biol
  doi: 10.1189/jlb.71.4.669
– ident: R64
  doi: 10.1186/1476-4598-3-21
– ident: R20
  doi: 10.1016/j.ejca.2006.01.006
– ident: R22
  doi: 10.1038/nature01322
– ident: R63
  doi: 10.1002/ijc.25562
– ident: R62
  doi: 10.1158/0008-5472.CAN-11-2493
– ident: R65
  doi: 10.1097/00024382-199509000-00001
– ident: R18
  doi: 10.1093/carcin/bgp127
– ident: R34
  doi: 10.1016/j.humpath.2004.01.022
– ident: R51
  doi: 10.1002/ijc.21135
– ident: R27
  doi: 10.1038/sj.bjc.6606055
– ident: R60
  doi: 10.1016/j.canlet.2008.03.018
– ident: R41
  doi: 10.1172/JCI31202
– ident: R11
  doi: 10.1200/JCO.2009.27.1825
– ident: R42
  doi: 10.1136/gut.2008.158824
– ident: R4
  doi: 10.1056/NEJMoa051424
– ident: R47
  doi: 10.1038/modpathol.2009.80
– ident: R35
  doi: 10.1200/JCO.2008.18.7229
– ident: R58
  doi: 10.1038/sj.bjc.6690164
– ident: R26
  doi: 10.1158/0008-5472.CAN-10-2907
– ident: R55
  doi: 10.1002/jcp.24260
– ident: R16
  doi: 10.1007/s10555-007-9073-z
– ident: R50
  doi: 10.1007/s11033-009-9873-z
– ident: R45
  doi: 10.1053/j.gastro.2009.06.053
– ident: R1
  doi: 10.1016/j.cell.2011.02.013
– ident: R59
  doi: 10.1002/ijc.23401
– ident: R71
  doi: 10.1007/s12253-012-9556-2
– ident: R40
  doi: 10.1097/CJI.0b013e3181d32f01
– ident: R23
  doi: 10.1038/nri3049
– ident: R12
  doi: 10.1002/ijc.1298
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Snippet Sporadic or hereditary colorectal cancer (CRC) with microsatellite instability (MSI) is frequently characterized by inflammatory lymphocytic infiltration and...
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SubjectTerms Adaptive immunology
Cancer
chemokine
colorectal cancer
cytokine
Human health and pathology
Hépatology and Gastroenterology
Immunology
inflammation
Life Sciences
microsatellite instability
Original Research
Title Characterization of an adaptive immune response in microsatellite-instable colorectal cancer
URI https://www.tandfonline.com/doi/abs/10.4161/onci.29256
https://www.ncbi.nlm.nih.gov/pubmed/25101223
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Volume 3
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